Multivalvular Endocarditis: A Rare Condition with Poor Prognosis.
Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods. We used a retrospective analysis of the Spanish IE Registry (2008−2020). Re...
| Autores: | , , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/202163 |
| Acesso em linha: | https://hdl.handle.net/2445/202163 |
| Access Level: | acceso abierto |
| Palavra-chave: | Endocarditis Pronòstic mèdic Vàlvules cardíaques Mortalitat Prognosis Heart valves Mortality |
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Multivalvular Endocarditis: A Rare Condition with Poor Prognosis.Álvarez Zaballos, SaraGonzález-Ramallo, VíctorQuintana, EduardMuñoz, PatriciaDe la Villa, SofíaFariñas, María CarmenArnáiz de las Revillas, FranciscoAlarcón, Aristides deRodríguez-Esteban, M. ÁngelesMiró Meda, José M. (José María), 1956-Goenaga Sánchez, Miguel ÁngelGoikoetxea Agirre, Ane JosuneGarcía Vázquez, ElisaBoix Palop, LucíaMartínez-Sellés, ManueGrupo de Apoyo al Manejo de la Endocarditis infeccEndocarditisPronòstic mèdicVàlvules cardíaquesMortalitatEndocarditisPrognosisHeart valvesMortalityBackground. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods. We used a retrospective analysis of the Spanish IE Registry (2008−2020). Results. From 4064 definite cases of valvular IE, 577 (14.2%) had MIE. In patients with MIE, the most common locations were mitral (552, 95.7%) and aortic (550, 95.3%), with mitral-aortic involvement present in 507 patients (87.9%). The most common etiologies were S. viridans (192, 33.3%) and S. aureus (113, 19.6%). MIE involved only native valves in 450 patients (78.0%). Compared with patients with SIE, patients with MIE had a similar age (69 vs. 67 years, respectively, p = 0.27) and similar baseline characteristics, but were more frequently men (67.1% vs. 72.9%, p = 0.005) and had a higher incidence of intracardiac complications (36.2% vs. 50.4%, p < 0.001), heart failure (42.7% vs. 52.9%, p < 0.001), surgical indication (67.7 vs. 85.1%, p < 0.001), surgery (46.3% vs. 56.3%), and in-hospital mortality (26.9% vs. 34.3%, p < 0.001). MIE was an independent predictor of in-hospital mortality (odds ratio (OR) 1.3, 95% confidence interval (CI) 1.1−1.7, p = 0.004) but did not have an independent association with 1-year mortality (OR 1.1, 95% CI 0.9−1.4, p = 0.43). Conclusions. About one-seventh of the valvular IE patients had MIE, mainly due to mitral-aortic involvement. MIE is associated with a poor in-hospital prognosis. An early diagnosis and treatment of IE might avoid its spread to a second valve.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/202163Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jcm11164736Journal of Clinical Medicine, 2022, vol. 11, num. 16, p. 4736https://doi.org/10.3390/jcm11164736cc-by (c) Álvarez Zaballos, Sara et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2021632026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. |
| title |
Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. |
| spellingShingle |
Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. Álvarez Zaballos, Sara Endocarditis Pronòstic mèdic Vàlvules cardíaques Mortalitat Endocarditis Prognosis Heart valves Mortality |
| title_short |
Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. |
| title_full |
Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. |
| title_fullStr |
Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. |
| title_full_unstemmed |
Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. |
| title_sort |
Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. |
| dc.creator.none.fl_str_mv |
Álvarez Zaballos, Sara González-Ramallo, Víctor Quintana, Eduard Muñoz, Patricia De la Villa, Sofía Fariñas, María Carmen Arnáiz de las Revillas, Francisco Alarcón, Aristides de Rodríguez-Esteban, M. Ángeles Miró Meda, José M. (José María), 1956- Goenaga Sánchez, Miguel Ángel Goikoetxea Agirre, Ane Josune García Vázquez, Elisa Boix Palop, Lucía Martínez-Sellés, Manue Grupo de Apoyo al Manejo de la Endocarditis infecc |
| author |
Álvarez Zaballos, Sara |
| author_facet |
Álvarez Zaballos, Sara González-Ramallo, Víctor Quintana, Eduard Muñoz, Patricia De la Villa, Sofía Fariñas, María Carmen Arnáiz de las Revillas, Francisco Alarcón, Aristides de Rodríguez-Esteban, M. Ángeles Miró Meda, José M. (José María), 1956- Goenaga Sánchez, Miguel Ángel Goikoetxea Agirre, Ane Josune García Vázquez, Elisa Boix Palop, Lucía Martínez-Sellés, Manue Grupo de Apoyo al Manejo de la Endocarditis infecc |
| author_role |
author |
| author2 |
González-Ramallo, Víctor Quintana, Eduard Muñoz, Patricia De la Villa, Sofía Fariñas, María Carmen Arnáiz de las Revillas, Francisco Alarcón, Aristides de Rodríguez-Esteban, M. Ángeles Miró Meda, José M. (José María), 1956- Goenaga Sánchez, Miguel Ángel Goikoetxea Agirre, Ane Josune García Vázquez, Elisa Boix Palop, Lucía Martínez-Sellés, Manue Grupo de Apoyo al Manejo de la Endocarditis infecc |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Endocarditis Pronòstic mèdic Vàlvules cardíaques Mortalitat Endocarditis Prognosis Heart valves Mortality |
| topic |
Endocarditis Pronòstic mèdic Vàlvules cardíaques Mortalitat Endocarditis Prognosis Heart valves Mortality |
| description |
Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective endocarditis (MIE) and compare them to single-valve IE (SIE). Methods. We used a retrospective analysis of the Spanish IE Registry (2008−2020). Results. From 4064 definite cases of valvular IE, 577 (14.2%) had MIE. In patients with MIE, the most common locations were mitral (552, 95.7%) and aortic (550, 95.3%), with mitral-aortic involvement present in 507 patients (87.9%). The most common etiologies were S. viridans (192, 33.3%) and S. aureus (113, 19.6%). MIE involved only native valves in 450 patients (78.0%). Compared with patients with SIE, patients with MIE had a similar age (69 vs. 67 years, respectively, p = 0.27) and similar baseline characteristics, but were more frequently men (67.1% vs. 72.9%, p = 0.005) and had a higher incidence of intracardiac complications (36.2% vs. 50.4%, p < 0.001), heart failure (42.7% vs. 52.9%, p < 0.001), surgical indication (67.7 vs. 85.1%, p < 0.001), surgery (46.3% vs. 56.3%), and in-hospital mortality (26.9% vs. 34.3%, p < 0.001). MIE was an independent predictor of in-hospital mortality (odds ratio (OR) 1.3, 95% confidence interval (CI) 1.1−1.7, p = 0.004) but did not have an independent association with 1-year mortality (OR 1.1, 95% CI 0.9−1.4, p = 0.43). Conclusions. About one-seventh of the valvular IE patients had MIE, mainly due to mitral-aortic involvement. MIE is associated with a poor in-hospital prognosis. An early diagnosis and treatment of IE might avoid its spread to a second valve. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/202163 |
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https://hdl.handle.net/2445/202163 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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Reproducció del document publicat a: https://doi.org/10.3390/jcm11164736 Journal of Clinical Medicine, 2022, vol. 11, num. 16, p. 4736 https://doi.org/10.3390/jcm11164736 |
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cc-by (c) Álvarez Zaballos, Sara et al., 2022 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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cc-by (c) Álvarez Zaballos, Sara et al., 2022 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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Articles publicats en revistes (Medicina) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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