Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years

Background Serum cotinine has become the most widely used biomarker of secondhand smoke exposure (SHS) over time in all ages. The aim of this study was to review the serum cotinine cut-points used to classify children under 5 years as exposed to SHS. Methods A systematic review performed in the Pubm...

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Autores: Mourino, Nerea, Ruano-Raviña, Alberto, Varela Lema, Leonor, Fernández, Esteve|||0000-0003-4239-723X, López Medina, María José|||0000-0003-4402-2239, Santiago-Pérez, María Isolina, Rey-Brandariz, Julia, Giraldo Osorio, Alexandra, Pérez-Ríos, Mónica|||0000-0003-4456-6631
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:284197
Acesso em linha:https://ddd.uab.cat/record/284197
https://dx.doi.org/urn:doi:10.1371/journal.pone.0267319
Access Level:acceso abierto
Palavra-chave:Adolescent
Adult
Child
Child, Preschool
Cotinine
Environmental Exposure
Humans
Nutrition Surveys
Prevalence
Smoke-Free Policy
Tobacco Smoke Pollution
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spelling Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 yearsA systemic reviewMourino, NereaRuano-Raviña, AlbertoVarela Lema, LeonorFernández, Esteve|||0000-0003-4239-723XLópez Medina, María José|||0000-0003-4402-2239Santiago-Pérez, María IsolinaRey-Brandariz, JuliaGiraldo Osorio, AlexandraPérez-Ríos, Mónica|||0000-0003-4456-6631AdolescentAdultChildChild, PreschoolCotinineEnvironmental ExposureHumansNutrition SurveysPrevalenceSmoke-Free PolicyTobacco Smoke PollutionBackground Serum cotinine has become the most widely used biomarker of secondhand smoke exposure (SHS) over time in all ages. The aim of this study was to review the serum cotinine cut-points used to classify children under 5 years as exposed to SHS. Methods A systematic review performed in the Pubmed (MEDLINE) and EMBASE databases up to April 2021 was conducted using as key words "serum cotinine", "tobacco smoke pollution" (MeSH), "secondhand smoke", "environmental tobacco smoke" and "tobacco smoke exposure". Papers which assessed SHS exposure among children younger than 5 years old were included. The PRISMA 2020 guidelines were followed. Analysis was pre-registered in PROSPERO (registration number: CRD42021251263). Results 247 articles were identified and 51 fulfilled inclusion criteria. The selected studies were published between 1985-2020. Most of them included adolescents and adults. Only three assessed postnatal exposure exclusively among children under 5 years. None of the selected studies proposed age-specific cut-points for children < 5 years old. Cut-point values to assess SHS exposure ranged from 0.015 to 100 ng/ml. The most commonly used cut-point was 0.05 ng/ml, derived from the assay limit of detection used by the National Health and Nutrition Examination Survey (NHANES). Conclusions No studies have calculated serum cotinine age-specific cut-points to ascertained SHS exposure among children under 5 years old. Children's age-specific cut-points are warranted for health research and public health purposes aimed at accurately estimating the prevalence of SHS exposure and attributable burden of disease to such exposure, and at reinforcing 100% smoke-free policies worldwide, both in homes, private vehicles and public places. 22022-01-0120222022-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/284197https://dx.doi.org/urn:doi:10.1371/journal.pone.0267319reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2841972026-06-06T12:50:31Z
dc.title.none.fl_str_mv Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years
A systemic review
title Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years
spellingShingle Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years
Mourino, Nerea
Adolescent
Adult
Child
Child, Preschool
Cotinine
Environmental Exposure
Humans
Nutrition Surveys
Prevalence
Smoke-Free Policy
Tobacco Smoke Pollution
title_short Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years
title_full Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years
title_fullStr Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years
title_full_unstemmed Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years
title_sort Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years
dc.creator.none.fl_str_mv Mourino, Nerea
Ruano-Raviña, Alberto
Varela Lema, Leonor
Fernández, Esteve|||0000-0003-4239-723X
López Medina, María José|||0000-0003-4402-2239
Santiago-Pérez, María Isolina
Rey-Brandariz, Julia
Giraldo Osorio, Alexandra
Pérez-Ríos, Mónica|||0000-0003-4456-6631
author Mourino, Nerea
author_facet Mourino, Nerea
Ruano-Raviña, Alberto
Varela Lema, Leonor
Fernández, Esteve|||0000-0003-4239-723X
López Medina, María José|||0000-0003-4402-2239
Santiago-Pérez, María Isolina
Rey-Brandariz, Julia
Giraldo Osorio, Alexandra
Pérez-Ríos, Mónica|||0000-0003-4456-6631
author_role author
author2 Ruano-Raviña, Alberto
Varela Lema, Leonor
Fernández, Esteve|||0000-0003-4239-723X
López Medina, María José|||0000-0003-4402-2239
Santiago-Pérez, María Isolina
Rey-Brandariz, Julia
Giraldo Osorio, Alexandra
Pérez-Ríos, Mónica|||0000-0003-4456-6631
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Adolescent
Adult
Child
Child, Preschool
Cotinine
Environmental Exposure
Humans
Nutrition Surveys
Prevalence
Smoke-Free Policy
Tobacco Smoke Pollution
topic Adolescent
Adult
Child
Child, Preschool
Cotinine
Environmental Exposure
Humans
Nutrition Surveys
Prevalence
Smoke-Free Policy
Tobacco Smoke Pollution
description Background Serum cotinine has become the most widely used biomarker of secondhand smoke exposure (SHS) over time in all ages. The aim of this study was to review the serum cotinine cut-points used to classify children under 5 years as exposed to SHS. Methods A systematic review performed in the Pubmed (MEDLINE) and EMBASE databases up to April 2021 was conducted using as key words "serum cotinine", "tobacco smoke pollution" (MeSH), "secondhand smoke", "environmental tobacco smoke" and "tobacco smoke exposure". Papers which assessed SHS exposure among children younger than 5 years old were included. The PRISMA 2020 guidelines were followed. Analysis was pre-registered in PROSPERO (registration number: CRD42021251263). Results 247 articles were identified and 51 fulfilled inclusion criteria. The selected studies were published between 1985-2020. Most of them included adolescents and adults. Only three assessed postnatal exposure exclusively among children under 5 years. None of the selected studies proposed age-specific cut-points for children < 5 years old. Cut-point values to assess SHS exposure ranged from 0.015 to 100 ng/ml. The most commonly used cut-point was 0.05 ng/ml, derived from the assay limit of detection used by the National Health and Nutrition Examination Survey (NHANES). Conclusions No studies have calculated serum cotinine age-specific cut-points to ascertained SHS exposure among children under 5 years old. Children's age-specific cut-points are warranted for health research and public health purposes aimed at accurately estimating the prevalence of SHS exposure and attributable burden of disease to such exposure, and at reinforcing 100% smoke-free policies worldwide, both in homes, private vehicles and public places.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/284197
https://dx.doi.org/urn:doi:10.1371/journal.pone.0267319
url https://ddd.uab.cat/record/284197
https://dx.doi.org/urn:doi:10.1371/journal.pone.0267319
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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