Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer

© 2021 Saiz-Ladera, Baliu-Piqué, Cimas, Manzano, García-Barberán, Camarero, Hinojal, Pandiella, Győrffy, Stewart, Cruz-Hernández, Pérez-Segura and Ocana.

Detalhes bibliográficos
Autores: Saiz-Ladera, Cristina, Baliu-Piqué, Mariona, Cimas, Francisco J., Manzano, Aranzazu, García-Barberán, Vanesa, Cabezas Camarero, Santiago, Fernández-Hinojal, Gonzalo, Pandiella, Atanasio, Győrffy, Balázs, Stewart, David, Cruz, Juan Jesús, Pérez-Segura, Pedro, Ocaña, Alberto
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/262379
Acesso em linha:http://hdl.handle.net/10261/262379
Access Level:acceso abierto
Palavra-chave:Head and neck squamous cell carcinoma (HNSCC)
Human papillomavirus
Transcriptome signature
Immune gene signatures
Cervical squamous cell carcinoma (CSCC)
id ES_20e2c2ac7fcd24209a65985e277740ea
oai_identifier_str oai:digital.csic.es:10261/262379
network_acronym_str ES
network_name_str España
repository_id_str
spelling Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical CancerSaiz-Ladera, CristinaBaliu-Piqué, MarionaCimas, Francisco J.Manzano, AranzazuGarcía-Barberán, VanesaCabezas Camarero, SantiagoFernández-Hinojal, GonzaloPandiella, AtanasioGyőrffy, BalázsStewart, DavidCruz, Juan JesúsPérez-Segura, PedroOcaña, AlbertoHead and neck squamous cell carcinoma (HNSCC)Human papillomavirusTranscriptome signatureImmune gene signaturesCervical squamous cell carcinoma (CSCC)© 2021 Saiz-Ladera, Baliu-Piqué, Cimas, Manzano, García-Barberán, Camarero, Hinojal, Pandiella, Győrffy, Stewart, Cruz-Hernández, Pérez-Segura and Ocana.Targeting the immune system has emerged as an effective therapeutic strategy for the treatment of various tumor types, including Head and Neck Squamous Cell Carcinoma (HNSCC) and Non-small-Cell Lung Cancer (NSCLC), and checkpoint inhibitors have shown to improve patient survival in these tumor types. Unfortunately, not all cancers respond to these agents, making it necessary to identify responsive tumors. Several biomarkers of response have been described and clinically tested. As of yet what seems to be clear is that a pre-activation state of the immune system is necessary for these agents to be efficient. In this study, using established transcriptomic signatures, we identified a group of gene combination associated with favorable outcome in HNSCC linked to a higher presence of immune effector cells. CD2, CD3D, CD3E, and CXCR6 combined gene expression is associated with improved outcome of HNSCC patients and an increase of infiltrating immune effector cells. This new signature also identifies a subset of cervical squamous cell carcinoma (CSCC) patients with favorable prognosis, who show an increased presence of immune effector cells in the tumor, which outcome shows similarities with the HP-positive HNSCC cohort of patients. In addition, CD2, CD3D, CD3E, and CXCR6 signature is able to predict the best favorable prognosis in terms of overall survival of CSSC patients. Of note, these findings were not reproduced in other squamous cell carcinomas like esophageal SCC or lung SCC. Prospective confirmatory studies should be employed to validate these findings.This work has been supported by Instituto de Salud Carlos III (PI16/01121 and PI19/00808), ACEPAIN; Diputación de Albacete, CIBERONC and CRIS Cancer Foundation (to AO). Ministry of Economy and Competitiveness of Spain (BFU2015-71371-R), the Instituto de Salud Carlos III through the Spanish Cancer Centers Network Program (RD12/0036/0003) and CIBERONC, the scientific foundation of the AECC and the CRIS Foundation (to AP). The work carried out in our laboratories receive support from the European Community through the regional development funding program (FEDER).Frontiers MediaInstituto de Salud Carlos IIIAcepain AlbaceteDiputación de AlbaceteFundación CRIS contra el CáncerMinisterio de Economía y Competitividad (España)Asociación Española Contra el CáncerEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/262379reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//BFU2015-71371-Rhttp://dx.doi.org/10.3389/fonc.2021.714550Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2623792026-05-22T06:33:51Z
dc.title.none.fl_str_mv Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer
title Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer
spellingShingle Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer
Saiz-Ladera, Cristina
Head and neck squamous cell carcinoma (HNSCC)
Human papillomavirus
Transcriptome signature
Immune gene signatures
Cervical squamous cell carcinoma (CSCC)
title_short Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer
title_full Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer
title_fullStr Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer
title_full_unstemmed Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer
title_sort Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer
dc.creator.none.fl_str_mv Saiz-Ladera, Cristina
Baliu-Piqué, Mariona
Cimas, Francisco J.
Manzano, Aranzazu
García-Barberán, Vanesa
Cabezas Camarero, Santiago
Fernández-Hinojal, Gonzalo
Pandiella, Atanasio
Győrffy, Balázs
Stewart, David
Cruz, Juan Jesús
Pérez-Segura, Pedro
Ocaña, Alberto
author Saiz-Ladera, Cristina
author_facet Saiz-Ladera, Cristina
Baliu-Piqué, Mariona
Cimas, Francisco J.
Manzano, Aranzazu
García-Barberán, Vanesa
Cabezas Camarero, Santiago
Fernández-Hinojal, Gonzalo
Pandiella, Atanasio
Győrffy, Balázs
Stewart, David
Cruz, Juan Jesús
Pérez-Segura, Pedro
Ocaña, Alberto
author_role author
author2 Baliu-Piqué, Mariona
Cimas, Francisco J.
Manzano, Aranzazu
García-Barberán, Vanesa
Cabezas Camarero, Santiago
Fernández-Hinojal, Gonzalo
Pandiella, Atanasio
Győrffy, Balázs
Stewart, David
Cruz, Juan Jesús
Pérez-Segura, Pedro
Ocaña, Alberto
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Acepain Albacete
Diputación de Albacete
Fundación CRIS contra el Cáncer
Ministerio de Economía y Competitividad (España)
Asociación Española Contra el Cáncer
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Head and neck squamous cell carcinoma (HNSCC)
Human papillomavirus
Transcriptome signature
Immune gene signatures
Cervical squamous cell carcinoma (CSCC)
topic Head and neck squamous cell carcinoma (HNSCC)
Human papillomavirus
Transcriptome signature
Immune gene signatures
Cervical squamous cell carcinoma (CSCC)
description © 2021 Saiz-Ladera, Baliu-Piqué, Cimas, Manzano, García-Barberán, Camarero, Hinojal, Pandiella, Győrffy, Stewart, Cruz-Hernández, Pérez-Segura and Ocana.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/262379
url http://hdl.handle.net/10261/262379
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//BFU2015-71371-R
http://dx.doi.org/10.3389/fonc.2021.714550
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404484703092737
score 15,811543

Registos relacionados