Treatment of hypertension during pregnancy
Introduction: Hypertension during pregnancy is one of the most frequent causes of maternal and fetal morbimortality. Perinatal and maternal death and disability rates have decreased by 30%, but hypertension during pregnancy has increased by approximately 10% in the last 30 years. This research aimed...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:312116 |
| Acceso en línea: | https://ddd.uab.cat/record/312116 https://dx.doi.org/urn:doi:10.3389/fphar.2024.1346357 |
| Access Level: | acceso abierto |
| Palabra clave: | Hypertension Pregnancy-induced Pregnancy outcome Antihypertensive agents Cohort studies Electronic health records EHR |
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Treatment of hypertension during pregnancya cohort of pregnancy episodes from the SIDIAP database, Catalonia, SpainLestón Vázquez, MartaGomez-Lumbreras, Ainhoa|||0000-0002-3916-0402Vilaplana-Carnerero, Carles|||0000-0003-3780-4996Vedia Urgell, Cristina|||0000-0003-4192-3779Morros, Rosa|||0000-0001-6752-8748Giner-Soriano, Maria|||0000-0003-3750-9233HypertensionPregnancy-inducedPregnancy outcomeAntihypertensive agentsCohort studiesElectronic health recordsEHRIntroduction: Hypertension during pregnancy is one of the most frequent causes of maternal and fetal morbimortality. Perinatal and maternal death and disability rates have decreased by 30%, but hypertension during pregnancy has increased by approximately 10% in the last 30 years. This research aimed to describe the pharmacological treatment and pregnancy outcomes of pregnancies with hypertension. Methods: We carried out an observational cohort study from the Information System for the Development of Research in Primary Care (SIDIAP) database. Pregnancy episodes with hypertension (ICD-10 codes for hypertension, I10-I15 and O10-O16) were identified. Antihypertensives were classified according to the ATC WHO classification: β-blocking agents (BBs), calcium channel blockers (CCBs), agents acting on the renin-angiotensin system (RAS agents), diuretics, and antiadrenergic agents. Exposure was defined for hypertension in pregnancies with ≥2 prescriptions during the pregnancy episode. Descriptive statistics for diagnoses and treatments were calculated. Results: In total, 4,839 pregnancies with hypertension diagnosis formed the study cohort. There were 1,944 (40.2%) pregnancies exposed to an antihypertensive medication. There were differences in mother's age, BMI, and alcohol intake between pregnancies exposed to antihypertensive medications and those not exposed. BBs were the most used (n = 1,160 pregnancy episodes; 59.7%), followed by RAS agents (n = 825, 42.4%), and CCBs were the least used (n = 347, 17.8%). Discussion: Pregnancies involving hypertension were exposed to antihypertensive medications, mostly BBs. We conduct a study focused on RAS agent use during pregnancy and its outcomes in the offspring. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/312116https://dx.doi.org/urn:doi:10.3389/fphar.2024.1346357reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3121162026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Treatment of hypertension during pregnancy a cohort of pregnancy episodes from the SIDIAP database, Catalonia, Spain |
| title |
Treatment of hypertension during pregnancy |
| spellingShingle |
Treatment of hypertension during pregnancy Lestón Vázquez, Marta Hypertension Pregnancy-induced Pregnancy outcome Antihypertensive agents Cohort studies Electronic health records EHR |
| title_short |
Treatment of hypertension during pregnancy |
| title_full |
Treatment of hypertension during pregnancy |
| title_fullStr |
Treatment of hypertension during pregnancy |
| title_full_unstemmed |
Treatment of hypertension during pregnancy |
| title_sort |
Treatment of hypertension during pregnancy |
| dc.creator.none.fl_str_mv |
Lestón Vázquez, Marta Gomez-Lumbreras, Ainhoa|||0000-0002-3916-0402 Vilaplana-Carnerero, Carles|||0000-0003-3780-4996 Vedia Urgell, Cristina|||0000-0003-4192-3779 Morros, Rosa|||0000-0001-6752-8748 Giner-Soriano, Maria|||0000-0003-3750-9233 |
| author |
Lestón Vázquez, Marta |
| author_facet |
Lestón Vázquez, Marta Gomez-Lumbreras, Ainhoa|||0000-0002-3916-0402 Vilaplana-Carnerero, Carles|||0000-0003-3780-4996 Vedia Urgell, Cristina|||0000-0003-4192-3779 Morros, Rosa|||0000-0001-6752-8748 Giner-Soriano, Maria|||0000-0003-3750-9233 |
| author_role |
author |
| author2 |
Gomez-Lumbreras, Ainhoa|||0000-0002-3916-0402 Vilaplana-Carnerero, Carles|||0000-0003-3780-4996 Vedia Urgell, Cristina|||0000-0003-4192-3779 Morros, Rosa|||0000-0001-6752-8748 Giner-Soriano, Maria|||0000-0003-3750-9233 |
| author2_role |
author author author author author |
| dc.subject.none.fl_str_mv |
Hypertension Pregnancy-induced Pregnancy outcome Antihypertensive agents Cohort studies Electronic health records EHR |
| topic |
Hypertension Pregnancy-induced Pregnancy outcome Antihypertensive agents Cohort studies Electronic health records EHR |
| description |
Introduction: Hypertension during pregnancy is one of the most frequent causes of maternal and fetal morbimortality. Perinatal and maternal death and disability rates have decreased by 30%, but hypertension during pregnancy has increased by approximately 10% in the last 30 years. This research aimed to describe the pharmacological treatment and pregnancy outcomes of pregnancies with hypertension. Methods: We carried out an observational cohort study from the Information System for the Development of Research in Primary Care (SIDIAP) database. Pregnancy episodes with hypertension (ICD-10 codes for hypertension, I10-I15 and O10-O16) were identified. Antihypertensives were classified according to the ATC WHO classification: β-blocking agents (BBs), calcium channel blockers (CCBs), agents acting on the renin-angiotensin system (RAS agents), diuretics, and antiadrenergic agents. Exposure was defined for hypertension in pregnancies with ≥2 prescriptions during the pregnancy episode. Descriptive statistics for diagnoses and treatments were calculated. Results: In total, 4,839 pregnancies with hypertension diagnosis formed the study cohort. There were 1,944 (40.2%) pregnancies exposed to an antihypertensive medication. There were differences in mother's age, BMI, and alcohol intake between pregnancies exposed to antihypertensive medications and those not exposed. BBs were the most used (n = 1,160 pregnancy episodes; 59.7%), followed by RAS agents (n = 825, 42.4%), and CCBs were the least used (n = 347, 17.8%). Discussion: Pregnancies involving hypertension were exposed to antihypertensive medications, mostly BBs. We conduct a study focused on RAS agent use during pregnancy and its outcomes in the offspring. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/312116 https://dx.doi.org/urn:doi:10.3389/fphar.2024.1346357 |
| url |
https://ddd.uab.cat/record/312116 https://dx.doi.org/urn:doi:10.3389/fphar.2024.1346357 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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