Gemin 5: a multitasking RNA-binding protein involved in translational control

17 páginas; contiene gráficos y tablas

Detalles Bibliográficos
Autores: Piñeiro, David, Fernández-Chamorro, Javier, Francisco-Velilla, Rosario, Martínez-Salas, Encarnación
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/123197
Acceso en línea:http://hdl.handle.net/10261/123197
Access Level:acceso abierto
Palabra clave:Gemin5
RNA-binding proteins
Translation control
IRES elements
snRNPs
Picornavirus infection
Gemin5 proteolysis
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spelling Gemin 5: a multitasking RNA-binding protein involved in translational controlPiñeiro, DavidFernández-Chamorro, JavierFrancisco-Velilla, RosarioMartínez-Salas, EncarnaciónGemin5RNA-binding proteinsTranslation controlIRES elementssnRNPsPicornavirus infectionGemin5 proteolysis17 páginas; contiene gráficos y tablasGemin5 is a RNA-binding protein (RBP) that was first identified as a peripheral component of the survival of motor neurons (SMN) complex. This predominantly cytoplasmic protein recognises the small nuclear RNAs (snRNAs) through its WD repeat domains, allowing assembly of the SMN complex into small nuclear ribonucleoproteins (snRNPs). Additionally, the amino-terminal end of the protein has been reported to possess cap-binding capacity and to interact with the eukaryotic initiation factor 4E (eIF4E). Gemin5 was also shown to downregulate translation, to be a substrate of the picornavirus L protease and to interact with viral internal ribosome entry site (IRES) elements via a bipartite non-canonical RNA-binding site located at its carboxy-terminal end. These features link Gemin5 with translation control events. Thus, beyond its role in snRNPs biogenesis, Gemin5 appears to be a multitasking protein cooperating in various RNA-guided processes. In this review, we will summarise current knowledge of Gemin5 functions. We will discuss the involvement of the protein on translation control and propose a model to explain how the proteolysis fragments of this RBP in picornavirus-infected cells could modulate protein synthesis.David Piñeiro is supported by Biotechnology and Biological Sciences Research Council (BBSRC) Grant BB/M006700/1. Work at Encarna Martinez-Salas’s laboratory was supported by Grants CSD2009-00080, BFU2011-25437 from Ministerio de Economía y Competitividad (MINECO) and by an institutional grant from Fundación Ramón ArecesWe acknowledge support of the publication fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICI)Peer reviewedMultidisciplinary Digital Publishing InstituteBiotechnology and Biological Sciences Research Council (UK)Ministerio de Economía y Competitividad (España)Fundación Ramón ArecesConsejo Superior de Investigaciones Científicas (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/123197reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/biom5020528Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1231972026-05-22T06:33:51Z
dc.title.none.fl_str_mv Gemin 5: a multitasking RNA-binding protein involved in translational control
title Gemin 5: a multitasking RNA-binding protein involved in translational control
spellingShingle Gemin 5: a multitasking RNA-binding protein involved in translational control
Piñeiro, David
Gemin5
RNA-binding proteins
Translation control
IRES elements
snRNPs
Picornavirus infection
Gemin5 proteolysis
title_short Gemin 5: a multitasking RNA-binding protein involved in translational control
title_full Gemin 5: a multitasking RNA-binding protein involved in translational control
title_fullStr Gemin 5: a multitasking RNA-binding protein involved in translational control
title_full_unstemmed Gemin 5: a multitasking RNA-binding protein involved in translational control
title_sort Gemin 5: a multitasking RNA-binding protein involved in translational control
dc.creator.none.fl_str_mv Piñeiro, David
Fernández-Chamorro, Javier
Francisco-Velilla, Rosario
Martínez-Salas, Encarnación
author Piñeiro, David
author_facet Piñeiro, David
Fernández-Chamorro, Javier
Francisco-Velilla, Rosario
Martínez-Salas, Encarnación
author_role author
author2 Fernández-Chamorro, Javier
Francisco-Velilla, Rosario
Martínez-Salas, Encarnación
author2_role author
author
author
dc.contributor.none.fl_str_mv Biotechnology and Biological Sciences Research Council (UK)
Ministerio de Economía y Competitividad (España)
Fundación Ramón Areces
Consejo Superior de Investigaciones Científicas (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Gemin5
RNA-binding proteins
Translation control
IRES elements
snRNPs
Picornavirus infection
Gemin5 proteolysis
topic Gemin5
RNA-binding proteins
Translation control
IRES elements
snRNPs
Picornavirus infection
Gemin5 proteolysis
description 17 páginas; contiene gráficos y tablas
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/123197
url http://hdl.handle.net/10261/123197
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3390/biom5020528
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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