Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder

Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamica...

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Autores: Figueroa, Caroline A., Cabral, Joana, Mocking, Roeal J.T., Rapuano, Kristina M., Van Hartevelt, Tim J., Deco, Gustavo, Expert, Paul, Schene, Aart H., Kringelbach, Morten L., Ruhé, Henricus G.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/43618
Acesso em linha:http://hdl.handle.net/10230/43618
http://dx.doi.org/10.1002/hbm.24559
Access Level:acceso abierto
Palavra-chave:Cognitive control
Dynamic FC
Functional networks
Major depressive disorder
Resting-state fMRI
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network_name_str España
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dc.title.none.fl_str_mv Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder
title Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder
spellingShingle Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder
Figueroa, Caroline A.
Cognitive control
Dynamic FC
Functional networks
Major depressive disorder
Resting-state fMRI
title_short Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder
title_full Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder
title_fullStr Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder
title_full_unstemmed Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder
title_sort Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder
dc.creator.none.fl_str_mv Figueroa, Caroline A.
Cabral, Joana
Mocking, Roeal J.T.
Rapuano, Kristina M.
Van Hartevelt, Tim J.
Deco, Gustavo
Expert, Paul
Schene, Aart H.
Kringelbach, Morten L.
Ruhé, Henricus G.
author Figueroa, Caroline A.
author_facet Figueroa, Caroline A.
Cabral, Joana
Mocking, Roeal J.T.
Rapuano, Kristina M.
Van Hartevelt, Tim J.
Deco, Gustavo
Expert, Paul
Schene, Aart H.
Kringelbach, Morten L.
Ruhé, Henricus G.
author_role author
author2 Cabral, Joana
Mocking, Roeal J.T.
Rapuano, Kristina M.
Van Hartevelt, Tim J.
Deco, Gustavo
Expert, Paul
Schene, Aart H.
Kringelbach, Morten L.
Ruhé, Henricus G.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cognitive control
Dynamic FC
Functional networks
Major depressive disorder
Resting-state fMRI
topic Cognitive control
Dynamic FC
Functional networks
Major depressive disorder
Resting-state fMRI
description Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamically differs in remitted‐MDD patients vulnerable for new depressive episodes. Using a recently developed method to examine dynamic FC, we characterized re‐emerging FC states during rest in 51 antidepressant‐free MDD patients at high risk of recurrence (≥2 previous episodes), and 35 healthy controls. We examined differences in occurrence, duration, and switching profiles of FC states after neutral and sad mood induction. Remitted MDD patients showed a decreased probability of an FC state (p < 0.005) consisting of an extensive network connecting frontal areas—important for cognitive control—with default mode network, striatum, and salience areas, involved in emotional and self‐referential processing. Even when this FC state was observed in patients, it lasted shorter (p < 0.005) and was less likely to switch to a smaller prefrontal–striatum network (p < 0.005). Differences between patients and controls decreased after sad mood induction. Further, the duration of this FC state increased in remitted patients after sad mood induction but not in controls (p < 0.05). Our findings suggest reduced ability of remitted‐MDD patients, in neutral mood, to access a clinically relevant control network involved in the interplay between externally and internally oriented attention. When recovering from sad mood, remitted recurrent MDD appears to employ a compensatory mechanism to access this FC state. This study provides a novel neurobiological profile of MDD vulnerability.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/43618
http://dx.doi.org/10.1002/hbm.24559
url http://hdl.handle.net/10230/43618
http://dx.doi.org/10.1002/hbm.24559
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Human Brain Mapping. 2019 Jun 15;40(9):2771-86
info:eu-repo/grantAgreement/EC/H2020/615539
info:eu-repo/grantAgreement/ES/1PE/PSI2016‐75688‐P
info:eu-repo/grantAgreement/EC/H2020/785907
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Altered ability to access a clinically relevant control network in patients remitted from major depressive disorderFigueroa, Caroline A.Cabral, JoanaMocking, Roeal J.T.Rapuano, Kristina M.Van Hartevelt, Tim J.Deco, GustavoExpert, PaulSchene, Aart H.Kringelbach, Morten L.Ruhé, Henricus G.Cognitive controlDynamic FCFunctional networksMajor depressive disorderResting-state fMRINeurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined “static” functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamically differs in remitted‐MDD patients vulnerable for new depressive episodes. Using a recently developed method to examine dynamic FC, we characterized re‐emerging FC states during rest in 51 antidepressant‐free MDD patients at high risk of recurrence (≥2 previous episodes), and 35 healthy controls. We examined differences in occurrence, duration, and switching profiles of FC states after neutral and sad mood induction. Remitted MDD patients showed a decreased probability of an FC state (p < 0.005) consisting of an extensive network connecting frontal areas—important for cognitive control—with default mode network, striatum, and salience areas, involved in emotional and self‐referential processing. Even when this FC state was observed in patients, it lasted shorter (p < 0.005) and was less likely to switch to a smaller prefrontal–striatum network (p < 0.005). Differences between patients and controls decreased after sad mood induction. Further, the duration of this FC state increased in remitted patients after sad mood induction but not in controls (p < 0.05). Our findings suggest reduced ability of remitted‐MDD patients, in neutral mood, to access a clinically relevant control network involved in the interplay between externally and internally oriented attention. When recovering from sad mood, remitted recurrent MDD appears to employ a compensatory mechanism to access this FC state. This study provides a novel neurobiological profile of MDD vulnerability.This study is supported by unrestricted personal grants from the Academic Medical Centre to C.A.F. (AMC MD‐PhD Scholarship) and Dr. R.J.M. (AMC PhD Scholarship) and a dedicated grant from the Dutch Brain Foundation (Hersenstichting The Netherlands: 2009(2)‐72). Dr. J.C. was supported under the project NORTE‐01‐0145‐FEDER‐000023, by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). Dr. G.D. is supported by the Spanish Research Project PSI2016‐75688‐P (AEI/FEDER) and by the European Union's Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2). Dr. M.L.K. is supported by the ERC Consolidator Grant: CAREGIVING (no. 615539) and Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117). Dr. H.G.R. is supported by a NWO/ZonMW VENI‐Grant #016.126.059. Dr. PE acknowledges support from the EPSRC award EP/N014529/1 funding the EPSRC Centre for Mathematics of Precision Healthcare at Imperial.Wiley202020202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/43618http://dx.doi.org/10.1002/hbm.24559reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésHuman Brain Mapping. 2019 Jun 15;40(9):2771-86info:eu-repo/grantAgreement/EC/H2020/615539info:eu-repo/grantAgreement/ES/1PE/PSI2016‐75688‐Pinfo:eu-repo/grantAgreement/EC/H2020/785907© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/436182026-06-12T07:21:37Z
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