The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar

African swine fever virus (ASFv) is one of the most challenging pathogens to affect both domestic and wild pigs. The disease has now spread to Europe and Asia, causing great damage to the pig industry. Although no commercial vaccine with which to control the disease is, as yet, available, some poten...

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Detalhes bibliográficos
Autores: Barroso Arévalo, Sandra, Sánchez-Vizcaíno Rodríguez, José Manuel, Cadenas Fernández, Estefanía, Barasona García-Arévalo, José Ángel
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/7374
Acesso em linha:https://hdl.handle.net/20.500.14352/7374
Access Level:acceso abierto
Palavra-chave:ASF
cytokines
IL-10
IFN-γ
wild boar
vaccine candidate
Ganado porcino
Nutrición y cuidado de los animales
3104.08 Porcinos
3109.06 Nutrición
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oai_identifier_str oai:docta.ucm.es:20.500.14352/7374
network_acronym_str ES
network_name_str España
repository_id_str
spelling The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild BoarBarroso Arévalo, SandraSánchez-Vizcaíno Rodríguez, José ManuelCadenas Fernández, EstefaníaBarasona García-Arévalo, José ÁngelASFcytokinesIL-10IFN-γwild boarvaccine candidateGanado porcinoNutrición y cuidado de los animales3104.08 Porcinos3109.06 NutriciónAfrican swine fever virus (ASFv) is one of the most challenging pathogens to affect both domestic and wild pigs. The disease has now spread to Europe and Asia, causing great damage to the pig industry. Although no commercial vaccine with which to control the disease is, as yet, available, some potential vaccine candidates have shown good results in terms of protection. However, little is known about the host immune mechanisms underlying that protection, especially in wild boar, which is the main reservoir of the disease in Europe. Here, we study the role played by two cytokines (IL-10 and IFN-γ) in wild boar orally inoculated with the attenuated vaccine candidate Lv17/WB/Rie1 and challenged with a virulent ASFv genotype II isolate. A group of naïve wild boar challenged with the latter isolate was also established as a control group. Our results showed that both cytokines play a key role in protecting the host against the challenge virus. While high levels of IL-10 in serum may trigger an immune system malfunctioning in challenged animals, the provision of stable levels of this cytokine over time may help to control the disease. This, together with high and timely induction of IFN-γ by the vaccine candidate, could help protect animals from fatal outcomes. Further studies should be conducted in order to support these preliminary results and confirm the role of these two cytokines as potential markers of the evolution of ASFV infection.Universidad Complutense de Madrid20212021-06-1520212021-06-15journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/7374reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/73742026-06-02T12:44:21Z
dc.title.none.fl_str_mv The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar
title The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar
spellingShingle The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar
Barroso Arévalo, Sandra
ASF
cytokines
IL-10
IFN-γ
wild boar
vaccine candidate
Ganado porcino
Nutrición y cuidado de los animales
3104.08 Porcinos
3109.06 Nutrición
title_short The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar
title_full The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar
title_fullStr The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar
title_full_unstemmed The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar
title_sort The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar
dc.creator.none.fl_str_mv Barroso Arévalo, Sandra
Sánchez-Vizcaíno Rodríguez, José Manuel
Cadenas Fernández, Estefanía
Barasona García-Arévalo, José Ángel
author Barroso Arévalo, Sandra
author_facet Barroso Arévalo, Sandra
Sánchez-Vizcaíno Rodríguez, José Manuel
Cadenas Fernández, Estefanía
Barasona García-Arévalo, José Ángel
author_role author
author2 Sánchez-Vizcaíno Rodríguez, José Manuel
Cadenas Fernández, Estefanía
Barasona García-Arévalo, José Ángel
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv ASF
cytokines
IL-10
IFN-γ
wild boar
vaccine candidate
Ganado porcino
Nutrición y cuidado de los animales
3104.08 Porcinos
3109.06 Nutrición
topic ASF
cytokines
IL-10
IFN-γ
wild boar
vaccine candidate
Ganado porcino
Nutrición y cuidado de los animales
3104.08 Porcinos
3109.06 Nutrición
description African swine fever virus (ASFv) is one of the most challenging pathogens to affect both domestic and wild pigs. The disease has now spread to Europe and Asia, causing great damage to the pig industry. Although no commercial vaccine with which to control the disease is, as yet, available, some potential vaccine candidates have shown good results in terms of protection. However, little is known about the host immune mechanisms underlying that protection, especially in wild boar, which is the main reservoir of the disease in Europe. Here, we study the role played by two cytokines (IL-10 and IFN-γ) in wild boar orally inoculated with the attenuated vaccine candidate Lv17/WB/Rie1 and challenged with a virulent ASFv genotype II isolate. A group of naïve wild boar challenged with the latter isolate was also established as a control group. Our results showed that both cytokines play a key role in protecting the host against the challenge virus. While high levels of IL-10 in serum may trigger an immune system malfunctioning in challenged animals, the provision of stable levels of this cytokine over time may help to control the disease. This, together with high and timely induction of IFN-γ by the vaccine candidate, could help protect animals from fatal outcomes. Further studies should be conducted in order to support these preliminary results and confirm the role of these two cytokines as potential markers of the evolution of ASFV infection.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-06-15
2021
2021-06-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/7374
url https://hdl.handle.net/20.500.14352/7374
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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