Survival of infection with TEM β-lactamase-producing Escherichia coli with Pan-β-lactam resistance

Antimicrobial resistance is a critical global health issue, significantly contributing to patient mortality. Recent antibiotic developments have aimed to counteract carbapenemase-producing Enterobacterales; however, the impact of their use on the emergence of antibiotic resistance is unknown. This s...

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Detalles Bibliográficos
Autores: Rodríguez-Villodres, Ángel, Ortiz de la Rosa, José Manuel, Gálvez-Benítez, Lydia, Gascón, María Luisa, Peñalva, Germán, Dorado Pardo, Francisco J., Casimiro-Soriguer, Carlos S., Rodríguez Rodríguez, Marta, Amaya Villar, Rosario, Cisneros, José Miguel, Lepe, José A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/385200
Acceso en línea:http://hdl.handle.net/10261/385200
https://api.elsevier.com/content/abstract/scopus_id/85204396338
Access Level:acceso abierto
Palabra clave:Carbapenems
Cefiderocol
Escherichia coli
Pan-β-lactam resistance
TEM
β-lactam-β-lactamase inhibitors
Descripción
Sumario:Antimicrobial resistance is a critical global health issue, significantly contributing to patient mortality. Recent antibiotic developments have aimed to counteract carbapenemase-producing Enterobacterales; however, the impact of their use on the emergence of antibiotic resistance is unknown. This study investigates the first case of a non-carbapenemase-producing, pan-β-lactam-resistant Escherichia coli strain from a patient previously treated with ceftolozane-tazobactam and cefiderocol.

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