Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta

11 páginas, 5 figuras, 4 tablas.

Detalles Bibliográficos
Autores: Valderas García, Elora, De La Vega, J., Álvarez Bardón, M., Castilla Gómez de Agüero, Verónica, Escarcena, Ricardo, López-Pérez, J. L., Rojo Vázquez, Francisco Antonio, San Feliciano, A., del Olmo, Esther, Balaña-Fouce, Rafael, Martínez Valladares, María
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/245330
Acceso en línea:http://hdl.handle.net/10261/245330
Access Level:acceso abierto
Palabra clave:Teladorsagia circumcincta
Anthelmintics
Aminoalcohol
Diamine
In vitro assays
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spelling Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcinctaValderas García, EloraDe La Vega, J.Álvarez Bardón, M.Castilla Gómez de Agüero, VerónicaEscarcena, RicardoLópez-Pérez, J. L.Rojo Vázquez, Francisco AntonioSan Feliciano, A.del Olmo, EstherBalaña-Fouce, RafaelMartínez Valladares, MaríaTeladorsagia circumcinctaAnthelminticsAminoalcoholDiamineIn vitro assays11 páginas, 5 figuras, 4 tablas.Gastrointestinal nematodes (GIN) infections are a serious problem in livestock production due to the great economic losses they cause. Their control is increasingly difficult because of the rapid development of drug resistance and the limited number of available drugs. Therefore, this study evaluated 18 aminoalcohol and 16 diamine derivatives against eggs, first and third stage larvae from a susceptible and a resistant isolate of Tela-dorsagia circumcincta collected from sheep. The effectiveness of the in vitro anthelmintic activity of the com-pounds was evaluated using three different procedures: Egg Hatch Test (EHT), Larval Mortality Test (LMT) and Larval Migration Inhibition Test (LMIT). Those compounds with activities higher than 90 % in the initial screening at 50 μM were selected to determine their half maximal effective concentration (EC50). In parallel, cytotoxicity assays were conducted on Caco2 and HepG2 cell lines to calculate Selectivity Indexes (SI) for each compound. The diamine 30 presented the best results in preventing egg hatching, displaying the lowest EC50 value (1.01 ±0.04 μM) of all compounds tested and the highest SI (21.21 vs. Caco-2 cells). For the LMIT, the diamine 34 showed the highest efficacy, with EC50 values of 2.67 ±0.08 and 3.02 ±0.09 μM on the susceptible and resistant isolate of the parasite, respectively.We are grateful to Dave Bartley, from Moredun Research Institute for providing the triple-resistant isolate of T. circumcincta. RE thank the RICET contract (E07D401988BR) EC Programs. Financial support came from MINECO: RETOS (AGL2016-79813-C2-1R/2R) and Junta de Castilla y León (JCyL) co-financed by FEDER, UE (LE020P17). EVG was funded by FPU16/03536; JV, VCGA and MAB are recipients of Junta de Castilla y Leon and European Social Found (ESF)’s Fellowships Scheme for Doctoral Training Programs. (JCYL-USAL35B, LE082-18, LE051-18, respectively) and MMV by the Spanish “Ramon y Cajal” Programme (Ministerio de Economía y Competitividad; RYC-2015-18368).Peer reviewedElsevier BVMinisterio de Economía y Competitividad (España)Junta de Castilla y LeónEuropean CommissionValderas García, Elora [0000-0002-9970-896X]Castilla Gómez de Agüero, Verónica [0000-0002-6797-0170]Martínez Valladares, María [0000-0002-3723-1895]Rojo Vázquez, Francisco A. [0000-0001-5913-0131]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/245330reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésInglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-79813-C2-1-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-79813-C2-2-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2015-18368http://dx.doi.org/10.1016/j.vetpar.2021.109496Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2453302026-05-22T06:33:51Z
dc.title.none.fl_str_mv Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta
title Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta
spellingShingle Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta
Valderas García, Elora
Teladorsagia circumcincta
Anthelmintics
Aminoalcohol
Diamine
In vitro assays
title_short Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta
title_full Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta
title_fullStr Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta
title_full_unstemmed Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta
title_sort Anthelmintic activity of aminoalcohol and diamine derivatives against the gastrointestinal nematode Teladorsagia circumcincta
dc.creator.none.fl_str_mv Valderas García, Elora
De La Vega, J.
Álvarez Bardón, M.
Castilla Gómez de Agüero, Verónica
Escarcena, Ricardo
López-Pérez, J. L.
Rojo Vázquez, Francisco Antonio
San Feliciano, A.
del Olmo, Esther
Balaña-Fouce, Rafael
Martínez Valladares, María
author Valderas García, Elora
author_facet Valderas García, Elora
De La Vega, J.
Álvarez Bardón, M.
Castilla Gómez de Agüero, Verónica
Escarcena, Ricardo
López-Pérez, J. L.
Rojo Vázquez, Francisco Antonio
San Feliciano, A.
del Olmo, Esther
Balaña-Fouce, Rafael
Martínez Valladares, María
author_role author
author2 De La Vega, J.
Álvarez Bardón, M.
Castilla Gómez de Agüero, Verónica
Escarcena, Ricardo
López-Pérez, J. L.
Rojo Vázquez, Francisco Antonio
San Feliciano, A.
del Olmo, Esther
Balaña-Fouce, Rafael
Martínez Valladares, María
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Junta de Castilla y León
European Commission
Valderas García, Elora [0000-0002-9970-896X]
Castilla Gómez de Agüero, Verónica [0000-0002-6797-0170]
Martínez Valladares, María [0000-0002-3723-1895]
Rojo Vázquez, Francisco A. [0000-0001-5913-0131]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Teladorsagia circumcincta
Anthelmintics
Aminoalcohol
Diamine
In vitro assays
topic Teladorsagia circumcincta
Anthelmintics
Aminoalcohol
Diamine
In vitro assays
description 11 páginas, 5 figuras, 4 tablas.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/245330
url http://hdl.handle.net/10261/245330
dc.language.none.fl_str_mv Inglés
Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-79813-C2-1-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-79813-C2-2-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2015-18368
http://dx.doi.org/10.1016/j.vetpar.2021.109496
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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