Disrupted functional connectivity in adolescent obesity

Background/objective: Obesity has been associated with brain alterations characterised by poorer interaction between a hypersensitive reward system and a comparatively weaker prefrontal-cognitive control system. These alterations may occur as early as in adolescence, but this notion remains unclear,...

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Autores: Moreno López, Laura, Contreras Rodríguez, Oren, Soriano Mas, Carles, Stamatakis, Emmanuel A., Verdejo García, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126904
Acceso en línea:https://hdl.handle.net/2445/126904
Access Level:acceso abierto
Palabra clave:Obesitat
Adolescents
Obesity
Teenagers
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spelling Disrupted functional connectivity in adolescent obesityMoreno López, LauraContreras Rodríguez, OrenSoriano Mas, CarlesStamatakis, Emmanuel A.Verdejo García, AntonioObesitatAdolescentsObesityTeenagersBackground/objective: Obesity has been associated with brain alterations characterised by poorer interaction between a hypersensitive reward system and a comparatively weaker prefrontal-cognitive control system. These alterations may occur as early as in adolescence, but this notion remains unclear, as no studies so far have examined global functional connectivity in adolescents with excess weight. Subjects/methods: We investigated functional connectivity in a sample of 60 adolescents with excess weight and 55 normal weight controls. We first identified parts of the brain displaying between-group global connectivity differences and then characterised the extent of the differences in functional network integrity and their association with reward sensitivity. Results: Adolescent obesity was linked to neuroadaptations in functional connectivity within brain hubs linked to interoception (insula), emotionalmemory (middle temporal gyrus) and cognitive control (dorsolateral prefrontal cortex) (pFWE < 0.05). The connectivity between the insula and the anterior cingulate cortex was reduced in comparison to controls, as was the connectivity between the middle temporal gyrus and the posterior cingulate cortex and cuneus/precuneus (pFWE < 0.05). Conversely, the middle temporal gyrus displayed increased connectivity with the orbitofrontal cortex (pFWE < 0.05). Critically, these networks were correlated with sensitivity to reward (p < 0.05). Conclusions: These findings suggest that adolescent obesity is linked to disrupted functional connectivity in brain networks relevant to maintaining balance between reward, emotional memories and cognitive control. Our findings may contribute to reconceptualization of obesity as a multi-layered brain disorder leading to compromised motivation and control, and provide a biological account to target prevention strategies for adolescent obesity.Elsevier2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/126904Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.nicl.2016.07.005Neuroimage: Clinical, 2016, vol. 12, p. 262-268https://doi.org/10.1016/j.nicl.2016.07.005cc by-nc-nd (c) Moreno Lopez et al., 2016http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1269042026-05-27T06:46:51Z
dc.title.none.fl_str_mv Disrupted functional connectivity in adolescent obesity
title Disrupted functional connectivity in adolescent obesity
spellingShingle Disrupted functional connectivity in adolescent obesity
Moreno López, Laura
Obesitat
Adolescents
Obesity
Teenagers
title_short Disrupted functional connectivity in adolescent obesity
title_full Disrupted functional connectivity in adolescent obesity
title_fullStr Disrupted functional connectivity in adolescent obesity
title_full_unstemmed Disrupted functional connectivity in adolescent obesity
title_sort Disrupted functional connectivity in adolescent obesity
dc.creator.none.fl_str_mv Moreno López, Laura
Contreras Rodríguez, Oren
Soriano Mas, Carles
Stamatakis, Emmanuel A.
Verdejo García, Antonio
author Moreno López, Laura
author_facet Moreno López, Laura
Contreras Rodríguez, Oren
Soriano Mas, Carles
Stamatakis, Emmanuel A.
Verdejo García, Antonio
author_role author
author2 Contreras Rodríguez, Oren
Soriano Mas, Carles
Stamatakis, Emmanuel A.
Verdejo García, Antonio
author2_role author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Adolescents
Obesity
Teenagers
topic Obesitat
Adolescents
Obesity
Teenagers
description Background/objective: Obesity has been associated with brain alterations characterised by poorer interaction between a hypersensitive reward system and a comparatively weaker prefrontal-cognitive control system. These alterations may occur as early as in adolescence, but this notion remains unclear, as no studies so far have examined global functional connectivity in adolescents with excess weight. Subjects/methods: We investigated functional connectivity in a sample of 60 adolescents with excess weight and 55 normal weight controls. We first identified parts of the brain displaying between-group global connectivity differences and then characterised the extent of the differences in functional network integrity and their association with reward sensitivity. Results: Adolescent obesity was linked to neuroadaptations in functional connectivity within brain hubs linked to interoception (insula), emotionalmemory (middle temporal gyrus) and cognitive control (dorsolateral prefrontal cortex) (pFWE < 0.05). The connectivity between the insula and the anterior cingulate cortex was reduced in comparison to controls, as was the connectivity between the middle temporal gyrus and the posterior cingulate cortex and cuneus/precuneus (pFWE < 0.05). Conversely, the middle temporal gyrus displayed increased connectivity with the orbitofrontal cortex (pFWE < 0.05). Critically, these networks were correlated with sensitivity to reward (p < 0.05). Conclusions: These findings suggest that adolescent obesity is linked to disrupted functional connectivity in brain networks relevant to maintaining balance between reward, emotional memories and cognitive control. Our findings may contribute to reconceptualization of obesity as a multi-layered brain disorder leading to compromised motivation and control, and provide a biological account to target prevention strategies for adolescent obesity.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126904
url https://hdl.handle.net/2445/126904
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.nicl.2016.07.005
Neuroimage: Clinical, 2016, vol. 12, p. 262-268
https://doi.org/10.1016/j.nicl.2016.07.005
dc.rights.none.fl_str_mv cc by-nc-nd (c) Moreno Lopez et al., 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Moreno Lopez et al., 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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