BACE-1, PS-1 and sAPPβ levels are increased in plasma from sporadic inclusion body myositis patients: surrogate biomarkers among inflammatory myopathies
Sporadic inclusion body myositis (sIBM) is a rare disease which is difficult to diagnose. Muscle biopsy provides three prominent pathological findings: inflammation, mitochondrial abnormalities and fibber degeneration represented by the accumulation of protein depots constituted by β-amyloid peptide...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/219049 |
| Acceso en línea: | https://hdl.handle.net/2445/219049 |
| Access Level: | acceso abierto |
| Palabra clave: | Miositis Biòpsia Inflamació Myositis Biopsy Inflammation |
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BACE-1, PS-1 and sAPPβ levels are increased in plasma from sporadic inclusion body myositis patients: surrogate biomarkers among inflammatory myopathiesVillarroya i Gombau, FrancescCatalán García, MarcGarrabou Tornos, GlòriaMorén Núñez, ConstanzaGuitart Mampel, MarionaGonzález Casacuberta, IngridHernando, AdrianaGallego Escuredo, José MiguelYubero Siles, DèliaMontero, RaquelSelva O'Callaghan, AlbertCardellach, FrancescGrau, Josep MariaMiositisBiòpsiaInflamacióMyositisBiopsyInflammationSporadic inclusion body myositis (sIBM) is a rare disease which is difficult to diagnose. Muscle biopsy provides three prominent pathological findings: inflammation, mitochondrial abnormalities and fibber degeneration represented by the accumulation of protein depots constituted by β-amyloid peptide, among others. We aim to perform a screening in plasma of circulating molecules related to the putative etiopathogenesis of sIBM to determine potential surrogate biomarkers for diagnosis. Plasma from 21 sIBM patients and 20 age and gender-paired healthy controls were collected and stored at -80ºC. An additional population of patients with non-sIBM inflammatory myopathies was also included (9 patients with dermatomyositis and 5 with polymyositis). Circulating levels of inflammatory cytokines (IL-6 and TNF-α), mitochondrial-related molecules (free plasmatic mtDNA, FGF-21 and CoQ) and amyloidogenic-related molecules (BACE-1, PS-1 and sAPPβ) were assessed with magnetic bead-based assays, rt-PCR, ELISA and HPLC. Despite remarkable trends towards altered plasmatic expression of inflammatory and mitochondrial molecules (increased IL-6, TNF-α, circulating mtDNA and FGF-21 levels and decreased content in CoQ), only amyloidogenic degenerative markers including BACE-1, PS-1 and sAPPβ levels were significantly increased in plasma from sIBM patients compared to controls and other patients with non-sIBM inflammatory myopathies (p<0.05). Inflammatory, mitochondrial and amyloidogenic degeneration markers are altered in plasma of sIBM patients confirming their etiopathological implication in the disease. Sensitivity and specificity analysis show that BACE-1, PS-1 and sAPPβ represent a good predictive non-invasive tool for the diagnosis of sIBM, especially in distinguishing this disease from polymyositis.BioMed Central2025202520152025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/219049Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.2119/molmed.2015.00168Molecular Medicine, 2015, vol. 21, num.1, p. 817-823https://doi.org/10.2119/molmed.2015.00168(c) Molecular Medicine, 2015info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2190492026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
BACE-1, PS-1 and sAPPβ levels are increased in plasma from sporadic inclusion body myositis patients: surrogate biomarkers among inflammatory myopathies |
| title |
BACE-1, PS-1 and sAPPβ levels are increased in plasma from sporadic inclusion body myositis patients: surrogate biomarkers among inflammatory myopathies |
| spellingShingle |
BACE-1, PS-1 and sAPPβ levels are increased in plasma from sporadic inclusion body myositis patients: surrogate biomarkers among inflammatory myopathies Villarroya i Gombau, Francesc Miositis Biòpsia Inflamació Myositis Biopsy Inflammation |
| title_short |
BACE-1, PS-1 and sAPPβ levels are increased in plasma from sporadic inclusion body myositis patients: surrogate biomarkers among inflammatory myopathies |
| title_full |
BACE-1, PS-1 and sAPPβ levels are increased in plasma from sporadic inclusion body myositis patients: surrogate biomarkers among inflammatory myopathies |
| title_fullStr |
BACE-1, PS-1 and sAPPβ levels are increased in plasma from sporadic inclusion body myositis patients: surrogate biomarkers among inflammatory myopathies |
| title_full_unstemmed |
BACE-1, PS-1 and sAPPβ levels are increased in plasma from sporadic inclusion body myositis patients: surrogate biomarkers among inflammatory myopathies |
| title_sort |
BACE-1, PS-1 and sAPPβ levels are increased in plasma from sporadic inclusion body myositis patients: surrogate biomarkers among inflammatory myopathies |
| dc.creator.none.fl_str_mv |
Villarroya i Gombau, Francesc Catalán García, Marc Garrabou Tornos, Glòria Morén Núñez, Constanza Guitart Mampel, Mariona González Casacuberta, Ingrid Hernando, Adriana Gallego Escuredo, José Miguel Yubero Siles, Dèlia Montero, Raquel Selva O'Callaghan, Albert Cardellach, Francesc Grau, Josep Maria |
| author |
Villarroya i Gombau, Francesc |
| author_facet |
Villarroya i Gombau, Francesc Catalán García, Marc Garrabou Tornos, Glòria Morén Núñez, Constanza Guitart Mampel, Mariona González Casacuberta, Ingrid Hernando, Adriana Gallego Escuredo, José Miguel Yubero Siles, Dèlia Montero, Raquel Selva O'Callaghan, Albert Cardellach, Francesc Grau, Josep Maria |
| author_role |
author |
| author2 |
Catalán García, Marc Garrabou Tornos, Glòria Morén Núñez, Constanza Guitart Mampel, Mariona González Casacuberta, Ingrid Hernando, Adriana Gallego Escuredo, José Miguel Yubero Siles, Dèlia Montero, Raquel Selva O'Callaghan, Albert Cardellach, Francesc Grau, Josep Maria |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Miositis Biòpsia Inflamació Myositis Biopsy Inflammation |
| topic |
Miositis Biòpsia Inflamació Myositis Biopsy Inflammation |
| description |
Sporadic inclusion body myositis (sIBM) is a rare disease which is difficult to diagnose. Muscle biopsy provides three prominent pathological findings: inflammation, mitochondrial abnormalities and fibber degeneration represented by the accumulation of protein depots constituted by β-amyloid peptide, among others. We aim to perform a screening in plasma of circulating molecules related to the putative etiopathogenesis of sIBM to determine potential surrogate biomarkers for diagnosis. Plasma from 21 sIBM patients and 20 age and gender-paired healthy controls were collected and stored at -80ºC. An additional population of patients with non-sIBM inflammatory myopathies was also included (9 patients with dermatomyositis and 5 with polymyositis). Circulating levels of inflammatory cytokines (IL-6 and TNF-α), mitochondrial-related molecules (free plasmatic mtDNA, FGF-21 and CoQ) and amyloidogenic-related molecules (BACE-1, PS-1 and sAPPβ) were assessed with magnetic bead-based assays, rt-PCR, ELISA and HPLC. Despite remarkable trends towards altered plasmatic expression of inflammatory and mitochondrial molecules (increased IL-6, TNF-α, circulating mtDNA and FGF-21 levels and decreased content in CoQ), only amyloidogenic degenerative markers including BACE-1, PS-1 and sAPPβ levels were significantly increased in plasma from sIBM patients compared to controls and other patients with non-sIBM inflammatory myopathies (p<0.05). Inflammatory, mitochondrial and amyloidogenic degeneration markers are altered in plasma of sIBM patients confirming their etiopathological implication in the disease. Sensitivity and specificity analysis show that BACE-1, PS-1 and sAPPβ represent a good predictive non-invasive tool for the diagnosis of sIBM, especially in distinguishing this disease from polymyositis. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/219049 |
| url |
https://hdl.handle.net/2445/219049 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.2119/molmed.2015.00168 Molecular Medicine, 2015, vol. 21, num.1, p. 817-823 https://doi.org/10.2119/molmed.2015.00168 |
| dc.rights.none.fl_str_mv |
(c) Molecular Medicine, 2015 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) Molecular Medicine, 2015 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
7 p. application/pdf |
| dc.publisher.none.fl_str_mv |
BioMed Central |
| publisher.none.fl_str_mv |
BioMed Central |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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