Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis

Introduction: This study aimed to investigate the effcacy and safety of quantum molecular resonance (QMR) electrotherapy in patients with dry eye disease (DED). Methods: A systematic review with metaanalysis, reporting the effects of QMR electro therapy in three databases, PubMed, Scopus and Web of...

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Authors: Ballesteros Sánchez, Antonio, Rocha de Lossada, Carlos, Sánchez González, José María, Tedesco, Giovanni Roberto, Borroni, Davide
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/176142
Online Access:https://hdl.handle.net/11441/176142
https://doi.org/10.1007/s40123-025-01133-y
Access Level:Open access
Keyword:Rexon-Eye
Quantum molecular resonance electrotherapy
Transcutaneous electrical stimulation
Dry eye disease
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spelling Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysisBallesteros Sánchez, AntonioRocha de Lossada, CarlosSánchez González, José MaríaTedesco, Giovanni RobertoBorroni, DavideRexon-EyeQuantum molecular resonance electrotherapyTranscutaneous electrical stimulationDry eye diseaseIntroduction: This study aimed to investigate the effcacy and safety of quantum molecular resonance (QMR) electrotherapy in patients with dry eye disease (DED). Methods: A systematic review with metaanalysis, reporting the effects of QMR electro therapy in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement with a search period ending on December 24, 2024. Results: Seven studies, including four open-label, non-comparative trials and three randomized controlled studies (RCTs), were included. Although all studies reported signif cant improvements in most outcome measures after QMR electrotherapy, the meta-analysis indicated that overall effcacy did not signif cantly favor either group when comparing QMR electrotherapy to controls (SMD 0.40; 95% CI − 0.06 to 0.86; P = 0.09; I 2 = 85%). However, only the change in DED symptoms was signif cantly favorable for QMR electrotherapy com pared to controls (SMD 0.69; 95% CI 0.30–1.08; P = 0.0005; I 2 = 28%). In sensitivity analyses, overall effcacy remained non-signifcant when comparing QMR electrotherapy to placebo QMR electrotherapy (SMD 0.14; 95% CI − 0.24 to 0.52; P=0.46; I 2 =65%). Additionally, changes in DED symptoms, TBUT, ST, and CFS also showed no statistically signifcant differences between both groups. Regarding safety, most studies reported no AEs, with a satisfactory tolerability profle for QMR electrotherapy. However, a meta-analysis could not be performed. Conclusions: With the current scientifc litera ture available to date, QMR electrotherapy seems to show some evidence of alleviating DED symp toms. However, evidence supporting its effcacy in improving DED signs and safety remains lim ited. Therefore, further RCTs with robust designs are needed to confrm these fndings.SpringerFísica de la Materia CondensadaCirugía2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/176142https://doi.org/10.1007/s40123-025-01133-yreponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésOphthalmology and Therapy, 14 (5), 101733.https://doi.org/10.1007/s40123-025-01133-yinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1761422026-06-17T12:51:07Z
dc.title.none.fl_str_mv Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis
title Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis
spellingShingle Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis
Ballesteros Sánchez, Antonio
Rexon-Eye
Quantum molecular resonance electrotherapy
Transcutaneous electrical stimulation
Dry eye disease
title_short Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis
title_full Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis
title_fullStr Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis
title_full_unstemmed Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis
title_sort Efficacy and Safety of Quantum Molecular Resonance Electrotherapy in Dry Eye Disease: A Systematic Review with Meta-analysis
dc.creator.none.fl_str_mv Ballesteros Sánchez, Antonio
Rocha de Lossada, Carlos
Sánchez González, José María
Tedesco, Giovanni Roberto
Borroni, Davide
author Ballesteros Sánchez, Antonio
author_facet Ballesteros Sánchez, Antonio
Rocha de Lossada, Carlos
Sánchez González, José María
Tedesco, Giovanni Roberto
Borroni, Davide
author_role author
author2 Rocha de Lossada, Carlos
Sánchez González, José María
Tedesco, Giovanni Roberto
Borroni, Davide
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Física de la Materia Condensada
Cirugía
dc.subject.none.fl_str_mv Rexon-Eye
Quantum molecular resonance electrotherapy
Transcutaneous electrical stimulation
Dry eye disease
topic Rexon-Eye
Quantum molecular resonance electrotherapy
Transcutaneous electrical stimulation
Dry eye disease
description Introduction: This study aimed to investigate the effcacy and safety of quantum molecular resonance (QMR) electrotherapy in patients with dry eye disease (DED). Methods: A systematic review with metaanalysis, reporting the effects of QMR electro therapy in three databases, PubMed, Scopus and Web of Science, was performed according to the PRISMA statement with a search period ending on December 24, 2024. Results: Seven studies, including four open-label, non-comparative trials and three randomized controlled studies (RCTs), were included. Although all studies reported signif cant improvements in most outcome measures after QMR electrotherapy, the meta-analysis indicated that overall effcacy did not signif cantly favor either group when comparing QMR electrotherapy to controls (SMD 0.40; 95% CI − 0.06 to 0.86; P = 0.09; I 2 = 85%). However, only the change in DED symptoms was signif cantly favorable for QMR electrotherapy com pared to controls (SMD 0.69; 95% CI 0.30–1.08; P = 0.0005; I 2 = 28%). In sensitivity analyses, overall effcacy remained non-signifcant when comparing QMR electrotherapy to placebo QMR electrotherapy (SMD 0.14; 95% CI − 0.24 to 0.52; P=0.46; I 2 =65%). Additionally, changes in DED symptoms, TBUT, ST, and CFS also showed no statistically signifcant differences between both groups. Regarding safety, most studies reported no AEs, with a satisfactory tolerability profle for QMR electrotherapy. However, a meta-analysis could not be performed. Conclusions: With the current scientifc litera ture available to date, QMR electrotherapy seems to show some evidence of alleviating DED symp toms. However, evidence supporting its effcacy in improving DED signs and safety remains lim ited. Therefore, further RCTs with robust designs are needed to confrm these fndings.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/176142
https://doi.org/10.1007/s40123-025-01133-y
url https://hdl.handle.net/11441/176142
https://doi.org/10.1007/s40123-025-01133-y
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Ophthalmology and Therapy, 14 (5), 101733.
https://doi.org/10.1007/s40123-025-01133-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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