The genetic impact of an Ebola outbreak on a wild gorilla population

Background: Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees have also succumbed to the fatal virus. The 2004 outbreak at the Odzala-Kokoua National Park (Republic of Congo) alone caused a severe decline in th...

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Autores: Fontsere, Claudia|||0000-0003-2233-6026, Frandsen, Peter, Hernandez Rodriguez, Jessica, Niemann, Jonas|||0000-0002-5153-100X, Hjorth Scharff-Olsen, Camilla, Vallet, Dominique, Le Gouar, Pascaline, Ménard, Nelly, Navarro, Arcadi|||0000-0003-2162-8246, Siegismund, Hans R., Hvilsom, Christina, Gilbert, M. Thomas P.|||0000-0002-5805-7195, Kuhlwilm, Martin|||0000-0002-0115-1797, Hughes, David, Marquès i Bonet, Tomàs|||0000-0002-5597-3075
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:250219
Acceso en línea:https://ddd.uab.cat/record/250219
https://dx.doi.org/urn:doi:10.1186/s12864-021-08025-y
Access Level:acceso abierto
Palabra clave:Ebola
Gorilla
Non-invasive samples
Candidate genes
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spelling The genetic impact of an Ebola outbreak on a wild gorilla populationFontsere, Claudia|||0000-0003-2233-6026Frandsen, PeterHernandez Rodriguez, JessicaNiemann, Jonas|||0000-0002-5153-100XHjorth Scharff-Olsen, CamillaVallet, DominiqueLe Gouar, PascalineMénard, NellyNavarro, Arcadi|||0000-0003-2162-8246Siegismund, Hans R.Hvilsom, ChristinaGilbert, M. Thomas P.|||0000-0002-5805-7195Kuhlwilm, Martin|||0000-0002-0115-1797Hughes, DavidMarquès i Bonet, Tomàs|||0000-0002-5597-3075EbolaGorillaNon-invasive samplesCandidate genesBackground: Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees have also succumbed to the fatal virus. The 2004 outbreak at the Odzala-Kokoua National Park (Republic of Congo) alone caused a severe decline in the resident western lowland gorilla (Gorilla gorilla gorilla) population, with a 95% mortality rate. Here, we explore the immediate genetic impact of the Ebola outbreak in the western lowland gorilla population. Results: Associations with survivorship were evaluated by utilizing DNA obtained from fecal samples from 16 gorilla individuals declared missing after the outbreak (non-survivors) and 15 individuals observed before and after the epidemic (survivors). We used a target enrichment approach to capture the sequences of 123 genes previously associated with immunology and Ebola virus resistance and additionally analyzed the gut microbiome which could influence the survival after an infection. Our results indicate no changes in the population genetic diversity before and after the Ebola outbreak, and no significant differences in microbial community composition between survivors and non-survivors. However, and despite the low power for an association analysis, we do detect six nominally significant missense mutations in four genes that might be candidate variants associated with an increased chance of survival. Conclusion: This study offers the first insight to the genetics of a wild great ape population before and after an Ebola outbreak using target capture experiments from fecal samples, and presents a list of candidate loci that may have facilitated their survival. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/250219https://dx.doi.org/urn:doi:10.1186/s12864-021-08025-yreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 676154Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BFU2015-68649-PEuropean Commission https://doi.org/10.13039/501100000780 864203Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 BFU2017-86471-PAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 CEX2018-000792-MAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-880Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PGC2018-101927-BI00open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2502192026-06-06T12:50:31Z
dc.title.none.fl_str_mv The genetic impact of an Ebola outbreak on a wild gorilla population
title The genetic impact of an Ebola outbreak on a wild gorilla population
spellingShingle The genetic impact of an Ebola outbreak on a wild gorilla population
Fontsere, Claudia|||0000-0003-2233-6026
Ebola
Gorilla
Non-invasive samples
Candidate genes
title_short The genetic impact of an Ebola outbreak on a wild gorilla population
title_full The genetic impact of an Ebola outbreak on a wild gorilla population
title_fullStr The genetic impact of an Ebola outbreak on a wild gorilla population
title_full_unstemmed The genetic impact of an Ebola outbreak on a wild gorilla population
title_sort The genetic impact of an Ebola outbreak on a wild gorilla population
dc.creator.none.fl_str_mv Fontsere, Claudia|||0000-0003-2233-6026
Frandsen, Peter
Hernandez Rodriguez, Jessica
Niemann, Jonas|||0000-0002-5153-100X
Hjorth Scharff-Olsen, Camilla
Vallet, Dominique
Le Gouar, Pascaline
Ménard, Nelly
Navarro, Arcadi|||0000-0003-2162-8246
Siegismund, Hans R.
Hvilsom, Christina
Gilbert, M. Thomas P.|||0000-0002-5805-7195
Kuhlwilm, Martin|||0000-0002-0115-1797
Hughes, David
Marquès i Bonet, Tomàs|||0000-0002-5597-3075
author Fontsere, Claudia|||0000-0003-2233-6026
author_facet Fontsere, Claudia|||0000-0003-2233-6026
Frandsen, Peter
Hernandez Rodriguez, Jessica
Niemann, Jonas|||0000-0002-5153-100X
Hjorth Scharff-Olsen, Camilla
Vallet, Dominique
Le Gouar, Pascaline
Ménard, Nelly
Navarro, Arcadi|||0000-0003-2162-8246
Siegismund, Hans R.
Hvilsom, Christina
Gilbert, M. Thomas P.|||0000-0002-5805-7195
Kuhlwilm, Martin|||0000-0002-0115-1797
Hughes, David
Marquès i Bonet, Tomàs|||0000-0002-5597-3075
author_role author
author2 Frandsen, Peter
Hernandez Rodriguez, Jessica
Niemann, Jonas|||0000-0002-5153-100X
Hjorth Scharff-Olsen, Camilla
Vallet, Dominique
Le Gouar, Pascaline
Ménard, Nelly
Navarro, Arcadi|||0000-0003-2162-8246
Siegismund, Hans R.
Hvilsom, Christina
Gilbert, M. Thomas P.|||0000-0002-5805-7195
Kuhlwilm, Martin|||0000-0002-0115-1797
Hughes, David
Marquès i Bonet, Tomàs|||0000-0002-5597-3075
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ebola
Gorilla
Non-invasive samples
Candidate genes
topic Ebola
Gorilla
Non-invasive samples
Candidate genes
description Background: Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees have also succumbed to the fatal virus. The 2004 outbreak at the Odzala-Kokoua National Park (Republic of Congo) alone caused a severe decline in the resident western lowland gorilla (Gorilla gorilla gorilla) population, with a 95% mortality rate. Here, we explore the immediate genetic impact of the Ebola outbreak in the western lowland gorilla population. Results: Associations with survivorship were evaluated by utilizing DNA obtained from fecal samples from 16 gorilla individuals declared missing after the outbreak (non-survivors) and 15 individuals observed before and after the epidemic (survivors). We used a target enrichment approach to capture the sequences of 123 genes previously associated with immunology and Ebola virus resistance and additionally analyzed the gut microbiome which could influence the survival after an infection. Our results indicate no changes in the population genetic diversity before and after the Ebola outbreak, and no significant differences in microbial community composition between survivors and non-survivors. However, and despite the low power for an association analysis, we do detect six nominally significant missense mutations in four genes that might be candidate variants associated with an increased chance of survival. Conclusion: This study offers the first insight to the genetics of a wild great ape population before and after an Ebola outbreak using target capture experiments from fecal samples, and presents a list of candidate loci that may have facilitated their survival.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/250219
https://dx.doi.org/urn:doi:10.1186/s12864-021-08025-y
url https://ddd.uab.cat/record/250219
https://dx.doi.org/urn:doi:10.1186/s12864-021-08025-y
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 676154
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BFU2015-68649-P
European Commission https://doi.org/10.13039/501100000780 864203
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 BFU2017-86471-P
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CEX2018-000792-M
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-880
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PGC2018-101927-BI00
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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