Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcoma

Cold atmospheric plasma (CAP) is a source of cell-damaging oxidant molecules that may be used as low-cost cancer treatment with minimal side effects. Liquids treated with cold plasma and enriched with oxidants are a modality for non-invasive treatment of internal tumors with cold plasma via injectio...

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Authors: Živanić, Milica|||0000-0002-4967-5709, Espona Noguera, Albert|||0000-0002-3681-030X, Verswyvel, Hanne, Smits, Evelien, Bogaerts, Annemie, Canal Barnils, Cristina|||0000-0002-3039-7462, Lin, Abraham
Format: article
Publication Date:2024
Country:España
Institution:Universitat Politècnica de Catalunya (UPC)
Repository:UPCommons. Portal del coneixement obert de la UPC
Language:English
OAI Identifier:oai:upcommons.upc.edu:2117/404410
Online Access:https://hdl.handle.net/2117/404410
https://dx.doi.org/10.1002/adfm.202312005
Access Level:Open access
Keyword:Osteosarcoma
Drug delivery systems
Cancer -- Immunotherapy
Drug delivery
Immunogenic cell death
Injectable hydrogels
Plasma medicine
Medicaments -- Modes d'administració
Càncer -- Immunoteràpia
Àrees temàtiques de la UPC::Enginyeria biomèdica
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oai_identifier_str oai:upcommons.upc.edu:2117/404410
network_acronym_str ES
network_name_str España
repository_id_str
spelling Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcomaŽivanić, Milica|||0000-0002-4967-5709Espona Noguera, Albert|||0000-0002-3681-030XVerswyvel, HanneSmits, EvelienBogaerts, AnnemieCanal Barnils, Cristina|||0000-0002-3039-7462Lin, AbrahamOsteosarcomaDrug delivery systemsCancer -- ImmunotherapyDrug deliveryImmunogenic cell deathInjectable hydrogelsOsteosarcomaPlasma medicineOsteosarcomaMedicaments -- Modes d'administracióCàncer -- ImmunoteràpiaÀrees temàtiques de la UPC::Enginyeria biomèdicaCold atmospheric plasma (CAP) is a source of cell-damaging oxidant molecules that may be used as low-cost cancer treatment with minimal side effects. Liquids treated with cold plasma and enriched with oxidants are a modality for non-invasive treatment of internal tumors with cold plasma via injection. However, liquids are easily diluted with body fluids which impedes high and localized delivery of oxidants to the target. As an alternative, plasma-treated hydrogels (PTH) emerge as vehicles for the precise delivery of oxidants. This study reports an optimal protocol for the preparation of injectable alginate PTH that ensures the preservation of plasma-generated oxidants. The generation, storage, and release of oxidants from the PTH are assessed. The efficacy of the alginate PTH in cancer treatment is demonstrated in the context of cancer cell cytotoxicity and immunogenicity–release of danger signals and phagocytosis by immature dendritic cells, up to now unexplored for PTH. These are shown in osteosarcoma, a hard-to-treat cancer. The study aims to consolidate PTH as a novel cold plasma treatment modality for non-invasive or postoperative tumor treatment. The results offer a rationale for further exploration of alginate-based PTHs as a versatile platform in biomedical engineering.Peer ReviewedObjectius de Desenvolupament Sostenible::3 - Salut i BenestarJohn Wiley & sons20242024-04-0320242024-03-13journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/404410https://dx.doi.org/10.1002/adfm.202312005reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4044102026-05-27T15:37:01Z
dc.title.none.fl_str_mv Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcoma
title Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcoma
spellingShingle Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcoma
Živanić, Milica|||0000-0002-4967-5709
Osteosarcoma
Drug delivery systems
Cancer -- Immunotherapy
Drug delivery
Immunogenic cell death
Injectable hydrogels
Osteosarcoma
Plasma medicine
Osteosarcoma
Medicaments -- Modes d'administració
Càncer -- Immunoteràpia
Àrees temàtiques de la UPC::Enginyeria biomèdica
title_short Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcoma
title_full Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcoma
title_fullStr Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcoma
title_full_unstemmed Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcoma
title_sort Injectable plasma-treated alginate hydrogel for oxidative stress delivery to induce immunogenic cell death in osteosarcoma
dc.creator.none.fl_str_mv Živanić, Milica|||0000-0002-4967-5709
Espona Noguera, Albert|||0000-0002-3681-030X
Verswyvel, Hanne
Smits, Evelien
Bogaerts, Annemie
Canal Barnils, Cristina|||0000-0002-3039-7462
Lin, Abraham
author Živanić, Milica|||0000-0002-4967-5709
author_facet Živanić, Milica|||0000-0002-4967-5709
Espona Noguera, Albert|||0000-0002-3681-030X
Verswyvel, Hanne
Smits, Evelien
Bogaerts, Annemie
Canal Barnils, Cristina|||0000-0002-3039-7462
Lin, Abraham
author_role author
author2 Espona Noguera, Albert|||0000-0002-3681-030X
Verswyvel, Hanne
Smits, Evelien
Bogaerts, Annemie
Canal Barnils, Cristina|||0000-0002-3039-7462
Lin, Abraham
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Osteosarcoma
Drug delivery systems
Cancer -- Immunotherapy
Drug delivery
Immunogenic cell death
Injectable hydrogels
Osteosarcoma
Plasma medicine
Osteosarcoma
Medicaments -- Modes d'administració
Càncer -- Immunoteràpia
Àrees temàtiques de la UPC::Enginyeria biomèdica
topic Osteosarcoma
Drug delivery systems
Cancer -- Immunotherapy
Drug delivery
Immunogenic cell death
Injectable hydrogels
Osteosarcoma
Plasma medicine
Osteosarcoma
Medicaments -- Modes d'administració
Càncer -- Immunoteràpia
Àrees temàtiques de la UPC::Enginyeria biomèdica
description Cold atmospheric plasma (CAP) is a source of cell-damaging oxidant molecules that may be used as low-cost cancer treatment with minimal side effects. Liquids treated with cold plasma and enriched with oxidants are a modality for non-invasive treatment of internal tumors with cold plasma via injection. However, liquids are easily diluted with body fluids which impedes high and localized delivery of oxidants to the target. As an alternative, plasma-treated hydrogels (PTH) emerge as vehicles for the precise delivery of oxidants. This study reports an optimal protocol for the preparation of injectable alginate PTH that ensures the preservation of plasma-generated oxidants. The generation, storage, and release of oxidants from the PTH are assessed. The efficacy of the alginate PTH in cancer treatment is demonstrated in the context of cancer cell cytotoxicity and immunogenicity–release of danger signals and phagocytosis by immature dendritic cells, up to now unexplored for PTH. These are shown in osteosarcoma, a hard-to-treat cancer. The study aims to consolidate PTH as a novel cold plasma treatment modality for non-invasive or postoperative tumor treatment. The results offer a rationale for further exploration of alginate-based PTHs as a versatile platform in biomedical engineering.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-04-03
2024
2024-03-13
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/404410
https://dx.doi.org/10.1002/adfm.202312005
url https://hdl.handle.net/2117/404410
https://dx.doi.org/10.1002/adfm.202312005
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & sons
publisher.none.fl_str_mv John Wiley & sons
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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