Performance characteristics of the whole-body discovery IQ PET/CT system

The aim of this study was to assess the physical performance of a new PET/CT system, the Discovery IQ with 5-ring detector blocks. Methods: Performance was measured using the National Electrical Manufacturers Association NU2-2012 methodology. Image quality was extended by accounting for different ac...

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Autores: Reynés-Llompart, Gabriel, Gámez, Cristina, Romero-Zayas, Immaculada, Rodríguez Bel, Laura, Vercher Conejero, José Luís, Martí-Climent, Josep M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/132887
Acceso en línea:https://hdl.handle.net/2445/132887
Access Level:acceso abierto
Palabra clave:Tumors
Diagnòstic per la imatge
Tomografia per emissió de positrons
Imatge corporal
Diagnostic imaging
Positron emission tomography
Body image
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spelling Performance characteristics of the whole-body discovery IQ PET/CT systemReynés-Llompart, GabrielGámez, CristinaRomero-Zayas, ImmaculadaRodríguez Bel, LauraVercher Conejero, José LuísMartí-Climent, Josep M.TumorsDiagnòstic per la imatgeTomografia per emissió de positronsImatge corporalTumorsDiagnostic imagingPositron emission tomographyBody imageThe aim of this study was to assess the physical performance of a new PET/CT system, the Discovery IQ with 5-ring detector blocks. Methods: Performance was measured using the National Electrical Manufacturers Association NU2-2012 methodology. Image quality was extended by accounting for different acquisition parameters (lesion-to-background ratios [8:1, 4:1, and 2:1] and acquisition times) and reconstruction algorithms (VUE-point HD [VPHD], VPHD with point-spread-function modeling [VPHD-S], and Q.Clear). Tomographic reconstruction was also assessed using a Jaszczak phantom. Additionally, 30 patient lesions were analyzed to account for differences in lesion volume and SUV quantification between reconstruction algorithms. Results: Spatial resolution ranged from 4.2 mm at 1 cm to 8.5 mm at 20 cm. Sensitivity measured at the center and at 10 cm was 22.8 and 20.4 kps/kBq, respectively. The noise-equivalent counting rate peak was 124 kcps at 9.1 kBq/cm3 The scatter fraction was 36.2%. The accuracy of correction for count losses and randoms was 3.9%. In the image quality test, contrast recovery for VPHD, VPHD-S, and Q.Clear ranged from 18%, 18%, and 13%, respectively (hot contrast; 10-mm sphere diameter; ratio, 2:1), to 68%, 67%, and 81%, respectively (cold contrast; 37-mm sphere diameter; ratio, 8:1). Background variability ranged from 3.4%, 3.0%, and 2.1%, respectively (ratio, 2:1), to 5.5%, 4.8%, and 3.7%, respectively (ratio, 8:1). On Q.Clear reconstruction, the decrease in the penalty term (β) increased the contrast recovery coefficients and background variability. With the Jaszczak phantom, image quality increased overall when a reconstruction algorithm modeling the point-spread function was used, and use of Q.Clear increased the signal-to-noise ratio. Lesions analyzed using VPHD-S and Q.Clear had an SUVmean of 6.5 ± 3 and 7 ± 3, respectively (P < 0.01), and an SUVmax of 11 ± 4.8 and 12 ± 4, respectively (P < 0.01). No significant difference in mean lesion volume was found between algorithms. Conclusion: Among the various Discovery bismuth germanium oxide-based PET/CT scanners, the IQ with 5-ring detector blocks has the highest overall performance, with improved sensitivity and counting rate performance. Q.Clear reconstruction improves the PET image quality, with higher recovery coefficients and lower background variability.The Society of Nuclear Medicine and Molecular Imaging2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/132887Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.2967/jnumed.116.185561Journal of Nuclear Medicine, 2017, vol. 58, num. 7, p. 1155-1161https://doi.org/10.2967/jnumed.116.185561(c) The Society of Nuclear Medicine and Molecular Imaging, 2017info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1328872026-05-27T06:46:51Z
dc.title.none.fl_str_mv Performance characteristics of the whole-body discovery IQ PET/CT system
title Performance characteristics of the whole-body discovery IQ PET/CT system
spellingShingle Performance characteristics of the whole-body discovery IQ PET/CT system
Reynés-Llompart, Gabriel
Tumors
Diagnòstic per la imatge
Tomografia per emissió de positrons
Imatge corporal
Tumors
Diagnostic imaging
Positron emission tomography
Body image
title_short Performance characteristics of the whole-body discovery IQ PET/CT system
title_full Performance characteristics of the whole-body discovery IQ PET/CT system
title_fullStr Performance characteristics of the whole-body discovery IQ PET/CT system
title_full_unstemmed Performance characteristics of the whole-body discovery IQ PET/CT system
title_sort Performance characteristics of the whole-body discovery IQ PET/CT system
dc.creator.none.fl_str_mv Reynés-Llompart, Gabriel
Gámez, Cristina
Romero-Zayas, Immaculada
Rodríguez Bel, Laura
Vercher Conejero, José Luís
Martí-Climent, Josep M.
author Reynés-Llompart, Gabriel
author_facet Reynés-Llompart, Gabriel
Gámez, Cristina
Romero-Zayas, Immaculada
Rodríguez Bel, Laura
Vercher Conejero, José Luís
Martí-Climent, Josep M.
author_role author
author2 Gámez, Cristina
Romero-Zayas, Immaculada
Rodríguez Bel, Laura
Vercher Conejero, José Luís
Martí-Climent, Josep M.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Tumors
Diagnòstic per la imatge
Tomografia per emissió de positrons
Imatge corporal
Tumors
Diagnostic imaging
Positron emission tomography
Body image
topic Tumors
Diagnòstic per la imatge
Tomografia per emissió de positrons
Imatge corporal
Tumors
Diagnostic imaging
Positron emission tomography
Body image
description The aim of this study was to assess the physical performance of a new PET/CT system, the Discovery IQ with 5-ring detector blocks. Methods: Performance was measured using the National Electrical Manufacturers Association NU2-2012 methodology. Image quality was extended by accounting for different acquisition parameters (lesion-to-background ratios [8:1, 4:1, and 2:1] and acquisition times) and reconstruction algorithms (VUE-point HD [VPHD], VPHD with point-spread-function modeling [VPHD-S], and Q.Clear). Tomographic reconstruction was also assessed using a Jaszczak phantom. Additionally, 30 patient lesions were analyzed to account for differences in lesion volume and SUV quantification between reconstruction algorithms. Results: Spatial resolution ranged from 4.2 mm at 1 cm to 8.5 mm at 20 cm. Sensitivity measured at the center and at 10 cm was 22.8 and 20.4 kps/kBq, respectively. The noise-equivalent counting rate peak was 124 kcps at 9.1 kBq/cm3 The scatter fraction was 36.2%. The accuracy of correction for count losses and randoms was 3.9%. In the image quality test, contrast recovery for VPHD, VPHD-S, and Q.Clear ranged from 18%, 18%, and 13%, respectively (hot contrast; 10-mm sphere diameter; ratio, 2:1), to 68%, 67%, and 81%, respectively (cold contrast; 37-mm sphere diameter; ratio, 8:1). Background variability ranged from 3.4%, 3.0%, and 2.1%, respectively (ratio, 2:1), to 5.5%, 4.8%, and 3.7%, respectively (ratio, 8:1). On Q.Clear reconstruction, the decrease in the penalty term (β) increased the contrast recovery coefficients and background variability. With the Jaszczak phantom, image quality increased overall when a reconstruction algorithm modeling the point-spread function was used, and use of Q.Clear increased the signal-to-noise ratio. Lesions analyzed using VPHD-S and Q.Clear had an SUVmean of 6.5 ± 3 and 7 ± 3, respectively (P < 0.01), and an SUVmax of 11 ± 4.8 and 12 ± 4, respectively (P < 0.01). No significant difference in mean lesion volume was found between algorithms. Conclusion: Among the various Discovery bismuth germanium oxide-based PET/CT scanners, the IQ with 5-ring detector blocks has the highest overall performance, with improved sensitivity and counting rate performance. Q.Clear reconstruction improves the PET image quality, with higher recovery coefficients and lower background variability.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/132887
url https://hdl.handle.net/2445/132887
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2967/jnumed.116.185561
Journal of Nuclear Medicine, 2017, vol. 58, num. 7, p. 1155-1161
https://doi.org/10.2967/jnumed.116.185561
dc.rights.none.fl_str_mv (c) The Society of Nuclear Medicine and Molecular Imaging, 2017
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) The Society of Nuclear Medicine and Molecular Imaging, 2017
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Society of Nuclear Medicine and Molecular Imaging
publisher.none.fl_str_mv The Society of Nuclear Medicine and Molecular Imaging
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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