New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy

[EN] Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in s...

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Autores: Hernández Teruel, Adrián, Gonzalez-Alvarez, Isabel, Bermejo, Marival, Merino Sanjuán, Virginia, Gonzalez-Alvarez, Marta, Marcos Martínez, María Dolores|||0000-0001-7079-8589, Sancenón Galarza, Félix|||0000-0002-5205-7135, Martínez-Máñez, Ramón|||0000-0001-5873-9674
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/169426
Acceso en línea:https://riunet.upv.es/handle/10251/169426
Access Level:acceso abierto
Palabra clave:Intestinal permeability
Colon
Drug delivery
Inflammatory bowel diseases
QUIMICA INORGANICA
QUIMICA ORGANICA
QUIMICA ANALITICA
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network_name_str España
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spelling New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease TherapyHernández Teruel, AdriánGonzalez-Alvarez, IsabelBermejo, MarivalMerino Sanjuán, VirginiaGonzalez-Alvarez, MartaMarcos Martínez, María Dolores|||0000-0001-7079-8589Sancenón Galarza, Félix|||0000-0002-5205-7135Martínez-Máñez, Ramón|||0000-0001-5873-9674Intestinal permeabilityColonDrug deliveryInflammatory bowel diseasesQUIMICA INORGANICAQUIMICA ORGANICAQUIMICA ANALITICA[EN] Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in small intestine. This review focused on the reported contributions in the last four years to improve the effectiveness of treatments of inflammatory bowel diseases. The work concludes that there has been an increase in the development of CDDS in which pH, specific enzymes, reactive oxygen species (ROS), or a combination of all of these triggers the release. These delivery systems demonstrated a therapeutic improvement with fewer adverse effects. Future perspectives to the treatment of this disease include the elucidation of molecular basis of IBD diseases in order to design more specific treatments, and the performance of more in vivo assays to validate the specificity and stability of the obtained systems.The authors want to thank the Spanish Government (project RTI2018-100910-B-C41 (MCUI/AEI/FEDER, UE)) and the Generalitat Valenciana (project PROMETEO/2018/024) for support. This work was also supported by the project "MODELOS IN VITRO DE EVALUACION BIOFARMACEUTICA" SAF2016-78756(AEI/FEDER, EU) funded by Agencia Estatal Investigacion and European Union, through FEDER (Fondo Europeo de Desarrollo Regional).MDPI AGEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialDepartamento de QuímicaEscuela Técnica Superior de Ingeniería IndustrialInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo TecnológicoGeneralitat ValencianaAgencia Estatal de InvestigaciónEuropean Regional Development FundMinisterio de Economía, Industria y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20202020-09-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/169426reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 SAF2016-78756-P MODELOS IN VITRO DE EVALUACION BIOFARMACEUTICA: BARRERAS BIOLOGICAS Y DISOLUCION BIOPREDICTIVAGeneralitat Valenciana https://doi.org/10.13039/501100003359 PROMETEO%2F2018%2F024 Sistemas avanzados de liberación controladaAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-100910-B-C41 MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALAopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1694262026-06-13T07:49:27Z
dc.title.none.fl_str_mv New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy
title New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy
spellingShingle New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy
Hernández Teruel, Adrián
Intestinal permeability
Colon
Drug delivery
Inflammatory bowel diseases
QUIMICA INORGANICA
QUIMICA ORGANICA
QUIMICA ANALITICA
title_short New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy
title_full New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy
title_fullStr New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy
title_full_unstemmed New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy
title_sort New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy
dc.creator.none.fl_str_mv Hernández Teruel, Adrián
Gonzalez-Alvarez, Isabel
Bermejo, Marival
Merino Sanjuán, Virginia
Gonzalez-Alvarez, Marta
Marcos Martínez, María Dolores|||0000-0001-7079-8589
Sancenón Galarza, Félix|||0000-0002-5205-7135
Martínez-Máñez, Ramón|||0000-0001-5873-9674
author Hernández Teruel, Adrián
author_facet Hernández Teruel, Adrián
Gonzalez-Alvarez, Isabel
Bermejo, Marival
Merino Sanjuán, Virginia
Gonzalez-Alvarez, Marta
Marcos Martínez, María Dolores|||0000-0001-7079-8589
Sancenón Galarza, Félix|||0000-0002-5205-7135
Martínez-Máñez, Ramón|||0000-0001-5873-9674
author_role author
author2 Gonzalez-Alvarez, Isabel
Bermejo, Marival
Merino Sanjuán, Virginia
Gonzalez-Alvarez, Marta
Marcos Martínez, María Dolores|||0000-0001-7079-8589
Sancenón Galarza, Félix|||0000-0002-5205-7135
Martínez-Máñez, Ramón|||0000-0001-5873-9674
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Departamento de Química
Escuela Técnica Superior de Ingeniería Industrial
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico
Generalitat Valenciana
Agencia Estatal de Investigación
European Regional Development Fund
Ministerio de Economía, Industria y Competitividad
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Intestinal permeability
Colon
Drug delivery
Inflammatory bowel diseases
QUIMICA INORGANICA
QUIMICA ORGANICA
QUIMICA ANALITICA
topic Intestinal permeability
Colon
Drug delivery
Inflammatory bowel diseases
QUIMICA INORGANICA
QUIMICA ORGANICA
QUIMICA ANALITICA
description [EN] Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in small intestine. This review focused on the reported contributions in the last four years to improve the effectiveness of treatments of inflammatory bowel diseases. The work concludes that there has been an increase in the development of CDDS in which pH, specific enzymes, reactive oxygen species (ROS), or a combination of all of these triggers the release. These delivery systems demonstrated a therapeutic improvement with fewer adverse effects. Future perspectives to the treatment of this disease include the elucidation of molecular basis of IBD diseases in order to design more specific treatments, and the performance of more in vivo assays to validate the specificity and stability of the obtained systems.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-09-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/169426
url https://riunet.upv.es/handle/10251/169426
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 SAF2016-78756-P MODELOS IN VITRO DE EVALUACION BIOFARMACEUTICA: BARRERAS BIOLOGICAS Y DISOLUCION BIOPREDICTIVA
Generalitat Valenciana https://doi.org/10.13039/501100003359 PROMETEO%2F2018%2F024 Sistemas avanzados de liberación controlada
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-100910-B-C41 MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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