Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)

Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cas...

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Autores: Palomar Cros, Anna, Straif, Kurt, Romaguera, Dora, Aragonés, Nuria, Castaño Vinyals, Gemma, Martín, Vicente, Moreno Aguado, Víctor, Gómez Acebo, Inés, Guevara, Marcela, Aizpurua, Amaia, Molina Barceló, Ana, Jiménez Moleón, José Juan, Tardón, Adonina, Contreras Llanes, Manuel, Marcos Gragera, Rafael, Huerta Castaño, José María, Pérez Gómez, Beatriz, Espinosa, Ana, Hernández Segura, Natalia, Obón Santacana, Mireia, Alonso Molero, Jessica, Burgui, Rosana, Amiano, Pilar, Pinto Carbó, Marina, Olmedo Requena, Rocío, Fernández Tardón, Guillermo, Santos Sánchez, Vanessa, Fernández de Larrea Baz, Nerea, Fernández Villa, Tania, Casabonne, Delphine, Dierssen Sotos, Trinidad, Ardanaz, Eva, Dorronsoro, Ane, Pollán, Marina, Kogevinas, Manolis, Lassale, Camille
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/202622
Acceso en línea:https://hdl.handle.net/2445/202622
Access Level:acceso abierto
Palabra clave:Edulcorants sintètics
Càncer
Nonnutritive sweetener
Cancer
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spelling Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)Palomar Cros, AnnaStraif, KurtRomaguera, DoraAragonés, NuriaCastaño Vinyals, GemmaMartín, VicenteMoreno Aguado, VíctorGómez Acebo, InésGuevara, MarcelaAizpurua, AmaiaMolina Barceló, AnaJiménez Moleón, José JuanTardón, AdoninaContreras Llanes, ManuelMarcos Gragera, RafaelHuerta Castaño, José MaríaPérez Gómez, BeatrizEspinosa, AnaHernández Segura, NataliaObón Santacana, MireiaAlonso Molero, JessicaBurgui, RosanaAmiano, PilarPinto Carbó, MarinaOlmedo Requena, RocíoFernández Tardón, GuillermoSantos Sánchez, VanessaFernández de Larrea Baz, NereaFernández Villa, TaniaCasabonne, DelphineDierssen Sotos, TrinidadArdanaz, EvaDorronsoro, AnePollán, MarinaKogevinas, ManolisLassale, CamilleEdulcorants sintèticsCàncerNonnutritive sweetenerCancerUse of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (<greater than or equal to> third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR=1.58, 95% CI 1.05-2.41, P trend=.03) and stomach cancer (OR=2.27 [0.99-5.44], P trend=.06). High consumption of aspartame, was associated with stomach cancer (OR=2.04 [0.7-5.4], P trend=.05), while a lower risk was observed for breast cancer (OR=0.28 [0.08-0.83], P trend=.03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.Wiley2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/202622Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/ijc.34577International Journal of Cancer, 2023, vol. 153, num. 5, p. 979-993https://doi.org/10.1002/ijc.34577cc by-nc (c) Palomar Cros, Anna et al., 2023http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2026222026-05-29T05:05:01Z
dc.title.none.fl_str_mv Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
title Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
spellingShingle Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
Palomar Cros, Anna
Edulcorants sintètics
Càncer
Nonnutritive sweetener
Cancer
title_short Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
title_full Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
title_fullStr Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
title_full_unstemmed Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
title_sort Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
dc.creator.none.fl_str_mv Palomar Cros, Anna
Straif, Kurt
Romaguera, Dora
Aragonés, Nuria
Castaño Vinyals, Gemma
Martín, Vicente
Moreno Aguado, Víctor
Gómez Acebo, Inés
Guevara, Marcela
Aizpurua, Amaia
Molina Barceló, Ana
Jiménez Moleón, José Juan
Tardón, Adonina
Contreras Llanes, Manuel
Marcos Gragera, Rafael
Huerta Castaño, José María
Pérez Gómez, Beatriz
Espinosa, Ana
Hernández Segura, Natalia
Obón Santacana, Mireia
Alonso Molero, Jessica
Burgui, Rosana
Amiano, Pilar
Pinto Carbó, Marina
Olmedo Requena, Rocío
Fernández Tardón, Guillermo
Santos Sánchez, Vanessa
Fernández de Larrea Baz, Nerea
Fernández Villa, Tania
Casabonne, Delphine
Dierssen Sotos, Trinidad
Ardanaz, Eva
Dorronsoro, Ane
Pollán, Marina
Kogevinas, Manolis
Lassale, Camille
author Palomar Cros, Anna
author_facet Palomar Cros, Anna
Straif, Kurt
Romaguera, Dora
Aragonés, Nuria
Castaño Vinyals, Gemma
Martín, Vicente
Moreno Aguado, Víctor
Gómez Acebo, Inés
Guevara, Marcela
Aizpurua, Amaia
Molina Barceló, Ana
Jiménez Moleón, José Juan
Tardón, Adonina
Contreras Llanes, Manuel
Marcos Gragera, Rafael
Huerta Castaño, José María
Pérez Gómez, Beatriz
Espinosa, Ana
Hernández Segura, Natalia
Obón Santacana, Mireia
Alonso Molero, Jessica
Burgui, Rosana
Amiano, Pilar
Pinto Carbó, Marina
Olmedo Requena, Rocío
Fernández Tardón, Guillermo
Santos Sánchez, Vanessa
Fernández de Larrea Baz, Nerea
Fernández Villa, Tania
Casabonne, Delphine
Dierssen Sotos, Trinidad
Ardanaz, Eva
Dorronsoro, Ane
Pollán, Marina
Kogevinas, Manolis
Lassale, Camille
author_role author
author2 Straif, Kurt
Romaguera, Dora
Aragonés, Nuria
Castaño Vinyals, Gemma
Martín, Vicente
Moreno Aguado, Víctor
Gómez Acebo, Inés
Guevara, Marcela
Aizpurua, Amaia
Molina Barceló, Ana
Jiménez Moleón, José Juan
Tardón, Adonina
Contreras Llanes, Manuel
Marcos Gragera, Rafael
Huerta Castaño, José María
Pérez Gómez, Beatriz
Espinosa, Ana
Hernández Segura, Natalia
Obón Santacana, Mireia
Alonso Molero, Jessica
Burgui, Rosana
Amiano, Pilar
Pinto Carbó, Marina
Olmedo Requena, Rocío
Fernández Tardón, Guillermo
Santos Sánchez, Vanessa
Fernández de Larrea Baz, Nerea
Fernández Villa, Tania
Casabonne, Delphine
Dierssen Sotos, Trinidad
Ardanaz, Eva
Dorronsoro, Ane
Pollán, Marina
Kogevinas, Manolis
Lassale, Camille
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Edulcorants sintètics
Càncer
Nonnutritive sweetener
Cancer
topic Edulcorants sintètics
Càncer
Nonnutritive sweetener
Cancer
description Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (<greater than or equal to> third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR=1.58, 95% CI 1.05-2.41, P trend=.03) and stomach cancer (OR=2.27 [0.99-5.44], P trend=.06). High consumption of aspartame, was associated with stomach cancer (OR=2.04 [0.7-5.4], P trend=.05), while a lower risk was observed for breast cancer (OR=0.28 [0.08-0.83], P trend=.03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/202622
url https://hdl.handle.net/2445/202622
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/ijc.34577
International Journal of Cancer, 2023, vol. 153, num. 5, p. 979-993
https://doi.org/10.1002/ijc.34577
dc.rights.none.fl_str_mv cc by-nc (c) Palomar Cros, Anna et al., 2023
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Palomar Cros, Anna et al., 2023
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404500854308864
score 15,198674

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