Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin

The aim of this work was to formulate Santolina insularis essential oil-loaded nanocarriers, namely Penetration Enhancer containing Vesicles (PEVs), evaluate the physico-chemical features and stability, and gain insights into their ability to deliver the oil to the skin.S. insularis essential oil wa...

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Autores: Castangia, Ines, Manca, Maria Letizia, Caddeo, Carla, Maxia, Andrea, Murgia, Sergio, Pons Pons, Ramon, Demurtas, Davide, Pando, Daniel, Falconieri, Danilo, Péris, José Esteban, Fadda, Anna Maria, Manconi, Maria
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/130087
Acceso en línea:http://hdl.handle.net/10261/130087
Access Level:acceso abierto
Palabra clave:Ethylene/propylene glycol
Human keratinocytes
Phospholipid vesicles
Pig skin
Santolina insularis essential oil
Terpenes
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spelling Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skinCastangia, InesManca, Maria LetiziaCaddeo, CarlaMaxia, AndreaMurgia, SergioPons Pons, RamonDemurtas, DavidePando, DanielFalconieri, DaniloPéris, José EstebanFadda, Anna MariaManconi, MariaEthylene/propylene glycolHuman keratinocytesPhospholipid vesiclesPig skinSantolina insularis essential oilTerpenesThe aim of this work was to formulate Santolina insularis essential oil-loaded nanocarriers, namely Penetration Enhancer containing Vesicles (PEVs), evaluate the physico-chemical features and stability, and gain insights into their ability to deliver the oil to the skin.S. insularis essential oil was obtained by steam distillation, and was predominantly composed of terpenes, the most abundant being β-phellandrene (22.6%), myrcene (11.4%) and curcumenes (12.1%). Vesicles were prepared using phosphatidylcholine, and ethylene or propylene glycol were added to the water phase (10% (v/v)) to improve vesicle performances as delivery systems. Vesicles were deeply characterized by light scattering, cryogenic transmission electron microscopy and small/wide-angle X-ray scattering, the results showing polyhedral, faceted, unilamellar vesicles of ~115. nm in size. The presence of the glycols improved vesicle stability under accelerated ageing conditions, without changes in size or migration phenomena (e.g. sedimentation and creaming). Confocal laser scanning microscopy images of pig skin treated with S. insularis formulations displayed a penetration ability of PEVs greater than that of control liposomes. Moreover, all formulations showed a marked in vitro biocompatibility in human keratinocytes.These findings suggest that the nanoformulation may be of value in enhancing the delivery of S. insularis essential oil to the skin, where it can exert its biological activities.SAXS/WAXS experiments were performed at the BL11-NCD beamline at ALBA Synchrotron with the collaboration of ALBA staff. The beamtime at ALBA was kindly provided within the approved proposal n. 2013110789. This work was supported by a grant from Programma di Sviluppo Rurale 2007-2013 PSR Sardegna-MISURA 124, NANOFITOCARE, determinazione n. 4230/14. Dr. Pons acknowledges financial support from MINECO-CTQ2013-41514-P.Peer reviewedElsevierMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201620162015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/130087reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-41514-Phttp://www.sciencedirect.com/science/article/pii/S0927776515003239Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1300872026-05-22T06:33:51Z
dc.title.none.fl_str_mv Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin
title Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin
spellingShingle Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin
Castangia, Ines
Ethylene/propylene glycol
Human keratinocytes
Phospholipid vesicles
Pig skin
Santolina insularis essential oil
Terpenes
title_short Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin
title_full Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin
title_fullStr Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin
title_full_unstemmed Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin
title_sort Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin
dc.creator.none.fl_str_mv Castangia, Ines
Manca, Maria Letizia
Caddeo, Carla
Maxia, Andrea
Murgia, Sergio
Pons Pons, Ramon
Demurtas, Davide
Pando, Daniel
Falconieri, Danilo
Péris, José Esteban
Fadda, Anna Maria
Manconi, Maria
author Castangia, Ines
author_facet Castangia, Ines
Manca, Maria Letizia
Caddeo, Carla
Maxia, Andrea
Murgia, Sergio
Pons Pons, Ramon
Demurtas, Davide
Pando, Daniel
Falconieri, Danilo
Péris, José Esteban
Fadda, Anna Maria
Manconi, Maria
author_role author
author2 Manca, Maria Letizia
Caddeo, Carla
Maxia, Andrea
Murgia, Sergio
Pons Pons, Ramon
Demurtas, Davide
Pando, Daniel
Falconieri, Danilo
Péris, José Esteban
Fadda, Anna Maria
Manconi, Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ethylene/propylene glycol
Human keratinocytes
Phospholipid vesicles
Pig skin
Santolina insularis essential oil
Terpenes
topic Ethylene/propylene glycol
Human keratinocytes
Phospholipid vesicles
Pig skin
Santolina insularis essential oil
Terpenes
description The aim of this work was to formulate Santolina insularis essential oil-loaded nanocarriers, namely Penetration Enhancer containing Vesicles (PEVs), evaluate the physico-chemical features and stability, and gain insights into their ability to deliver the oil to the skin.S. insularis essential oil was obtained by steam distillation, and was predominantly composed of terpenes, the most abundant being β-phellandrene (22.6%), myrcene (11.4%) and curcumenes (12.1%). Vesicles were prepared using phosphatidylcholine, and ethylene or propylene glycol were added to the water phase (10% (v/v)) to improve vesicle performances as delivery systems. Vesicles were deeply characterized by light scattering, cryogenic transmission electron microscopy and small/wide-angle X-ray scattering, the results showing polyhedral, faceted, unilamellar vesicles of ~115. nm in size. The presence of the glycols improved vesicle stability under accelerated ageing conditions, without changes in size or migration phenomena (e.g. sedimentation and creaming). Confocal laser scanning microscopy images of pig skin treated with S. insularis formulations displayed a penetration ability of PEVs greater than that of control liposomes. Moreover, all formulations showed a marked in vitro biocompatibility in human keratinocytes.These findings suggest that the nanoformulation may be of value in enhancing the delivery of S. insularis essential oil to the skin, where it can exert its biological activities.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/130087
url http://hdl.handle.net/10261/130087
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2013-41514-P
http://www.sciencedirect.com/science/article/pii/S0927776515003239
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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