The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A

Background: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently unknown, but may involve Semaphor...

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Autores: Lobna, Matanis, Nasren, Eiza, Adi, Sabag, Jacob, Bejar, Giménez-Arnau, Ana M..|||0000-0001-5434-7753, Marcus, Maurer, Zahava, Vadasz
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:238532
Acesso em linha:https://ddd.uab.cat/record/238532
https://dx.doi.org/urn:doi:10.3390/biom11030373
Access Level:acceso abierto
Palavra-chave:Chronic spontaneous urticaria
T cells
Mast cells
Semaphorin5A
IL-17
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spelling The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5ALobna, MatanisNasren, EizaAdi, SabagJacob, BejarGiménez-Arnau, Ana M..|||0000-0001-5434-7753Marcus, MaurerZahava, VadaszChronic spontaneous urticariaT cellsMast cellsSemaphorin5AIL-17Background: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently unknown, but may involve Semaphorin5A (Sema5A). Objective: To explore the expression, role, and effects of Sema5A in CSU and its link to IL-17A. Material and Methods: We investigated patients with CSU and healthy controls for skin expression of expressing peripheral T cells. Results: Sema5A was highly expressed in the skin of CSU patients as compared to healthy control skin. Both CD4+ T cells and mast cells in CSU skin expressed Sema5A, and many of them expressed both Sema5A and IL-17A. Patients with CSU had significantly higher rates of IL-17A-expressing CD4+ T cells as compared to healthy controls. Incubation with Sema5A increased the rates of IL-17A-expressing CD4+ T cells in healthy controls to CSU levels. Conclusion: Sema5A may drive the expression and effects of IL-17A in CSU. Further studies in larger cohorts are needed to confirm the role of Sema5A in the pathogenesis of CSU and to explore its potential as a therapeutic target.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/238532https://dx.doi.org/urn:doi:10.3390/biom11030373reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2385322026-06-06T12:50:31Z
dc.title.none.fl_str_mv The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A
title The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A
spellingShingle The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A
Lobna, Matanis
Chronic spontaneous urticaria
T cells
Mast cells
Semaphorin5A
IL-17
title_short The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A
title_full The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A
title_fullStr The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A
title_full_unstemmed The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A
title_sort The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A
dc.creator.none.fl_str_mv Lobna, Matanis
Nasren, Eiza
Adi, Sabag
Jacob, Bejar
Giménez-Arnau, Ana M..|||0000-0001-5434-7753
Marcus, Maurer
Zahava, Vadasz
author Lobna, Matanis
author_facet Lobna, Matanis
Nasren, Eiza
Adi, Sabag
Jacob, Bejar
Giménez-Arnau, Ana M..|||0000-0001-5434-7753
Marcus, Maurer
Zahava, Vadasz
author_role author
author2 Nasren, Eiza
Adi, Sabag
Jacob, Bejar
Giménez-Arnau, Ana M..|||0000-0001-5434-7753
Marcus, Maurer
Zahava, Vadasz
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Chronic spontaneous urticaria
T cells
Mast cells
Semaphorin5A
IL-17
topic Chronic spontaneous urticaria
T cells
Mast cells
Semaphorin5A
IL-17
description Background: Patients with chronic spontaneous urticaria (CSU), an autoimmune disorder, show increased skin expression of IL-17A and can benefit from treatment with the anti-IL-17A biologic secukinumab. The mechanisms that drive IL-17A expression in CSU are currently unknown, but may involve Semaphorin5A (Sema5A). Objective: To explore the expression, role, and effects of Sema5A in CSU and its link to IL-17A. Material and Methods: We investigated patients with CSU and healthy controls for skin expression of expressing peripheral T cells. Results: Sema5A was highly expressed in the skin of CSU patients as compared to healthy control skin. Both CD4+ T cells and mast cells in CSU skin expressed Sema5A, and many of them expressed both Sema5A and IL-17A. Patients with CSU had significantly higher rates of IL-17A-expressing CD4+ T cells as compared to healthy controls. Incubation with Sema5A increased the rates of IL-17A-expressing CD4+ T cells in healthy controls to CSU levels. Conclusion: Sema5A may drive the expression and effects of IL-17A in CSU. Further studies in larger cohorts are needed to confirm the role of Sema5A in the pathogenesis of CSU and to explore its potential as a therapeutic target.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/238532
https://dx.doi.org/urn:doi:10.3390/biom11030373
url https://ddd.uab.cat/record/238532
https://dx.doi.org/urn:doi:10.3390/biom11030373
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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