Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis

Low prosocial behavior in childhood has been consistently linked to later psychopathology, with evidence supporting the influence of both genetic and environmental factors on its development. Although neonatal DNA methylation (DNAm) has been found to prospectively associate with a range of psycholog...

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Authors: Luo, Mannan, Meehan, Alan J., Walton, Esther, Röder, Stefan, Herberth, Gunda, Zenclussen, Ana C., Cosín Tomàs, Marta, Sunyer Deu, Jordi, Mulder, Rosa H., Cortes Hidalgo, Andrea P., Bakermans-Kranenburg, Marian J., Felix, Janine Frédérique, Relton, Caroline, Suderman, Matthew, Pappa, Irene, Kok, Rianne, Tiemeier, Henning, van IJzendoorn, Marinus H., Barker, Edward D., Cecil, Charlotte A. M.
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/49256
Online Access:http://hdl.handle.net/10230/49256
http://dx.doi.org/10.1002/ajmg.b.32862
Access Level:Open access
Keyword:DNA methylation
Cord blood
Epigenome-wide association study
Meta-analysis
Prosocial behavior
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network_name_str España
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dc.title.none.fl_str_mv Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis
title Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis
spellingShingle Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis
Luo, Mannan
DNA methylation
Cord blood
Epigenome-wide association study
Meta-analysis
Prosocial behavior
title_short Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis
title_full Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis
title_fullStr Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis
title_full_unstemmed Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis
title_sort Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysis
dc.creator.none.fl_str_mv Luo, Mannan
Meehan, Alan J.
Walton, Esther
Röder, Stefan
Herberth, Gunda
Zenclussen, Ana C.
Cosín Tomàs, Marta
Sunyer Deu, Jordi
Mulder, Rosa H.
Cortes Hidalgo, Andrea P.
Bakermans-Kranenburg, Marian J.
Felix, Janine Frédérique
Relton, Caroline
Suderman, Matthew
Pappa, Irene
Kok, Rianne
Tiemeier, Henning
van IJzendoorn, Marinus H.
Barker, Edward D.
Cecil, Charlotte A. M.
author Luo, Mannan
author_facet Luo, Mannan
Meehan, Alan J.
Walton, Esther
Röder, Stefan
Herberth, Gunda
Zenclussen, Ana C.
Cosín Tomàs, Marta
Sunyer Deu, Jordi
Mulder, Rosa H.
Cortes Hidalgo, Andrea P.
Bakermans-Kranenburg, Marian J.
Felix, Janine Frédérique
Relton, Caroline
Suderman, Matthew
Pappa, Irene
Kok, Rianne
Tiemeier, Henning
van IJzendoorn, Marinus H.
Barker, Edward D.
Cecil, Charlotte A. M.
author_role author
author2 Meehan, Alan J.
Walton, Esther
Röder, Stefan
Herberth, Gunda
Zenclussen, Ana C.
Cosín Tomàs, Marta
Sunyer Deu, Jordi
Mulder, Rosa H.
Cortes Hidalgo, Andrea P.
Bakermans-Kranenburg, Marian J.
Felix, Janine Frédérique
Relton, Caroline
Suderman, Matthew
Pappa, Irene
Kok, Rianne
Tiemeier, Henning
van IJzendoorn, Marinus H.
Barker, Edward D.
Cecil, Charlotte A. M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DNA methylation
Cord blood
Epigenome-wide association study
Meta-analysis
Prosocial behavior
topic DNA methylation
Cord blood
Epigenome-wide association study
Meta-analysis
Prosocial behavior
description Low prosocial behavior in childhood has been consistently linked to later psychopathology, with evidence supporting the influence of both genetic and environmental factors on its development. Although neonatal DNA methylation (DNAm) has been found to prospectively associate with a range of psychological traits in childhood, its potential role in prosocial development has yet to be investigated. This study investigated prospective associations between cord blood DNAm at birth and low prosocial behavior within and across four longitudinal birth cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium. We examined (a) developmental trajectories of "chronic-low" versus "typical" prosocial behavior across childhood in a case-control design (N = 2,095), and (b) continuous "low prosocial" scores at comparable cross-cohort time-points (N = 2,121). Meta-analyses were performed to examine differentially methylated positions and regions. At the cohort-specific level, three CpGs were found to associate with chronic low prosocial behavior; however, none of these associations was replicated in another cohort. Meta-analysis revealed no epigenome-wide significant CpGs or regions. Overall, we found no evidence for associations between DNAm patterns at birth and low prosocial behavior across childhood. Findings highlight the importance of employing multi-cohort approaches to replicate epigenetic associations and reduce the risk of false positive discoveries.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/49256
http://dx.doi.org/10.1002/ajmg.b.32862
url http://hdl.handle.net/10230/49256
http://dx.doi.org/10.1002/ajmg.b.32862
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Am J Med Genet B Neuropsychiatr Genet. 2021;186(4):228-41
info:eu-repo/grantAgreement/EC/FP7/261357
info:eu-repo/grantAgreement/EC/FP7/308333
info:eu-repo/grantAgreement/EC/FP7/603794
info:eu-repo/grantAgreement/EC/H2020/634453
info:eu-repo/grantAgreement/EC/FP7/268479
info:eu-repo/grantAgreement/EC/H2020/669249
info:eu-repo/grantAgreement/EC/H2020/707404
info:eu-repo/grantAgreement/EC/H2020/848158
info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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spelling Neonatal DNA methylation and childhood low prosocial behavior: An epigenome-wide association meta-analysisLuo, MannanMeehan, Alan J.Walton, EstherRöder, StefanHerberth, GundaZenclussen, Ana C.Cosín Tomàs, MartaSunyer Deu, JordiMulder, Rosa H.Cortes Hidalgo, Andrea P.Bakermans-Kranenburg, Marian J.Felix, Janine FrédériqueRelton, CarolineSuderman, MatthewPappa, IreneKok, RianneTiemeier, Henningvan IJzendoorn, Marinus H.Barker, Edward D.Cecil, Charlotte A. M.DNA methylationCord bloodEpigenome-wide association studyMeta-analysisProsocial behaviorLow prosocial behavior in childhood has been consistently linked to later psychopathology, with evidence supporting the influence of both genetic and environmental factors on its development. Although neonatal DNA methylation (DNAm) has been found to prospectively associate with a range of psychological traits in childhood, its potential role in prosocial development has yet to be investigated. This study investigated prospective associations between cord blood DNAm at birth and low prosocial behavior within and across four longitudinal birth cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium. We examined (a) developmental trajectories of "chronic-low" versus "typical" prosocial behavior across childhood in a case-control design (N = 2,095), and (b) continuous "low prosocial" scores at comparable cross-cohort time-points (N = 2,121). Meta-analyses were performed to examine differentially methylated positions and regions. At the cohort-specific level, three CpGs were found to associate with chronic low prosocial behavior; however, none of these associations was replicated in another cohort. Meta-analysis revealed no epigenome-wide significant CpGs or regions. Overall, we found no evidence for associations between DNAm patterns at birth and low prosocial behavior across childhood. Findings highlight the importance of employing multi-cohort approaches to replicate epigenetic associations and reduce the risk of false positive discoveries.The epigenetic studies in INMA were mainly funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, CP18/00018), Spanish Ministry of Health (FIS-PI04/1436, FIS-PI08/1151 including FEDER funds, FIS-PI11/00610, FIS-FEDER-PI06/0867, FIS-FEDER-PI03-1615), Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430), EU Commission (261357-MeDALL: Mechanisms of the Development of ALLergy), and European Research Council (268479-BREATHE: BRain dEvelopment and Air polluTion ultrafine particles in scHool childrEn). MCT is funded by a Juan de la Cierva—Formación Postdoctoral Contract awarded by Ministry of Science and Innovation (FJC2018-036335-I). The 4, 7, and 11 year follow-up visits was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds; PI15/00118 incl. FEDER funds; CP16/00128 incl. FEDER funds; PI16/00118 incl. FEDER funds; PI16/00261 incl. FEDER funds; PI18/00547 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l'Alimentation de l'Environnement et du Travail (1262C0010; EST-2016 RF-21), EU Commission (261357, 308333, 603794 and 634453). We acknowledge support from the Spanish Ministry of Science and Innovation and State Research Agency through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.Wiley202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/49256http://dx.doi.org/10.1002/ajmg.b.32862reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAm J Med Genet B Neuropsychiatr Genet. 2021;186(4):228-41info:eu-repo/grantAgreement/EC/FP7/261357info:eu-repo/grantAgreement/EC/FP7/308333info:eu-repo/grantAgreement/EC/FP7/603794info:eu-repo/grantAgreement/EC/H2020/634453info:eu-repo/grantAgreement/EC/FP7/268479info:eu-repo/grantAgreement/EC/H2020/669249info:eu-repo/grantAgreement/EC/H2020/707404info:eu-repo/grantAgreement/EC/H2020/848158info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991© 2021 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/492562026-05-29T05:05:01Z
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