The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.

Background: Seronegative antiphospholipid syndrome (SN-APS) is often defned as the presence of APS criteria manifestations, negative antiphospholipid antibodies (aPL), and coexistence of APS non-criteria manifestations. Nevertheless, the impact of these non-criteria features is still unclear. On a d...

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Autores: Pires da Rosa, Gilberto, Sousa Pinto, Bernardo, Ferreira, Ester, Araújo, Olga, Barilaro, Giuseppe, Bettencourt, Paulo, Cervera i Segura, Ricard, 1960-, Espinosa Garriga, Gerard
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/186526
Acceso en línea:https://hdl.handle.net/2445/186526
Access Level:acceso abierto
Palabra clave:Malalties autoimmunitàries
Síndrome antifosfolipídica
Autoanticossos
Lupus eritematós
Embaràs
Autoimmune diseases
Antiphospholipid syndrome
Autoantibodies
Lupus erythematosus
Pregnancy
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spelling The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.Pires da Rosa, GilbertoSousa Pinto, BernardoFerreira, EsterAraújo, OlgaBarilaro, GiuseppeBettencourt, PauloCervera i Segura, Ricard, 1960-Espinosa Garriga, GerardMalalties autoimmunitàriesSíndrome antifosfolipídicaAutoanticossosLupus eritematósEmbaràsAutoimmune diseasesAntiphospholipid syndromeAutoantibodiesLupus erythematosusPregnancyBackground: Seronegative antiphospholipid syndrome (SN-APS) is often defned as the presence of APS criteria manifestations, negative antiphospholipid antibodies (aPL), and coexistence of APS non-criteria manifestations. Nevertheless, the impact of these non-criteria features is still unclear. On a diferent note, the relevance of one single aPL positive determination in patients with APS manifestations is another domain with limited evidence. We aim to compare the course of SN-APS and single-positive aPL (SP-aPL) patients with that of individuals with APS manifesta‑ tions without non-criteria features/aPL positivity (controls). Methods: Retrospective analysis of patients with thrombosis/obstetric morbidity assessed in two European hospi‑ tals between 2005 and 2020. Patients were divided into SN-APS, SP-aPL, and control groups. Clinical characteristics, comorbidities, and therapies were compared. Results: A total of 82 patients were included in the SN-APS group, 88 in the SP-aPL group, and 185 in the control group. In Cox regression model, SN-APS displayed more thrombosis recurrence than controls (HR 3.8, 95% CI 2.2-6.5, p<0.001) even when adjusting for the presence of hereditary thrombophilia, systemic lupus erythematosus, or con‑ traceptive hormonal treatment. In SP-aPL, the diference in thrombosis recurrence did not reach statistical signifcance (p=0.078). Indefnite anticoagulation (p<0.001 and p=0.008, respectively) and vitamin K antagonist (VKA) use (p<0.001 in both cases) were more common in SN-APS/SP-aPL. Conclusion: SN-APS displayed more thrombosis recurrence, indefnite anticoagulation, and VKA use than controls without non-criteria manifestations. The presence of such features in patients with thrombosis and negative aPL may negatively impact their clinical course. Keywords: Antiphospholipid syndrome, Antiphospholipid antibodies, Seronegative, Single positive, Non-criteria manifestationsBioMed Central2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/186526Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s13075-021-02702-9Arthritis Research & Therapy, 2022, vol. 24, num. 1, p. 9https://doi.org/10.1186/s13075-021-02702-9cc-by (c) Pires da Rosa, Gilberto et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1865262026-05-29T05:05:01Z
dc.title.none.fl_str_mv The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.
title The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.
spellingShingle The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.
Pires da Rosa, Gilberto
Malalties autoimmunitàries
Síndrome antifosfolipídica
Autoanticossos
Lupus eritematós
Embaràs
Autoimmune diseases
Antiphospholipid syndrome
Autoantibodies
Lupus erythematosus
Pregnancy
title_short The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.
title_full The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.
title_fullStr The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.
title_full_unstemmed The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.
title_sort The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study.
dc.creator.none.fl_str_mv Pires da Rosa, Gilberto
Sousa Pinto, Bernardo
Ferreira, Ester
Araújo, Olga
Barilaro, Giuseppe
Bettencourt, Paulo
Cervera i Segura, Ricard, 1960-
Espinosa Garriga, Gerard
author Pires da Rosa, Gilberto
author_facet Pires da Rosa, Gilberto
Sousa Pinto, Bernardo
Ferreira, Ester
Araújo, Olga
Barilaro, Giuseppe
Bettencourt, Paulo
Cervera i Segura, Ricard, 1960-
Espinosa Garriga, Gerard
author_role author
author2 Sousa Pinto, Bernardo
Ferreira, Ester
Araújo, Olga
Barilaro, Giuseppe
Bettencourt, Paulo
Cervera i Segura, Ricard, 1960-
Espinosa Garriga, Gerard
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties autoimmunitàries
Síndrome antifosfolipídica
Autoanticossos
Lupus eritematós
Embaràs
Autoimmune diseases
Antiphospholipid syndrome
Autoantibodies
Lupus erythematosus
Pregnancy
topic Malalties autoimmunitàries
Síndrome antifosfolipídica
Autoanticossos
Lupus eritematós
Embaràs
Autoimmune diseases
Antiphospholipid syndrome
Autoantibodies
Lupus erythematosus
Pregnancy
description Background: Seronegative antiphospholipid syndrome (SN-APS) is often defned as the presence of APS criteria manifestations, negative antiphospholipid antibodies (aPL), and coexistence of APS non-criteria manifestations. Nevertheless, the impact of these non-criteria features is still unclear. On a diferent note, the relevance of one single aPL positive determination in patients with APS manifestations is another domain with limited evidence. We aim to compare the course of SN-APS and single-positive aPL (SP-aPL) patients with that of individuals with APS manifesta‑ tions without non-criteria features/aPL positivity (controls). Methods: Retrospective analysis of patients with thrombosis/obstetric morbidity assessed in two European hospi‑ tals between 2005 and 2020. Patients were divided into SN-APS, SP-aPL, and control groups. Clinical characteristics, comorbidities, and therapies were compared. Results: A total of 82 patients were included in the SN-APS group, 88 in the SP-aPL group, and 185 in the control group. In Cox regression model, SN-APS displayed more thrombosis recurrence than controls (HR 3.8, 95% CI 2.2-6.5, p<0.001) even when adjusting for the presence of hereditary thrombophilia, systemic lupus erythematosus, or con‑ traceptive hormonal treatment. In SP-aPL, the diference in thrombosis recurrence did not reach statistical signifcance (p=0.078). Indefnite anticoagulation (p<0.001 and p=0.008, respectively) and vitamin K antagonist (VKA) use (p<0.001 in both cases) were more common in SN-APS/SP-aPL. Conclusion: SN-APS displayed more thrombosis recurrence, indefnite anticoagulation, and VKA use than controls without non-criteria manifestations. The presence of such features in patients with thrombosis and negative aPL may negatively impact their clinical course. Keywords: Antiphospholipid syndrome, Antiphospholipid antibodies, Seronegative, Single positive, Non-criteria manifestations
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/186526
url https://hdl.handle.net/2445/186526
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s13075-021-02702-9
Arthritis Research & Therapy, 2022, vol. 24, num. 1, p. 9
https://doi.org/10.1186/s13075-021-02702-9
dc.rights.none.fl_str_mv cc-by (c) Pires da Rosa, Gilberto et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Pires da Rosa, Gilberto et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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