Impact of ovarian endometrioma and surgery on reproductive outcomes: a single-center Spanish cohort study

Anti-Müllerian hormone (AMH) and antral follicular count (AFC) decrease in women with ovarian endometrioma (OMA) and in vitro fertilization (IVF). In addition, these parameters drop even further when women with OMA undergo surgery. In this study, the primary aim was to compare the reproductive varia...

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Autores: Hernández Gutiérrez, María Alicia, Sanz, Angela, Spagnolo, Emanuela, Lopez, Ana, Martínez Jorge, Paloma, Iniesta, Silvia, Rodríguez, Elena, Fernández Prada, Sara, Ramiro Cortijo, David
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/708465
Acceso en línea:http://hdl.handle.net/10486/708465
https://dx.doi.org/10.3390/biomedicines11030844
Access Level:acceso abierto
Palabra clave:endometriosis
in vitro fertilization
surgically treatment
ovarian endometrioma
ovarian reserve
Medicina
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spelling Impact of ovarian endometrioma and surgery on reproductive outcomes: a single-center Spanish cohort studyHernández Gutiérrez, María AliciaSanz, AngelaSpagnolo, EmanuelaLopez, AnaMartínez Jorge, PalomaIniesta, SilviaRodríguez, ElenaFernández Prada, SaraRamiro Cortijo, Davidendometriosisin vitro fertilizationsurgically treatmentovarian endometriomaovarian reserveMedicinaAnti-Müllerian hormone (AMH) and antral follicular count (AFC) decrease in women with ovarian endometrioma (OMA) and in vitro fertilization (IVF). In addition, these parameters drop even further when women with OMA undergo surgery. In this study, the primary aim was to compare the reproductive variables in IVF-treated women with and without endometriosis. The secondary aim was to explore if the reproductive variables were modified by endometrioma surgery. In this retrospective study, 244 women undergoing IVF were enrolled at the Hospital Universitario La Paz (Madrid, Spain). Women were categorized as OMA not surgically treated (OMA; n = 124), OMA with surgery (OMA + S; n = 55), and women with infertility issues not related to OMA (control; n = 65). Demographic and clinical variables, including age, body mass index (BMI), and reproductive (AMH, AFC, number of extracted oocytes, and transferred embryos) and obstetrical data (biochemical pregnancy and fetal heart rate at 6 weeks) were collected. Adjusted logistic regression models were built to evaluate reproductive and pregnancy outcomes. The models showed that women with OMA (with and without surgery) had significantly decreased levels of AMH and AFC and numbers of cycles and C + D embryos. Women with OMA + S had similar rates of pregnancy to women in the control group. However, women with OMA had lower biochemical pregnancy than controls (aOR = 0.08 [0.01; 0.50]; p-value = 0.025). OMA surgery seems to improve pregnancy outcomes, at least until 6 weeks of gestation. However, it is important to counsel the patients about surgery expectations due to the fact that endometrioma itself reduces the quality of oocytesThis research was funded by Health National Project from Instituto de Salud Carlos III (Spain; Ref. PI-20-01368)MDPIDepartamento de Obstetricia y GinecologíaFacultad de Medicina20232023-03-10research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/708465https://dx.doi.org/10.3390/biomedicines11030844reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7084652026-06-23T12:46:27Z
dc.title.none.fl_str_mv Impact of ovarian endometrioma and surgery on reproductive outcomes: a single-center Spanish cohort study
title Impact of ovarian endometrioma and surgery on reproductive outcomes: a single-center Spanish cohort study
spellingShingle Impact of ovarian endometrioma and surgery on reproductive outcomes: a single-center Spanish cohort study
Hernández Gutiérrez, María Alicia
endometriosis
in vitro fertilization
surgically treatment
ovarian endometrioma
ovarian reserve
Medicina
title_short Impact of ovarian endometrioma and surgery on reproductive outcomes: a single-center Spanish cohort study
title_full Impact of ovarian endometrioma and surgery on reproductive outcomes: a single-center Spanish cohort study
title_fullStr Impact of ovarian endometrioma and surgery on reproductive outcomes: a single-center Spanish cohort study
title_full_unstemmed Impact of ovarian endometrioma and surgery on reproductive outcomes: a single-center Spanish cohort study
title_sort Impact of ovarian endometrioma and surgery on reproductive outcomes: a single-center Spanish cohort study
dc.creator.none.fl_str_mv Hernández Gutiérrez, María Alicia
Sanz, Angela
Spagnolo, Emanuela
Lopez, Ana
Martínez Jorge, Paloma
Iniesta, Silvia
Rodríguez, Elena
Fernández Prada, Sara
Ramiro Cortijo, David
author Hernández Gutiérrez, María Alicia
author_facet Hernández Gutiérrez, María Alicia
Sanz, Angela
Spagnolo, Emanuela
Lopez, Ana
Martínez Jorge, Paloma
Iniesta, Silvia
Rodríguez, Elena
Fernández Prada, Sara
Ramiro Cortijo, David
author_role author
author2 Sanz, Angela
Spagnolo, Emanuela
Lopez, Ana
Martínez Jorge, Paloma
Iniesta, Silvia
Rodríguez, Elena
Fernández Prada, Sara
Ramiro Cortijo, David
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Obstetricia y Ginecología
Facultad de Medicina
dc.subject.none.fl_str_mv endometriosis
in vitro fertilization
surgically treatment
ovarian endometrioma
ovarian reserve
Medicina
topic endometriosis
in vitro fertilization
surgically treatment
ovarian endometrioma
ovarian reserve
Medicina
description Anti-Müllerian hormone (AMH) and antral follicular count (AFC) decrease in women with ovarian endometrioma (OMA) and in vitro fertilization (IVF). In addition, these parameters drop even further when women with OMA undergo surgery. In this study, the primary aim was to compare the reproductive variables in IVF-treated women with and without endometriosis. The secondary aim was to explore if the reproductive variables were modified by endometrioma surgery. In this retrospective study, 244 women undergoing IVF were enrolled at the Hospital Universitario La Paz (Madrid, Spain). Women were categorized as OMA not surgically treated (OMA; n = 124), OMA with surgery (OMA + S; n = 55), and women with infertility issues not related to OMA (control; n = 65). Demographic and clinical variables, including age, body mass index (BMI), and reproductive (AMH, AFC, number of extracted oocytes, and transferred embryos) and obstetrical data (biochemical pregnancy and fetal heart rate at 6 weeks) were collected. Adjusted logistic regression models were built to evaluate reproductive and pregnancy outcomes. The models showed that women with OMA (with and without surgery) had significantly decreased levels of AMH and AFC and numbers of cycles and C + D embryos. Women with OMA + S had similar rates of pregnancy to women in the control group. However, women with OMA had lower biochemical pregnancy than controls (aOR = 0.08 [0.01; 0.50]; p-value = 0.025). OMA surgery seems to improve pregnancy outcomes, at least until 6 weeks of gestation. However, it is important to counsel the patients about surgery expectations due to the fact that endometrioma itself reduces the quality of oocytes
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-03-10
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/708465
https://dx.doi.org/10.3390/biomedicines11030844
url http://hdl.handle.net/10486/708465
https://dx.doi.org/10.3390/biomedicines11030844
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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