Neural correlates of human fear conditioning and sources of variability in 2199 individuals

Pavlovian fear conditioning is a fundamental process in both health and disease. We investigate its neural correlates and sources of variability using harmonized functional magnetic resonance imaging data from 2199 individuals across nine countries, including 1888 healthy individuals and 311 with an...

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Autores: Radua, Joaquim|||0000-0003-1240-5438, Savage, Hannah S., Vilajosana, Enric, Jamieson, Alec|||0000-0002-5598-0240, Abler, Birgit, Åhs, Fredrik, Beckers, Tom|||0000-0002-9581-1505, Cardoner, Narcís|||0000-0001-9633-0888, Cisler, Josh M., Diniz, Juliana B., Bach, Dominik R.|||0000-0003-3717-2036, Elsenbruch, Sigrid|||0000-0002-6528-2665, Greening, Steven G.|||0000-0003-4578-4139, Holt, Daphne J., Kaczkurkin, Antonia N.|||0000-0002-0943-3094, Keil, Andreas|||0000-0002-4064-1924, Kindt, Merel|||0000-0001-7989-3195, Koch, Kathrin|||0000-0003-4664-8016, LaBar, Kevin S.|||0000-0002-8253-5417, Lam, Charlene L., Larson, Christine L.|||0000-0002-1359-6080, Lonsdorf, Tina B.|||0000-0003-1501-4846, Merz, Christian J.|||0000-0001-5679-6595, McLaughlin, Katie A.|||0000-0002-1362-2410, Neria, Yuval, Pine, Daniel S., van Reekum, Carien M.|||0000-0002-1516-1101, Shackman, Alexander J.|||0000-0002-3629-4704, Soriano-Mas, Carles|||0000-0003-4574-6597, Spoormaker, Victor I., Stout, Daniel M., Straube, Benjamin|||0000-0002-9837-0944, Straube, Thomas, Tuominen, Lauri, Visser, Renée M.|||0000-0003-0376-8165, Ahumada, Laura|||0000-0002-9353-2457, Arolt, Volker|||0000-0002-2445-9778, Batistuzzo, Marcelo C.|||0000-0003-1347-8241, Bazán, Paulo R.|||0000-0003-2202-0494, Biggs, Emma E., Cano, Marta|||0000-0003-0675-9483, Chavarría-Elizondo, Pamela|||0000-0002-8177-3771, Cooper, Samuel E.|||0000-0001-9563-1750, Dannlowski, Udo|||0000-0002-0623-3759, De la Peña-Arteaga, Víctor|||0000-0001-8627-2653, DeCross, Stephanie N.|||0000-0001-8993-4413, Domschke, Katharina|||0000-0002-2550-9132, Ehlers, Mana R., Graner, John L.|||0000-0002-5465-7193, Hamm, Alfons O., Herrmann, Martin J.|||0000-0001-9970-2122, Huggins, Ashley A.|||0000-0001-7936-2116, Icenhour, Adriane, Juaneda-Seguí, Asier, Junghoefer, Markus|||0000-0002-8532-2986, Kircher, Tilo|||0000-0002-2514-2625, Koelkebeck, Katja|||0000-0002-0469-3997, Kuhn, Manuel|||0000-0003-2210-9130, Labrenz, Franziska|||0000-0001-7284-3451, Lissek, Shmuel M., Lotze, Martin|||0000-0003-4519-4956, Lueken, Ulrike|||0000-0003-1564-4012, Margraf, Jürgen|||0000-0001-5207-7016, Martínez-Zalacaín, Ignacio|||0000-0002-4036-0284, Moeck, Robert, Morriss, Jayne|||0000-0002-7928-9673, Ortuño, María|||0000-0002-7730-6054, Pittig, Andre|||0000-0003-3787-9576, Porta-Casteràs, Daniel|||0000-0002-3921-3607, Richter, Jan|||0000-0002-7127-6990, Ridderbusch, Isabelle C., Rief, Winfried|||0000-0002-7019-2250, Roesmann, Kati|||0000-0001-6940-3551, Rosén, Jörgen|||0000-0002-3688-3859, Rußmann, Alena N., Sjouwerman, Rachel, Spohrs, Jennifer, Ströhle, Andreas|||0000-0003-0935-3702, Suarez-Jimenez, Benjamin|||0000-0002-4765-2458, Ulrich, Martin|||0000-0002-1237-0426, Wittchen, Hans-Ulrich|||0000-0002-6311-7711, Zhu, Xi, Waller, Lea|||0000-0002-3239-6957, Walter, Henrik|||0000-0002-9403-6121, Thompson, Paul M.|||0000-0002-4720-8867, Bas-Hoogendam, Janna Marie|||0000-0001-8982-1670, Groenewold, Nynke A.|||0000-0002-0865-8427, Stein, Dan J.|||0000-0001-7218-7810, Van der Wee, Nic J., Dunsmoor, Joseph E.|||0000-0002-5448-6873, Marquand, Andre F.|||0000-0001-5903-203X, Fullana, Miguel|||0000-0003-3863-5223
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:319824
Acceso en línea:https://ddd.uab.cat/record/319824
https://dx.doi.org/urn:doi:10.1038/s41467-025-63078-x
Access Level:acceso abierto
Palabra clave:Neural circuits
Fear conditioning
Descripción
Sumario:Pavlovian fear conditioning is a fundamental process in both health and disease. We investigate its neural correlates and sources of variability using harmonized functional magnetic resonance imaging data from 2199 individuals across nine countries, including 1888 healthy individuals and 311 with anxiety-related or depressive disorders. Using mega-analysis and normative modeling, we show that fear conditioning consistently engages brain regions within the "central autonomic-interoceptive" or "salience" network. Several task variables strongly modulate activity in these regions, contributing to variability in neural responses. Additionally, brain activation patterns differ between healthy individuals and those with anxiety-related or depressive disorders, with distinct profiles characterizing specific disorders such as post-traumatic stress disorder and obsessive-compulsive disorder. While the neural correlates of fear conditioning are highly generalizable at the population level, variability arises from differences in task design and clinical status, highlighting the importance of methodological diversity in capturing fear learning mechanisms.

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