Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region

This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. ePVS in the basal ga...

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Autores: Ciampa, Iacopo, Operto, Grégory, Falcón, Carles, Minguillón Gil, Carolina, Castro de Moura, Manuel, Piñeyro, David, Esteller, Manel, Molinuevo, José Luis, Guigó Serra, Roderic, Navarro, Arcadi, Gispert, Juan Domingo, Vilor Tejedor, Natalia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/189407
Acceso en línea:https://hdl.handle.net/2445/189407
Access Level:acceso abierto
Palabra clave:Neurogenètica
Malaltia d'Alzheimer
Cervell
Anàlisi multivariable
Neurogenetics
Alzheimer's disease
Brain
Multivariate analysis
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spelling Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale regionCiampa, IacopoOperto, GrégoryFalcón, CarlesMinguillón Gil, CarolinaCastro de Moura, ManuelPiñeyro, DavidEsteller, ManelMolinuevo, José LuisGuigó Serra, RodericNavarro, ArcadiGispert, Juan DomingoVilor Tejedor, NataliaNeurogenèticaMalaltia d'AlzheimerCervellAnàlisi multivariableNeurogeneticsAlzheimer's diseaseBrainMultivariate analysisThis study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. ePVS in the basal ganglia (BG) and the centrum semiovale (CS) were assessed based on a validated visual rating scale. We used univariate and multivariate logistic regression models to investigate associations between ePVS in BG and CS with BIN1-rs744373, as well as APOE genotypes. We found a significant association of the BIN1-rs744373 polymorphism in the CS subscale (p value = 0.019; OR = 2.564), suggesting that G allele carriers have an increased risk of ePVS in comparison with A allele carriers. In stratified analysis by APOE-#4 status (carriers vs. non-carriers), these results remained significant only for '4 carriers (p value = 0.011; OR = 1.429). To our knowledge, the present study is the first suggesting that genetic predisposition for AD is associated with ePVS in CS. These findings provide evidence that underlying biological processes affecting AD may influence CS-ePVS.MDPI2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/189407Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/genes12060825Genes, 2021, vol. 12, num. 6https://doi.org/10.3390/genes12060825cc-by (c) Ciampa, Iacopo et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1894072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
title Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
spellingShingle Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
Ciampa, Iacopo
Neurogenètica
Malaltia d'Alzheimer
Cervell
Anàlisi multivariable
Neurogenetics
Alzheimer's disease
Brain
Multivariate analysis
title_short Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
title_full Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
title_fullStr Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
title_full_unstemmed Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
title_sort Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
dc.creator.none.fl_str_mv Ciampa, Iacopo
Operto, Grégory
Falcón, Carles
Minguillón Gil, Carolina
Castro de Moura, Manuel
Piñeyro, David
Esteller, Manel
Molinuevo, José Luis
Guigó Serra, Roderic
Navarro, Arcadi
Gispert, Juan Domingo
Vilor Tejedor, Natalia
author Ciampa, Iacopo
author_facet Ciampa, Iacopo
Operto, Grégory
Falcón, Carles
Minguillón Gil, Carolina
Castro de Moura, Manuel
Piñeyro, David
Esteller, Manel
Molinuevo, José Luis
Guigó Serra, Roderic
Navarro, Arcadi
Gispert, Juan Domingo
Vilor Tejedor, Natalia
author_role author
author2 Operto, Grégory
Falcón, Carles
Minguillón Gil, Carolina
Castro de Moura, Manuel
Piñeyro, David
Esteller, Manel
Molinuevo, José Luis
Guigó Serra, Roderic
Navarro, Arcadi
Gispert, Juan Domingo
Vilor Tejedor, Natalia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurogenètica
Malaltia d'Alzheimer
Cervell
Anàlisi multivariable
Neurogenetics
Alzheimer's disease
Brain
Multivariate analysis
topic Neurogenètica
Malaltia d'Alzheimer
Cervell
Anàlisi multivariable
Neurogenetics
Alzheimer's disease
Brain
Multivariate analysis
description This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. ePVS in the basal ganglia (BG) and the centrum semiovale (CS) were assessed based on a validated visual rating scale. We used univariate and multivariate logistic regression models to investigate associations between ePVS in BG and CS with BIN1-rs744373, as well as APOE genotypes. We found a significant association of the BIN1-rs744373 polymorphism in the CS subscale (p value = 0.019; OR = 2.564), suggesting that G allele carriers have an increased risk of ePVS in comparison with A allele carriers. In stratified analysis by APOE-#4 status (carriers vs. non-carriers), these results remained significant only for '4 carriers (p value = 0.011; OR = 1.429). To our knowledge, the present study is the first suggesting that genetic predisposition for AD is associated with ePVS in CS. These findings provide evidence that underlying biological processes affecting AD may influence CS-ePVS.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/189407
url https://hdl.handle.net/2445/189407
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/genes12060825
Genes, 2021, vol. 12, num. 6
https://doi.org/10.3390/genes12060825
dc.rights.none.fl_str_mv cc-by (c) Ciampa, Iacopo et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Ciampa, Iacopo et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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