Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study

Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological p...

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Autores: Gómez-Acebo, Inés, Dierssen-Sotos, Trinidad, Palazuelos-Calderón, Camilo, Perez-Gomez, Beatriz, Amiano, Pilar, Guevara, Marcela, Molina, Antonio J, Domingo, Laia, Fernández-Ortiz, María, Moreno, Victor, Alguacil, Juan, Fernández-Tardón, Guillermo, Ibáñez, Josefa, Marcos-Gragera, Rafael, Diaz-Santos, Marian, Alonso, María Henar, Alonso-Molero, Jéssica, Castaño-Vinyals, Gemma, Palomo, Andrés García, Ardanaz, Eva, Molinuevo, Amaia, Aragones, Nuria, Kogevinas, Manolis, Pollan-Santamaria, Marina, Llorca, Javier
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/14109
Acceso en línea:http://hdl.handle.net/20.500.12105/14109
Access Level:acceso abierto
Palabra clave:Survivorship
Adult
Aged
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spelling Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain studyGómez-Acebo, InésDierssen-Sotos, TrinidadPalazuelos-Calderón, CamiloPerez-Gomez, BeatrizAmiano, PilarGuevara, MarcelaMolina, Antonio JDomingo, LaiaFernández-Ortiz, MaríaMoreno, VictorAlguacil, JuanFernández-Tardón, GuillermoIbáñez, JosefaMarcos-Gragera, RafaelDiaz-Santos, MarianAlonso, María HenarAlonso-Molero, JéssicaCastaño-Vinyals, GemmaPalomo, Andrés GarcíaArdanaz, EvaMolinuevo, AmaiaAragones, NuriaKogevinas, ManolisPollan-Santamaria, MarinaLlorca, JavierSurvivorshipAdultAgedPurpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased.SpringerUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Instituto de Salud Carlos IIIGovernment of SpainFundación Marqués de ValdecillaJunta de Castilla y León (España)Regional Government of Andalusia (España)Generalitat Valenciana (España)Fundación La CaixaBasque Government (España)Gobierno de la Región de Murcia (España)Unión Europea. Comisión EuropeaAsociación Española Contra el CáncerGovernment of Catalonia (España)Fundación Caja de Ahorros de AsturiasUniversity of Valencia (España)Societat Catalana de DigestologiaUnión Europea. European Cooperation in Science and Technology (COST)20222022-04-1920202020-06-0120202020-06-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/14109reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Seventh Framework Programme FOOD-CT-2006–036224-HIWATEopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/141092026-06-12T12:43:37Z
dc.title.none.fl_str_mv Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
spellingShingle Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
Gómez-Acebo, Inés
Survivorship
Adult
Aged
title_short Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_full Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_fullStr Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_full_unstemmed Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_sort Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
dc.creator.none.fl_str_mv Gómez-Acebo, Inés
Dierssen-Sotos, Trinidad
Palazuelos-Calderón, Camilo
Perez-Gomez, Beatriz
Amiano, Pilar
Guevara, Marcela
Molina, Antonio J
Domingo, Laia
Fernández-Ortiz, María
Moreno, Victor
Alguacil, Juan
Fernández-Tardón, Guillermo
Ibáñez, Josefa
Marcos-Gragera, Rafael
Diaz-Santos, Marian
Alonso, María Henar
Alonso-Molero, Jéssica
Castaño-Vinyals, Gemma
Palomo, Andrés García
Ardanaz, Eva
Molinuevo, Amaia
Aragones, Nuria
Kogevinas, Manolis
Pollan-Santamaria, Marina
Llorca, Javier
author Gómez-Acebo, Inés
author_facet Gómez-Acebo, Inés
Dierssen-Sotos, Trinidad
Palazuelos-Calderón, Camilo
Perez-Gomez, Beatriz
Amiano, Pilar
Guevara, Marcela
Molina, Antonio J
Domingo, Laia
Fernández-Ortiz, María
Moreno, Victor
Alguacil, Juan
Fernández-Tardón, Guillermo
Ibáñez, Josefa
Marcos-Gragera, Rafael
Diaz-Santos, Marian
Alonso, María Henar
Alonso-Molero, Jéssica
Castaño-Vinyals, Gemma
Palomo, Andrés García
Ardanaz, Eva
Molinuevo, Amaia
Aragones, Nuria
Kogevinas, Manolis
Pollan-Santamaria, Marina
Llorca, Javier
author_role author
author2 Dierssen-Sotos, Trinidad
Palazuelos-Calderón, Camilo
Perez-Gomez, Beatriz
Amiano, Pilar
Guevara, Marcela
Molina, Antonio J
Domingo, Laia
Fernández-Ortiz, María
Moreno, Victor
Alguacil, Juan
Fernández-Tardón, Guillermo
Ibáñez, Josefa
Marcos-Gragera, Rafael
Diaz-Santos, Marian
Alonso, María Henar
Alonso-Molero, Jéssica
Castaño-Vinyals, Gemma
Palomo, Andrés García
Ardanaz, Eva
Molinuevo, Amaia
Aragones, Nuria
Kogevinas, Manolis
Pollan-Santamaria, Marina
Llorca, Javier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Instituto de Salud Carlos III
Government of Spain
Fundación Marqués de Valdecilla
Junta de Castilla y León (España)
Regional Government of Andalusia (España)
Generalitat Valenciana (España)
Fundación La Caixa
Basque Government (España)
Gobierno de la Región de Murcia (España)
Unión Europea. Comisión Europea
Asociación Española Contra el Cáncer
Government of Catalonia (España)
Fundación Caja de Ahorros de Asturias
University of Valencia (España)
Societat Catalana de Digestologia
Unión Europea. European Cooperation in Science and Technology (COST)
dc.subject.none.fl_str_mv Survivorship
Adult
Aged
topic Survivorship
Adult
Aged
description Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-06-01
2020
2020-06-01
2022
2022-04-19
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/14109
url http://hdl.handle.net/20.500.12105/14109
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Seventh Framework Programme FOOD-CT-2006–036224-HIWATE
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404362421305344
score 15.81155

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