IL-12 gene therapy for cancer: in synergy with other immunotherapies
In preclinical models of cancer, gene therapy with interleukin 12 (IL-12) has reached unprecedented levels of success when combined with immunotherapy approaches such as gene transfer of other cytokines and/or chemokines, costimulatory molecules or adoptive cell therapy. These combinations have been...
| Autores: | , , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2001 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositório: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglês |
| OAI Identifier: | oai:dadun.unav.edu:10171/21779 |
| Acesso em linha: | https://hdl.handle.net/10171/21779 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Gene therapy Interleukin-12 Immunotherapy Cancer Chemokines Costimulation Dendritic cells |
| Resumo: | In preclinical models of cancer, gene therapy with interleukin 12 (IL-12) has reached unprecedented levels of success when combined with immunotherapy approaches such as gene transfer of other cytokines and/or chemokines, costimulatory molecules or adoptive cell therapy. These combinations have been found to produce synergistic rather than additive effects. Meanwhile, IL-12 gene therapy is beginning clinical testing as a single agent, but combination strategies are at hand. |
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