MAMI: a birth cohort focused on maternal-infant microbiota during early life
BackgroundEarly microbial colonization is a relevant aspect in human health. Altered microbial colonization patterns have been linked to an increased risk of non-communicable diseases (NCDs). Advances in understanding host-microbe interactions highlight the pivotal role of maternal microbiota on inf...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p6915 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/6915 |
| Access Level: | acceso abierto |
| Palabra clave: | Cohort study Microbiota Diet Lactation Neonates Meconium Early nutrition Growth Breast milk Antibiotics Birth |
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MAMI: a birth cohort focused on maternal-infant microbiota during early lifeGarcia-Mantrana, IAlcantara, CSelma-Royo, MBoix-Amoros, ADzidic, MGimeno-Alcaniz, JUbeda-Sansano, ISorribes-Monrabal, IEscuriet, RGil-Raga, FParra-Llorca, AMartinez-Costa, CCollado, MCBauerl, CVilloldo, EZafra, COlivares, LPerez-Martinez, GMira, AFerrer, MDSantamaria, JMAhicart, AVento, MGormaz, MCernada, MBertua-Rios, BPadilla, BCrehua-Gaudiza, EPereto-Moll, AGarcia, ARRico, MDSMartinez, NBSegarra, IRSoriano, JLTBlesa-Baviera, LCVidal, APHornos, LMdel Moral, TGCano, PDFerrer, MFIDelgado, CAtero, AMAMI TeamCohort studyMicrobiotaDietLactationNeonatesMeconiumEarly nutritionGrowthBreast milkAntibioticsBirthBackgroundEarly microbial colonization is a relevant aspect in human health. Altered microbial colonization patterns have been linked to an increased risk of non-communicable diseases (NCDs). Advances in understanding host-microbe interactions highlight the pivotal role of maternal microbiota on infant health programming. This birth cohort is aimed to characterize the maternal microbes transferred to neonates during the first 1000days of life, as well as to identify the potential host and environmental factors, such as gestational age, mode of delivery, maternal/infant diet, and exposure to antibiotics, which affect early microbial colonization.MethodsMAMI is a prospective mother-infant birth cohort in the Spanish-Mediterranean area. Mothers were enrolled at the end of pregnancy and families were follow-up during the first years of life. Maternal-infant biological samples were collected at several time points from birth to 24months of life. Clinical and anthropometric characteristics and dietary information is available. Specific qPCR and 16S rRNA gene sequencing as well as short chain fatty acid (SCFAs) profile would be obtained. Multivariable models will be used to identy associations between microbiota and clinical and anthropometric data controlling for confounders.MAMI would contribute to a better understanding of the interaction between diet, microbiota and host response in early life health programming, enabling new applications in the field of personalized nutrition and medicine.Trial registrationThe study is registered on the ClinicalTrial.gov platform NCT03552939. (June 12, 2018).BMC2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/6915BMC PediatricsISSN: 14712431reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p69152026-06-11T12:45:17Z |
| dc.title.none.fl_str_mv |
MAMI: a birth cohort focused on maternal-infant microbiota during early life |
| title |
MAMI: a birth cohort focused on maternal-infant microbiota during early life |
| spellingShingle |
MAMI: a birth cohort focused on maternal-infant microbiota during early life Garcia-Mantrana, I Cohort study Microbiota Diet Lactation Neonates Meconium Early nutrition Growth Breast milk Antibiotics Birth |
| title_short |
MAMI: a birth cohort focused on maternal-infant microbiota during early life |
| title_full |
MAMI: a birth cohort focused on maternal-infant microbiota during early life |
| title_fullStr |
MAMI: a birth cohort focused on maternal-infant microbiota during early life |
| title_full_unstemmed |
MAMI: a birth cohort focused on maternal-infant microbiota during early life |
| title_sort |
MAMI: a birth cohort focused on maternal-infant microbiota during early life |
| dc.creator.none.fl_str_mv |
Garcia-Mantrana, I Alcantara, C Selma-Royo, M Boix-Amoros, A Dzidic, M Gimeno-Alcaniz, J Ubeda-Sansano, I Sorribes-Monrabal, I Escuriet, R Gil-Raga, F Parra-Llorca, A Martinez-Costa, C Collado, MC Bauerl, C Villoldo, E Zafra, C Olivares, L Perez-Martinez, G Mira, A Ferrer, MD Santamaria, JM Ahicart, A Vento, M Gormaz, M Cernada, M Bertua-Rios, B Padilla, B Crehua-Gaudiza, E Pereto-Moll, A Garcia, AR Rico, MDS Martinez, NB Segarra, IR Soriano, JLT Blesa-Baviera, LC Vidal, AP Hornos, LM del Moral, TG Cano, PD Ferrer, MFI Delgado, C Atero, A MAMI Team |
| author |
Garcia-Mantrana, I |
| author_facet |
Garcia-Mantrana, I Alcantara, C Selma-Royo, M Boix-Amoros, A Dzidic, M Gimeno-Alcaniz, J Ubeda-Sansano, I Sorribes-Monrabal, I Escuriet, R Gil-Raga, F Parra-Llorca, A Martinez-Costa, C Collado, MC Bauerl, C Villoldo, E Zafra, C Olivares, L Perez-Martinez, G Mira, A Ferrer, MD Santamaria, JM Ahicart, A Vento, M Gormaz, M Cernada, M Bertua-Rios, B Padilla, B Crehua-Gaudiza, E Pereto-Moll, A Garcia, AR Rico, MDS Martinez, NB Segarra, IR Soriano, JLT Blesa-Baviera, LC Vidal, AP Hornos, LM del Moral, TG Cano, PD Ferrer, MFI Delgado, C Atero, A MAMI Team |
| author_role |
author |
| author2 |
Alcantara, C Selma-Royo, M Boix-Amoros, A Dzidic, M Gimeno-Alcaniz, J Ubeda-Sansano, I Sorribes-Monrabal, I Escuriet, R Gil-Raga, F Parra-Llorca, A Martinez-Costa, C Collado, MC Bauerl, C Villoldo, E Zafra, C Olivares, L Perez-Martinez, G Mira, A Ferrer, MD Santamaria, JM Ahicart, A Vento, M Gormaz, M Cernada, M Bertua-Rios, B Padilla, B Crehua-Gaudiza, E Pereto-Moll, A Garcia, AR Rico, MDS Martinez, NB Segarra, IR Soriano, JLT Blesa-Baviera, LC Vidal, AP Hornos, LM del Moral, TG Cano, PD Ferrer, MFI Delgado, C Atero, A MAMI Team |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cohort study Microbiota Diet Lactation Neonates Meconium Early nutrition Growth Breast milk Antibiotics Birth |
| topic |
Cohort study Microbiota Diet Lactation Neonates Meconium Early nutrition Growth Breast milk Antibiotics Birth |
| description |
BackgroundEarly microbial colonization is a relevant aspect in human health. Altered microbial colonization patterns have been linked to an increased risk of non-communicable diseases (NCDs). Advances in understanding host-microbe interactions highlight the pivotal role of maternal microbiota on infant health programming. This birth cohort is aimed to characterize the maternal microbes transferred to neonates during the first 1000days of life, as well as to identify the potential host and environmental factors, such as gestational age, mode of delivery, maternal/infant diet, and exposure to antibiotics, which affect early microbial colonization.MethodsMAMI is a prospective mother-infant birth cohort in the Spanish-Mediterranean area. Mothers were enrolled at the end of pregnancy and families were follow-up during the first years of life. Maternal-infant biological samples were collected at several time points from birth to 24months of life. Clinical and anthropometric characteristics and dietary information is available. Specific qPCR and 16S rRNA gene sequencing as well as short chain fatty acid (SCFAs) profile would be obtained. Multivariable models will be used to identy associations between microbiota and clinical and anthropometric data controlling for confounders.MAMI would contribute to a better understanding of the interaction between diet, microbiota and host response in early life health programming, enabling new applications in the field of personalized nutrition and medicine.Trial registrationThe study is registered on the ClinicalTrial.gov platform NCT03552939. (June 12, 2018). |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://fisabio.portalinvestigacion.com/publicaciones/6915 |
| url |
https://fisabio.portalinvestigacion.com/publicaciones/6915 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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BMC |
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BMC |
| dc.source.none.fl_str_mv |
BMC Pediatrics ISSN: 14712431 reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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1869404384478101504 |
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15.811543 |