E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases

Interstitial lung disease (ILD) constitutes the most critical comorbidity in autoimmune diseases (ADs) and its early diagnosis remains a challenge for clinicians. Accordingly, we evaluated whether E-selectin, ICAM-1, and ET-1, key molecules in endothelial damage, could be useful biomarkers for the d...

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Autores: Pulito-Cueto, V., Remuzgo-Martínez, S., Genre, F., Atienza-Mateo, B., Mora-Cuesta, V.M., Iturbe-Fernández, D., Lera-Gómez, L., Mora-Gil, M.S., Portilla, V., Corrales, A., Blanco, R., Cifrián, J.M., González-Gay Mantecón, Miguel Ángel, López-Mejías, R.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21374
Acceso en línea:https://portalcientifico.sergas.gal//documentos/64ec7b2be13d1f2d6d3b6a9a
http://hdl.handle.net/20.500.11940/21374
Access Level:acceso abierto
Palabra clave:Humans
Intercellular Adhesion Molecule-1
E-Selectin
Lung Diseases, Interstitial
Idiopathic Pulmonary Fibrosis
Autoimmune Diseases
Arthritis, Rheumatoid
Biomarkers
Scleroderma, Systemic
Lung
AS Santiago
CHUS
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oai_identifier_str oai:runa.sergas.gal:20.500.11940/21374
network_acronym_str ES
network_name_str España
repository_id_str
spelling E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune DiseasesPulito-Cueto, V.Remuzgo-Martínez, S.Genre, F.Atienza-Mateo, B.Mora-Cuesta, V.M.Iturbe-Fernández, D.Lera-Gómez, L.Mora-Gil, M.S.Portilla, V.Corrales, A.Blanco, R.Cifrián, J.M.González-Gay Mantecón, Miguel ÁngelLópez-Mejías, R.HumansIntercellular Adhesion Molecule-1E-SelectinLung Diseases, InterstitialIdiopathic Pulmonary FibrosisAutoimmune DiseasesArthritis, RheumatoidBiomarkersScleroderma, SystemicLungAS SantiagoCHUSInterstitial lung disease (ILD) constitutes the most critical comorbidity in autoimmune diseases (ADs) and its early diagnosis remains a challenge for clinicians. Accordingly, we evaluated whether E-selectin, ICAM-1, and ET-1, key molecules in endothelial damage, could be useful biomarkers for the detection of AD-ILD+. We recruited patients with rheumatoid arthritis (RA)-ILD+ (n = 21) and systemic sclerosis (SSc)-ILD+ (n = 21). We included comparison groups of patients: RA-ILD? (n = 25), SSc-ILD? (n = 20), and idiopathic pulmonary fibrosis (IPF) (n = 21). Serum levels of these proteins were determined by ELISA. E-selectin, ICAM-1, and ET-1 serum levels were increased in RA-ILD+ and IPF patients in comparison to RA-ILD? patients. Additionally, SSc-ILD+ and IPF patients exhibited higher ICAM-1 levels than those with SSc-ILD?. The ability of E-selectin, ICAM-1, and ET-1 to discriminate RA-ILD+ from RA-ILD? patients, and ICAM-1 to distinguish SSc-ILD+ from SSc-ILD? patients was confirmed using ROC curve analysis. Furthermore, elevated levels of ET-1 and E-selectin correlated with lung function decline in RA-ILD+ and SSc-ILD+ patients, respectively. In conclusion, our findings support the relevant role of E-selectin, ICAM-1, and ET-1 in RA-ILD+ patients as well as of ICAM-1 in SSc-ILD+ patients, constituting potential screening blood biomarkers of ILD in AD. Moreover, this study suggests ET-1 and E-selectin as possible indicators of worsening lung function in RA-ILD+ and SSc-ILD+ patients, respectively.MSM-G is financed by funds of PI21/00042 from ISCIII, co-funded by the ESF; RL-M is a recipient of a Miguel Servet type II Program fellowship from ISCIII, co-funded by the ESF, In-vesting in your future' (CPII21/00004).2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/64ec7b2be13d1f2d6d3b6a9ahttp://hdl.handle.net/20.500.11940/21374reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/213742026-06-12T08:40:47Z
dc.title.none.fl_str_mv E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases
title E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases
spellingShingle E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases
Pulito-Cueto, V.
Humans
Intercellular Adhesion Molecule-1
E-Selectin
Lung Diseases, Interstitial
Idiopathic Pulmonary Fibrosis
Autoimmune Diseases
Arthritis, Rheumatoid
Biomarkers
Scleroderma, Systemic
Lung
AS Santiago
CHUS
title_short E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases
title_full E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases
title_fullStr E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases
title_full_unstemmed E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases
title_sort E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases
dc.creator.none.fl_str_mv Pulito-Cueto, V.
Remuzgo-Martínez, S.
Genre, F.
Atienza-Mateo, B.
Mora-Cuesta, V.M.
Iturbe-Fernández, D.
Lera-Gómez, L.
Mora-Gil, M.S.
Portilla, V.
Corrales, A.
Blanco, R.
Cifrián, J.M.
González-Gay Mantecón, Miguel Ángel
López-Mejías, R.
author Pulito-Cueto, V.
author_facet Pulito-Cueto, V.
Remuzgo-Martínez, S.
Genre, F.
Atienza-Mateo, B.
Mora-Cuesta, V.M.
Iturbe-Fernández, D.
Lera-Gómez, L.
Mora-Gil, M.S.
Portilla, V.
Corrales, A.
Blanco, R.
Cifrián, J.M.
González-Gay Mantecón, Miguel Ángel
López-Mejías, R.
author_role author
author2 Remuzgo-Martínez, S.
Genre, F.
Atienza-Mateo, B.
Mora-Cuesta, V.M.
Iturbe-Fernández, D.
Lera-Gómez, L.
Mora-Gil, M.S.
Portilla, V.
Corrales, A.
Blanco, R.
Cifrián, J.M.
González-Gay Mantecón, Miguel Ángel
López-Mejías, R.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Humans
Intercellular Adhesion Molecule-1
E-Selectin
Lung Diseases, Interstitial
Idiopathic Pulmonary Fibrosis
Autoimmune Diseases
Arthritis, Rheumatoid
Biomarkers
Scleroderma, Systemic
Lung
AS Santiago
CHUS
topic Humans
Intercellular Adhesion Molecule-1
E-Selectin
Lung Diseases, Interstitial
Idiopathic Pulmonary Fibrosis
Autoimmune Diseases
Arthritis, Rheumatoid
Biomarkers
Scleroderma, Systemic
Lung
AS Santiago
CHUS
description Interstitial lung disease (ILD) constitutes the most critical comorbidity in autoimmune diseases (ADs) and its early diagnosis remains a challenge for clinicians. Accordingly, we evaluated whether E-selectin, ICAM-1, and ET-1, key molecules in endothelial damage, could be useful biomarkers for the detection of AD-ILD+. We recruited patients with rheumatoid arthritis (RA)-ILD+ (n = 21) and systemic sclerosis (SSc)-ILD+ (n = 21). We included comparison groups of patients: RA-ILD? (n = 25), SSc-ILD? (n = 20), and idiopathic pulmonary fibrosis (IPF) (n = 21). Serum levels of these proteins were determined by ELISA. E-selectin, ICAM-1, and ET-1 serum levels were increased in RA-ILD+ and IPF patients in comparison to RA-ILD? patients. Additionally, SSc-ILD+ and IPF patients exhibited higher ICAM-1 levels than those with SSc-ILD?. The ability of E-selectin, ICAM-1, and ET-1 to discriminate RA-ILD+ from RA-ILD? patients, and ICAM-1 to distinguish SSc-ILD+ from SSc-ILD? patients was confirmed using ROC curve analysis. Furthermore, elevated levels of ET-1 and E-selectin correlated with lung function decline in RA-ILD+ and SSc-ILD+ patients, respectively. In conclusion, our findings support the relevant role of E-selectin, ICAM-1, and ET-1 in RA-ILD+ patients as well as of ICAM-1 in SSc-ILD+ patients, constituting potential screening blood biomarkers of ILD in AD. Moreover, this study suggests ET-1 and E-selectin as possible indicators of worsening lung function in RA-ILD+ and SSc-ILD+ patients, respectively.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/64ec7b2be13d1f2d6d3b6a9a
http://hdl.handle.net/20.500.11940/21374
url https://portalcientifico.sergas.gal//documentos/64ec7b2be13d1f2d6d3b6a9a
http://hdl.handle.net/20.500.11940/21374
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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