Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses

11 Pág.

Detalhes bibliográficos
Autores: Martín-Acebes, M. A., Jiménez de Oya, Nereida, Saiz Calahorra, Juan Carlos
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/370580
Acesso em linha:http://hdl.handle.net/10261/370580
https://api.elsevier.com/content/abstract/scopus_id/85071006494
Access Level:acceso abierto
Palavra-chave:West Nile virus
Zika virus
Antiviral
Dengue virus
Flavivirus
Lipids
id ES_20d2ac60b397165e6ed8d4e8bd49797f
oai_identifier_str oai:digital.csic.es:10261/370580
network_acronym_str ES
network_name_str España
repository_id_str
spelling Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other FlavivirusesMartín-Acebes, M. A.Jiménez de Oya, NereidaSaiz Calahorra, Juan CarlosWest Nile virusZika virusAntiviralDengue virusFlavivirusLipids11 Pág.The Zika virus (ZIKV) is a mosquito-borne flavivirus that can lead to birth defects (microcephaly), ocular lesions and neurological disorders (Guillain-Barré syndrome). There is no licensed vaccine or antiviral treatment against ZIKV infection. The effort to understand the complex interactions of ZIKV with cellular networks contributes to the identification of novel host-directed antiviral (HDA) candidates. Among the cellular pathways involved in infection, lipid metabolism gains attention. In ZIKV-infected cells lipid metabolism attributed to intracellular membrane remodeling, virion morphogenesis, autophagy modulation, innate immunity and inflammation. The key roles played by the cellular structures associated with lipid metabolism, such as peroxisomes and lipid droplets, are starting to be deciphered. Consequently, there is a wide variety of lipid-related antiviral strategies that are currently under consideration, which include an inhibition of sterol regulatory element-binding proteins (SREBP), the activation of adenosine-monophosphate activated kinase (AMPK), an inhibition of acetyl-Coenzyme A carboxylase (ACC), interference with sphingolipid metabolism, blockage of intracellular cholesterol trafficking, or a treatment with cholesterol derivatives. Remarkably, most of the HDAs identified in these studies are also effective against flaviviruses other than ZIKV (West Nile virus and dengue virus), supporting their broad-spectrum effect. Considering that lipid metabolism is one of the main cellular pathways suitable for pharmacological intervention, the idea of repositioning drugs targeting lipid metabolism as antiviral candidates is gaining force.This research was funded by The Spanish Ministry of Economy and Competitiveness, grant number AGL2014-56518-JIN (to M.A.M-A.)Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Martín-Acebes, M. A. [0000-0001-6015-3613]Jiménez de Oya, Nereida [0000-0003-3129-813X]Saiz Calahorra, Juan Carlos [0000-0001-8269-5544]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/370580https://api.elsevier.com/content/abstract/scopus_id/85071006494reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//AGL2014-56518-JINDepartamento de Biotecnologíahttps://doi.org/10.3390/ph12020097Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3705802026-05-22T06:33:51Z
dc.title.none.fl_str_mv Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses
title Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses
spellingShingle Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses
Martín-Acebes, M. A.
West Nile virus
Zika virus
Antiviral
Dengue virus
Flavivirus
Lipids
title_short Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses
title_full Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses
title_fullStr Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses
title_full_unstemmed Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses
title_sort Lipid Metabolism as a Source of Druggable Targets for Antiviral Discovery against Zika and Other Flaviviruses
dc.creator.none.fl_str_mv Martín-Acebes, M. A.
Jiménez de Oya, Nereida
Saiz Calahorra, Juan Carlos
author Martín-Acebes, M. A.
author_facet Martín-Acebes, M. A.
Jiménez de Oya, Nereida
Saiz Calahorra, Juan Carlos
author_role author
author2 Jiménez de Oya, Nereida
Saiz Calahorra, Juan Carlos
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Martín-Acebes, M. A. [0000-0001-6015-3613]
Jiménez de Oya, Nereida [0000-0003-3129-813X]
Saiz Calahorra, Juan Carlos [0000-0001-8269-5544]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv West Nile virus
Zika virus
Antiviral
Dengue virus
Flavivirus
Lipids
topic West Nile virus
Zika virus
Antiviral
Dengue virus
Flavivirus
Lipids
description 11 Pág.
publishDate 2019
dc.date.none.fl_str_mv 2019
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/370580
https://api.elsevier.com/content/abstract/scopus_id/85071006494
url http://hdl.handle.net/10261/370580
https://api.elsevier.com/content/abstract/scopus_id/85071006494
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//AGL2014-56518-JIN
Departamento de Biotecnología
https://doi.org/10.3390/ph12020097
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404481070825472
score 15,81155

Registos relacionados