Mesoporous Bioactive Nanoparticles for Bone Tissue Applications

Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures th...

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Detalles Bibliográficos
Autores: Arcos Navarrete, Daniel, Portolés Pérez, María Teresa
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/101671
Acceso en línea:https://hdl.handle.net/20.500.14352/101671
Access Level:acceso abierto
Palabra clave:615:54
615.31
Mesoporous nanoparticles
Bioactivity
Bone regeneration
Drug delivery
Therapeutic ions
Cellular response
In vivo studies
Química
Química farmaceútica
23 Química
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oai_identifier_str oai:docta.ucm.es:20.500.14352/101671
network_acronym_str ES
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repository_id_str
spelling Mesoporous Bioactive Nanoparticles for Bone Tissue ApplicationsArcos Navarrete, DanielPortolés Pérez, María Teresa615:54615.31Mesoporous nanoparticlesBioactivityBone regenerationDrug deliveryTherapeutic ionsCellular responseIn vivo studiesQuímicaQuímica farmaceútica23 QuímicaResearch in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, including synthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date.Universidad Complutense de Madrid20232023-01-2120232023-01-21journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/101671reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1016712026-06-02T12:44:21Z
dc.title.none.fl_str_mv Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
spellingShingle Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
Arcos Navarrete, Daniel
615:54
615.31
Mesoporous nanoparticles
Bioactivity
Bone regeneration
Drug delivery
Therapeutic ions
Cellular response
In vivo studies
Química
Química farmaceútica
23 Química
title_short Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title_full Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title_fullStr Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title_full_unstemmed Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title_sort Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
dc.creator.none.fl_str_mv Arcos Navarrete, Daniel
Portolés Pérez, María Teresa
author Arcos Navarrete, Daniel
author_facet Arcos Navarrete, Daniel
Portolés Pérez, María Teresa
author_role author
author2 Portolés Pérez, María Teresa
author2_role author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615:54
615.31
Mesoporous nanoparticles
Bioactivity
Bone regeneration
Drug delivery
Therapeutic ions
Cellular response
In vivo studies
Química
Química farmaceútica
23 Química
topic 615:54
615.31
Mesoporous nanoparticles
Bioactivity
Bone regeneration
Drug delivery
Therapeutic ions
Cellular response
In vivo studies
Química
Química farmaceútica
23 Química
description Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, including synthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-21
2023
2023-01-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/101671
url https://hdl.handle.net/20.500.14352/101671
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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