Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fraction

The prognostic value of biomarkers in patients with heart failure (HF) and mid-range (HFmrEF) or preserved ejection fraction (HFpEF) has not been widely addressed. The aim of this study was to assess whether the prognostic value of growth differentiation factor 15 (GDF-15) is superior to that of N-t...

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Authors: Mendez Fernandez, Ana Belen, Ferrero-Gregori, Andreu|||0000-0001-6492-2416, García Osuna, Álvaro|||0000-0002-6682-0226, Mirabet Pérez, Sonia|||0000-0001-5955-2748, Pirla, Maria José, Cinca, Juan|||0000-0003-4819-4265, Ordóñez, J. (Jordi)|||0000-0003-4896-5832, Roig, Eulàlia|||0000-0002-3421-4985
Format: article
Publication Date:2020
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:238784
Online Access:https://ddd.uab.cat/record/238784
https://dx.doi.org/urn:doi:10.1002/ehf2.12621
Access Level:Open access
Keyword:GDF-15
HFmrEF
HFpEF
Chronic heart failure
Biomarkers
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spelling Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fractionMendez Fernandez, Ana BelenFerrero-Gregori, Andreu|||0000-0001-6492-2416García Osuna, Álvaro|||0000-0002-6682-0226Mirabet Pérez, Sonia|||0000-0001-5955-2748Pirla, Maria JoséCinca, Juan|||0000-0003-4819-4265Ordóñez, J. (Jordi)|||0000-0003-4896-5832Roig, Eulàlia|||0000-0002-3421-4985GDF-15HFmrEFHFpEFChronic heart failureBiomarkersThe prognostic value of biomarkers in patients with heart failure (HF) and mid-range (HFmrEF) or preserved ejection fraction (HFpEF) has not been widely addressed. The aim of this study was to assess whether the prognostic value of growth differentiation factor 15 (GDF-15) is superior to that of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with HFmrEF or HFpEF. Heart failure patients with either HFpEF or HFmrEF were included in the study. During their first visit to the HF unit, serum samples were obtained and stored for later assessment of GDF-15 and NT-proBNP concentrations. Patients were followed up by the HF unit. The main endpoint was all-cause mortality. A total of 311 patients, 90 (29%) HFmrEF and 221 (71%) HFpEF, were included. Mean age was 72 ± 13 years, and 136 (44%) were women. No differences were found in GDF-15 or NT-proBNP concentrations between both HF groups. During a median follow-up of 15 months (Q1-Q3: 9-30 months), 98 patients (32%) died, most (71%) of cardiovascular causes. Patients who died had higher median concentrations of GDF-15 (4085 vs. 2270 ng/L, P < 0.0001) and NT-proBNP (1984 vs. 1095 ng/L, P < 0.0001). A Cox multivariable model identified New York Heart Association Functional Class III (P = 0.04), systolic blood pressure (P = 0.01), left atrial diameter (P = 0.03), age. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/238784https://dx.doi.org/urn:doi:10.1002/ehf2.12621reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2387842026-06-06T12:50:31Z
dc.title.none.fl_str_mv Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fraction
title Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fraction
spellingShingle Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fraction
Mendez Fernandez, Ana Belen
GDF-15
HFmrEF
HFpEF
Chronic heart failure
Biomarkers
title_short Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fraction
title_full Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fraction
title_fullStr Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fraction
title_full_unstemmed Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fraction
title_sort Growth differentiation factor 15 as mortality predictor in heart failure patients with non-reduced ejection fraction
dc.creator.none.fl_str_mv Mendez Fernandez, Ana Belen
Ferrero-Gregori, Andreu|||0000-0001-6492-2416
García Osuna, Álvaro|||0000-0002-6682-0226
Mirabet Pérez, Sonia|||0000-0001-5955-2748
Pirla, Maria José
Cinca, Juan|||0000-0003-4819-4265
Ordóñez, J. (Jordi)|||0000-0003-4896-5832
Roig, Eulàlia|||0000-0002-3421-4985
author Mendez Fernandez, Ana Belen
author_facet Mendez Fernandez, Ana Belen
Ferrero-Gregori, Andreu|||0000-0001-6492-2416
García Osuna, Álvaro|||0000-0002-6682-0226
Mirabet Pérez, Sonia|||0000-0001-5955-2748
Pirla, Maria José
Cinca, Juan|||0000-0003-4819-4265
Ordóñez, J. (Jordi)|||0000-0003-4896-5832
Roig, Eulàlia|||0000-0002-3421-4985
author_role author
author2 Ferrero-Gregori, Andreu|||0000-0001-6492-2416
García Osuna, Álvaro|||0000-0002-6682-0226
Mirabet Pérez, Sonia|||0000-0001-5955-2748
Pirla, Maria José
Cinca, Juan|||0000-0003-4819-4265
Ordóñez, J. (Jordi)|||0000-0003-4896-5832
Roig, Eulàlia|||0000-0002-3421-4985
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GDF-15
HFmrEF
HFpEF
Chronic heart failure
Biomarkers
topic GDF-15
HFmrEF
HFpEF
Chronic heart failure
Biomarkers
description The prognostic value of biomarkers in patients with heart failure (HF) and mid-range (HFmrEF) or preserved ejection fraction (HFpEF) has not been widely addressed. The aim of this study was to assess whether the prognostic value of growth differentiation factor 15 (GDF-15) is superior to that of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with HFmrEF or HFpEF. Heart failure patients with either HFpEF or HFmrEF were included in the study. During their first visit to the HF unit, serum samples were obtained and stored for later assessment of GDF-15 and NT-proBNP concentrations. Patients were followed up by the HF unit. The main endpoint was all-cause mortality. A total of 311 patients, 90 (29%) HFmrEF and 221 (71%) HFpEF, were included. Mean age was 72 ± 13 years, and 136 (44%) were women. No differences were found in GDF-15 or NT-proBNP concentrations between both HF groups. During a median follow-up of 15 months (Q1-Q3: 9-30 months), 98 patients (32%) died, most (71%) of cardiovascular causes. Patients who died had higher median concentrations of GDF-15 (4085 vs. 2270 ng/L, P < 0.0001) and NT-proBNP (1984 vs. 1095 ng/L, P < 0.0001). A Cox multivariable model identified New York Heart Association Functional Class III (P = 0.04), systolic blood pressure (P = 0.01), left atrial diameter (P = 0.03), age.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/238784
https://dx.doi.org/urn:doi:10.1002/ehf2.12621
url https://ddd.uab.cat/record/238784
https://dx.doi.org/urn:doi:10.1002/ehf2.12621
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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