Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial

Acute hypoxemic respiratory failure; COVID-19; Intubation

Detalles Bibliográficos
Autores: Ibarra-Estrada, Miguel, Li, Jie, Pavlov, Ivan, Perez, Yonatan, Roca Gas, Oriol, Tavernier, Elsa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/8000
Acceso en línea:https://hdl.handle.net/11351/8000
Access Level:acceso abierto
Palabra clave:Insuficiència respiratòria - Tractament
COVID-19 (Malaltia) - Complicacions
DISEASES::Respiratory Tract Diseases::Respiration Disorders::Respiratory Insufficiency
Other subheadings::Other subheadings::/therapy
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::enfermedades respiratorias::trastornos respiratorios::insuficiencia respiratoria
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
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dc.title.none.fl_str_mv Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial
title Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial
spellingShingle Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial
Ibarra-Estrada, Miguel
Insuficiència respiratòria - Tractament
COVID-19 (Malaltia) - Complicacions
DISEASES::Respiratory Tract Diseases::Respiration Disorders::Respiratory Insufficiency
Other subheadings::Other subheadings::/therapy
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::enfermedades respiratorias::trastornos respiratorios::insuficiencia respiratoria
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
title_short Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial
title_full Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial
title_fullStr Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial
title_full_unstemmed Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial
title_sort Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial
dc.creator.none.fl_str_mv Ibarra-Estrada, Miguel
Li, Jie
Pavlov, Ivan
Perez, Yonatan
Roca Gas, Oriol
Tavernier, Elsa
author Ibarra-Estrada, Miguel
author_facet Ibarra-Estrada, Miguel
Li, Jie
Pavlov, Ivan
Perez, Yonatan
Roca Gas, Oriol
Tavernier, Elsa
author_role author
author2 Li, Jie
Pavlov, Ivan
Perez, Yonatan
Roca Gas, Oriol
Tavernier, Elsa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Ibarra-Estrada M] Unidad de Terapia Intensiva, Hospital Civil Fray Antonio Alcalde, Jalisco, Mexico. [Li J] Department of Cardio pulmonary Sciences, Division of Respiratory Care, Rush University, Chicago, IL, USA. [Pavlov I] Department of Emergency Medicine, Hôpital de Verdun, Montréal, Québec, Canada. [Perez Y] CHRU Tours, Médecine Intensive Réanimation, CIC INSERM 1415, CRICS-TriggerSep FCRIN Research Network, Tours, France. [Roca O] Unitat de Cures Intensives, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Ciber Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. [Tavernier E] Clinical Investigation Center, INSERM 1415, CHRU Tours, Tours, France. Methods in Patients Centered Outcomes and Health Research, INSERM, UMR 1246, Nantes, France
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Insuficiència respiratòria - Tractament
COVID-19 (Malaltia) - Complicacions
DISEASES::Respiratory Tract Diseases::Respiration Disorders::Respiratory Insufficiency
Other subheadings::Other subheadings::/therapy
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::enfermedades respiratorias::trastornos respiratorios::insuficiencia respiratoria
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
topic Insuficiència respiratòria - Tractament
COVID-19 (Malaltia) - Complicacions
DISEASES::Respiratory Tract Diseases::Respiration Disorders::Respiratory Insufficiency
Other subheadings::Other subheadings::/therapy
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::/complications
ENFERMEDADES::enfermedades respiratorias::trastornos respiratorios::insuficiencia respiratoria
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::/complicaciones
description Acute hypoxemic respiratory failure; COVID-19; Intubation
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8000
url https://hdl.handle.net/11351/8000
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Critical Care;26
https://doi.org/10.1186/s13054-022-03950-0
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404489075654656
spelling Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trialIbarra-Estrada, MiguelLi, JiePavlov, IvanPerez, YonatanRoca Gas, OriolTavernier, ElsaInsuficiència respiratòria - TractamentCOVID-19 (Malaltia) - ComplicacionsDISEASES::Respiratory Tract Diseases::Respiration Disorders::Respiratory InsufficiencyOther subheadings::Other subheadings::/therapyDISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus InfectionsOther subheadings::Other subheadings::Other subheadings::/complicationsENFERMEDADES::enfermedades respiratorias::trastornos respiratorios::insuficiencia respiratoriaOtros calificadores::Otros calificadores::/terapiaENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por CoronavirusOtros calificadores::Otros calificadores::Otros calificadores::/complicacionesAcute hypoxemic respiratory failure; COVID-19; IntubationInsuficiencia respiratoria hipoxémica aguda; COVID-19; IntubaciónInsuficiència respiratòria hipoxèmica aguda; COVID-19; IntubacióBackground Awake prone positioning (APP) improves oxygenation in coronavirus disease (COVID-19) patients and, when successful, may decrease the risk of intubation. However, factors associated with APP success remain unknown. In this secondary analysis, we aimed to assess whether APP can reduce intubation rate in patients with COVID-19 and to focus on the factors associated with success. Methods In this multicenter randomized controlled trial, conducted in three high-acuity units, we randomly assigned patients with COVID-19-induced acute hypoxemic respiratory failure (AHRF) requiring high-flow nasal cannula (HFNC) oxygen to APP or standard care. Primary outcome was intubation rate at 28 days. Multivariate analyses were performed to identify the predictors associated to treatment success (survival without intubation). Results Among 430 patients randomized, 216 were assigned to APP and 214 to standard care. The APP group had a lower intubation rate (30% vs 43%, relative risk [RR] 0.70; CI95 0.54–0.90, P = 0.006) and shorter hospital length of stay (11 interquartile range [IQR, 9–14] vs 13 [IQR, 10–17] days, P = 0.001). A respiratory rate ≤ 25 bpm at enrollment, an increase in ROX index > 1.25 after first APP session, APP duration > 8 h/day, and a decrease in lung ultrasound score ≥ 2 within the first 3 days were significantly associated with treatment success for APP. Conclusion In patients with COVID-19-induced AHRF treated by HFNC, APP reduced intubation rate and improved treatment success. A longer APP duration is associated with APP success, while the increase in ROX index and decrease in lung ultrasound score after APP can also help identify patients most likely to benefit.BMCInstitut Català de la Salut[Ibarra-Estrada M] Unidad de Terapia Intensiva, Hospital Civil Fray Antonio Alcalde, Jalisco, Mexico. [Li J] Department of Cardio pulmonary Sciences, Division of Respiratory Care, Rush University, Chicago, IL, USA. [Pavlov I] Department of Emergency Medicine, Hôpital de Verdun, Montréal, Québec, Canada. [Perez Y] CHRU Tours, Médecine Intensive Réanimation, CIC INSERM 1415, CRICS-TriggerSep FCRIN Research Network, Tours, France. [Roca O] Unitat de Cures Intensives, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Ciber Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. [Tavernier E] Clinical Investigation Center, INSERM 1415, CHRU Tours, Tours, France. Methods in Patients Centered Outcomes and Health Research, INSERM, UMR 1246, Nantes, FranceVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8000Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésCritical Care;26https://doi.org/10.1186/s13054-022-03950-0Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/80002026-06-12T09:38:37Z
score 15,812455

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