Autophagy deficiency by Atg4B loss leads to metabolomic alterations in mice

This article belongs to the Special Issue Autophagy, Aging and Metabolism.

Detalles Bibliográficos
Autores: Martínez-García, Gemma G., Pérez, Raúl F., Fernández, Álvaro, Durand, Sylvère, Kroemer, Guido, Mariño, Guillermo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/259038
Acceso en línea:http://hdl.handle.net/10261/259038
Access Level:acceso abierto
Palabra clave:Autophagy
Autophagin
Metabolome
GABARAP
ATG4
LC3
Aging
ATG8
Autophagosome
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oai_identifier_str oai:digital.csic.es:10261/259038
network_acronym_str ES
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repository_id_str
spelling Autophagy deficiency by Atg4B loss leads to metabolomic alterations in miceMartínez-García, Gemma G.Pérez, Raúl F.Fernández, ÁlvaroDurand, SylvèreKroemer, GuidoMariño, GuillermoAutophagyAutophaginMetabolomeGABARAPATG4LC3AgingATG8AutophagosomeThis article belongs to the Special Issue Autophagy, Aging and Metabolism.Autophagy is an essential protective mechanism that allows mammalian cells to cope with a variety of stressors and contributes to maintaining cellular and tissue homeostasis. Due to these crucial roles and also to the fact that autophagy malfunction has been described in a wide range of pathologies, an increasing number of in vivo studies involving animal models targeting autophagy genes have been developed. In mammals, total autophagy inactivation is lethal, and constitutive knockout models lacking effectors of this route are not viable, which has hindered so far the analysis of the consequences of a systemic autophagy decline. Here, we take advantage of atg4b−/− mice, an autophagy-deficient model with only partial disruption of the process, to assess the effects of systemic reduction of autophagy on the metabolome. We describe for the first time the metabolic footprint of systemic autophagy decline, showing that impaired autophagy results in highly tissue-dependent alterations that are more accentuated in the skeletal muscle and plasma. These changes, which include changes in the levels of amino-acids, lipids, or nucleosides, sometimes resemble those that are frequently described in conditions like aging, obesity, or cardiac damage. We also discuss different hypotheses on how impaired autophagy may affect the metabolism of several tissues in mammals.This work was supported by grants from Ministerio de Economía y Competitividad (Spain) (BFU2015-68539-R) and Principality of Asturias Government (IDI/2018/000159). G.G.M.-G. is supported by a FPI fellowship from Ministerio de Economía y Competitividad (Spain) (BES-2016-076977). R.F.P. is supported by the Severo Ochoa program (BP17-114).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Principado de AsturiasConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/259038reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//BFU2015-68539-Rhttps://doi.org/10.3390/metabo11080481Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2590382026-05-22T06:33:51Z
dc.title.none.fl_str_mv Autophagy deficiency by Atg4B loss leads to metabolomic alterations in mice
title Autophagy deficiency by Atg4B loss leads to metabolomic alterations in mice
spellingShingle Autophagy deficiency by Atg4B loss leads to metabolomic alterations in mice
Martínez-García, Gemma G.
Autophagy
Autophagin
Metabolome
GABARAP
ATG4
LC3
Aging
ATG8
Autophagosome
title_short Autophagy deficiency by Atg4B loss leads to metabolomic alterations in mice
title_full Autophagy deficiency by Atg4B loss leads to metabolomic alterations in mice
title_fullStr Autophagy deficiency by Atg4B loss leads to metabolomic alterations in mice
title_full_unstemmed Autophagy deficiency by Atg4B loss leads to metabolomic alterations in mice
title_sort Autophagy deficiency by Atg4B loss leads to metabolomic alterations in mice
dc.creator.none.fl_str_mv Martínez-García, Gemma G.
Pérez, Raúl F.
Fernández, Álvaro
Durand, Sylvère
Kroemer, Guido
Mariño, Guillermo
author Martínez-García, Gemma G.
author_facet Martínez-García, Gemma G.
Pérez, Raúl F.
Fernández, Álvaro
Durand, Sylvère
Kroemer, Guido
Mariño, Guillermo
author_role author
author2 Pérez, Raúl F.
Fernández, Álvaro
Durand, Sylvère
Kroemer, Guido
Mariño, Guillermo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Principado de Asturias
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Autophagy
Autophagin
Metabolome
GABARAP
ATG4
LC3
Aging
ATG8
Autophagosome
topic Autophagy
Autophagin
Metabolome
GABARAP
ATG4
LC3
Aging
ATG8
Autophagosome
description This article belongs to the Special Issue Autophagy, Aging and Metabolism.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/259038
url http://hdl.handle.net/10261/259038
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//BFU2015-68539-R
https://doi.org/10.3390/metabo11080481
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.808905

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