A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies

The primary objective of this study was to analyse the current accuracy of targeted and systematic prostate biopsies in detecting csPCa. A secondary objective was to determine whether there are factors predicting the finding of csPCa in targeted biopsies and, if so, to explore the utility of a predi...

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Autores: Morote, J, Picola, N, Muñoz-Rodriguez, J, Paesano, N, Ruiz-Plazas, X, Muñoz-Rivero, MV, Celma, A, Manuel, GGD, Aisian, I, Servian, P, Abascal, JM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p4183
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/4183
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172786109&doi=10.3390%2fcancers15184543&partnerID=40&md5=eed10e27b25c78a7a02e0939915ed28f
Access Level:acceso abierto
Palabra clave:clinically significant prostate cancer detection
systematic biopsy
targeted biopsy
prostate biopsy concordance
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spelling A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic BiopsiesMorote, JPicola, NMuñoz-Rodriguez, JPaesano, NRuiz-Plazas, XMuñoz-Rivero, MVCelma, AManuel, GGDAisian, IServian, PAbascal, JMclinically significant prostate cancer detectionsystematic biopsytargeted biopsyprostate biopsy concordanceThe primary objective of this study was to analyse the current accuracy of targeted and systematic prostate biopsies in detecting csPCa. A secondary objective was to determine whether there are factors predicting the finding of csPCa in targeted biopsies and, if so, to explore the utility of a predictive model for csPCa detection only in targeted biopsies. We analysed 2122 men with suspected PCa, serum PSA > 3 ng/mL, and/or a suspicious digital rectal examination (DRE), who underwent targeted and systematic biopsies between 2021 and 2022. CsPCa (grade group 2 or higher) was detected in 1026 men (48.4%). Discrepancies in csPCa detection in targeted and systematic biopsies were observed in 49.6%, with 13.9% of csPCa cases being detected only in systematic biopsies and 35.7% only in targeted biopsies. A predictive model for csPCa detection only in targeted biopsies was developed from the independent predictors age (years), prostate volume (mL), PI-RADS score (3 to 5), mpMRI Tesla (1.5 vs. 3.0), TRUS-MRI fusion image technique (cognitive vs. software), and prostate biopsy route (transrectal vs. transperineal). The csPCa discrimination ability of targeted biopsies showed an AUC of 0.741 (95% CI 0.721-0.762). The avoidance rate of systematic prostate biopsies went from 0.5% without missing csPCa to 18.3% missing 4.6% of csPCa cases. We conclude that the csPCa diagnostic accuracy of targeted biopsies is higher than that of systematic biopsies. However, a significant rate of csPCa remains detected only in systematic biopsies. A predictive model for the partial omission of systematic biopsies was developed.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/4183https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172786109&doi=10.3390%2fcancers15184543&partnerID=40&md5=eed10e27b25c78a7a02e0939915ed28fCancersISSN: 20726694reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p41832026-06-21T15:30:37Z
dc.title.none.fl_str_mv A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies
title A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies
spellingShingle A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies
Morote, J
clinically significant prostate cancer detection
systematic biopsy
targeted biopsy
prostate biopsy concordance
title_short A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies
title_full A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies
title_fullStr A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies
title_full_unstemmed A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies
title_sort A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies
dc.creator.none.fl_str_mv Morote, J
Picola, N
Muñoz-Rodriguez, J
Paesano, N
Ruiz-Plazas, X
Muñoz-Rivero, MV
Celma, A
Manuel, GGD
Aisian, I
Servian, P
Abascal, JM
author Morote, J
author_facet Morote, J
Picola, N
Muñoz-Rodriguez, J
Paesano, N
Ruiz-Plazas, X
Muñoz-Rivero, MV
Celma, A
Manuel, GGD
Aisian, I
Servian, P
Abascal, JM
author_role author
author2 Picola, N
Muñoz-Rodriguez, J
Paesano, N
Ruiz-Plazas, X
Muñoz-Rivero, MV
Celma, A
Manuel, GGD
Aisian, I
Servian, P
Abascal, JM
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv clinically significant prostate cancer detection
systematic biopsy
targeted biopsy
prostate biopsy concordance
topic clinically significant prostate cancer detection
systematic biopsy
targeted biopsy
prostate biopsy concordance
description The primary objective of this study was to analyse the current accuracy of targeted and systematic prostate biopsies in detecting csPCa. A secondary objective was to determine whether there are factors predicting the finding of csPCa in targeted biopsies and, if so, to explore the utility of a predictive model for csPCa detection only in targeted biopsies. We analysed 2122 men with suspected PCa, serum PSA > 3 ng/mL, and/or a suspicious digital rectal examination (DRE), who underwent targeted and systematic biopsies between 2021 and 2022. CsPCa (grade group 2 or higher) was detected in 1026 men (48.4%). Discrepancies in csPCa detection in targeted and systematic biopsies were observed in 49.6%, with 13.9% of csPCa cases being detected only in systematic biopsies and 35.7% only in targeted biopsies. A predictive model for csPCa detection only in targeted biopsies was developed from the independent predictors age (years), prostate volume (mL), PI-RADS score (3 to 5), mpMRI Tesla (1.5 vs. 3.0), TRUS-MRI fusion image technique (cognitive vs. software), and prostate biopsy route (transrectal vs. transperineal). The csPCa discrimination ability of targeted biopsies showed an AUC of 0.741 (95% CI 0.721-0.762). The avoidance rate of systematic prostate biopsies went from 0.5% without missing csPCa to 18.3% missing 4.6% of csPCa cases. We conclude that the csPCa diagnostic accuracy of targeted biopsies is higher than that of systematic biopsies. However, a significant rate of csPCa remains detected only in systematic biopsies. A predictive model for the partial omission of systematic biopsies was developed.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/4183
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172786109&doi=10.3390%2fcancers15184543&partnerID=40&md5=eed10e27b25c78a7a02e0939915ed28f
url https://i3pt.portalinvestigacion.com/publicaciones/4183
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172786109&doi=10.3390%2fcancers15184543&partnerID=40&md5=eed10e27b25c78a7a02e0939915ed28f
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Cancers
ISSN: 20726694
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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