Gestational exercise increases male offspring's maximal workload capacity early in life

Mothers' antenatal strategies to improve the intrauterine environment can positively decrease pregnancy-derived intercurrences. By challenging the mother-fetus unit, gestational exercise (GE) favorably modulates deleterious stimuli, such as high-fat, high-sucrose (HFHS) diet-induced adverse con...

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Autores: Beleza, Jorge, Stevanovic-Silva, Jelena, Coxito, Pedro, Rocha, Hugo, Santos, Paulo, Ascensão, António, Torrella Guio, Joan Ramon, Magalhães, José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/193109
Acceso en línea:https://hdl.handle.net/2445/193109
Access Level:acceso abierto
Palabra clave:Epigenètica
Embriologia humana
Mitocondris
Epigenetics
Human embryology
Mitochondria
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spelling Gestational exercise increases male offspring's maximal workload capacity early in lifeBeleza, JorgeStevanovic-Silva, JelenaCoxito, PedroRocha, HugoSantos, PauloAscensão, AntónioTorrella Guio, Joan RamonMagalhães, JoséEpigenèticaEmbriologia humanaMitocondrisEpigeneticsHuman embryologyMitochondriaMothers' antenatal strategies to improve the intrauterine environment can positively decrease pregnancy-derived intercurrences. By challenging the mother-fetus unit, gestational exercise (GE) favorably modulates deleterious stimuli, such as high-fat, high-sucrose (HFHS) diet-induced adverse consequences for offspring. We aimed to analyze whether GE alters maternal HFHS-consumption effects on male offspring's maximal workload performance (MWP) and in some skeletal muscle (the soleus SOL and the tibialis anterior TA) biomarkers associated with mitochondrial biogenesis and oxidative fitness. Infant male Sprague-Dawley rats were divided into experimental groups according to mothers' dietary and/or exercise conditions: offspring of sedentary control diet-fed or HFHS-fed mothers (C-S or HFHS-S, respectively) and of exercised HFHS-fed mothers (HFHS-E). Although maternal HFHS did not significantly alter MWP, offspring from GE dams exhibited increased MWP. Lower SOL AMPk levels in HFHS-S were reverted by GE. SOL PGC-1α, OXPHOS C-I and C-IV subunits remained unaltered by maternal diet, although increased in HFHS-E offspring. Additionally, GE prevented maternal diet-related SOL miR-378a overexpression, while upregulated miR-34a expression. Decreased TA C-IV subunit expression in HFHS-S was reverted in HFHS-E, concomitantly with the downregulation of miR-338. In conclusion, GE in HFHS-fed dams increases the offspring's MWP, which seems to be associated with the intrauterine modulation of SM mitochondrial density and functional markers.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/193109Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ijms23073916International Journal of Molecular Sciences, 2022, vol. 23, p. 3916https://doi.org/10.3390/ijms23073916cc-by (c) Beleza, Jorge et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1931092026-05-27T06:46:51Z
dc.title.none.fl_str_mv Gestational exercise increases male offspring's maximal workload capacity early in life
title Gestational exercise increases male offspring's maximal workload capacity early in life
spellingShingle Gestational exercise increases male offspring's maximal workload capacity early in life
Beleza, Jorge
Epigenètica
Embriologia humana
Mitocondris
Epigenetics
Human embryology
Mitochondria
title_short Gestational exercise increases male offspring's maximal workload capacity early in life
title_full Gestational exercise increases male offspring's maximal workload capacity early in life
title_fullStr Gestational exercise increases male offspring's maximal workload capacity early in life
title_full_unstemmed Gestational exercise increases male offspring's maximal workload capacity early in life
title_sort Gestational exercise increases male offspring's maximal workload capacity early in life
dc.creator.none.fl_str_mv Beleza, Jorge
Stevanovic-Silva, Jelena
Coxito, Pedro
Rocha, Hugo
Santos, Paulo
Ascensão, António
Torrella Guio, Joan Ramon
Magalhães, José
author Beleza, Jorge
author_facet Beleza, Jorge
Stevanovic-Silva, Jelena
Coxito, Pedro
Rocha, Hugo
Santos, Paulo
Ascensão, António
Torrella Guio, Joan Ramon
Magalhães, José
author_role author
author2 Stevanovic-Silva, Jelena
Coxito, Pedro
Rocha, Hugo
Santos, Paulo
Ascensão, António
Torrella Guio, Joan Ramon
Magalhães, José
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epigenètica
Embriologia humana
Mitocondris
Epigenetics
Human embryology
Mitochondria
topic Epigenètica
Embriologia humana
Mitocondris
Epigenetics
Human embryology
Mitochondria
description Mothers' antenatal strategies to improve the intrauterine environment can positively decrease pregnancy-derived intercurrences. By challenging the mother-fetus unit, gestational exercise (GE) favorably modulates deleterious stimuli, such as high-fat, high-sucrose (HFHS) diet-induced adverse consequences for offspring. We aimed to analyze whether GE alters maternal HFHS-consumption effects on male offspring's maximal workload performance (MWP) and in some skeletal muscle (the soleus SOL and the tibialis anterior TA) biomarkers associated with mitochondrial biogenesis and oxidative fitness. Infant male Sprague-Dawley rats were divided into experimental groups according to mothers' dietary and/or exercise conditions: offspring of sedentary control diet-fed or HFHS-fed mothers (C-S or HFHS-S, respectively) and of exercised HFHS-fed mothers (HFHS-E). Although maternal HFHS did not significantly alter MWP, offspring from GE dams exhibited increased MWP. Lower SOL AMPk levels in HFHS-S were reverted by GE. SOL PGC-1α, OXPHOS C-I and C-IV subunits remained unaltered by maternal diet, although increased in HFHS-E offspring. Additionally, GE prevented maternal diet-related SOL miR-378a overexpression, while upregulated miR-34a expression. Decreased TA C-IV subunit expression in HFHS-S was reverted in HFHS-E, concomitantly with the downregulation of miR-338. In conclusion, GE in HFHS-fed dams increases the offspring's MWP, which seems to be associated with the intrauterine modulation of SM mitochondrial density and functional markers.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/193109
url https://hdl.handle.net/2445/193109
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms23073916
International Journal of Molecular Sciences, 2022, vol. 23, p. 3916
https://doi.org/10.3390/ijms23073916
dc.rights.none.fl_str_mv cc-by (c) Beleza, Jorge et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Beleza, Jorge et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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