Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between...

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Detalles Bibliográficos
Autores: Lin, Crystal, Travis, Ruth C., Appleby, Paul N., Tipper, Sarah, Weiderpass, Elisabete, Chang Claude, Jenny, Gram, Inger T., Kaaks, Rudolf, Kiemeney, Lambertus A. L. M., Ljungberg, Börje, Tumino, Rosario, Tjønneland, Anne, Roswall, Nina, Overvad, Kim, Boutron-Ruault, Marie-Christine, Manciniveri, Francesca Romana, Severi, Gianluca, Trichopoulou, Antonia, Masala, Giovanna, Sacerdote, Carlotta, Agnoli, Claudia, Panico, Salvatore, Bueno de Mesquita, H. Bas, Peeters, Petra H. M., Salamanca Fernández, Elena, Chirlaque, María Dolores, Ardanaz, Eva, Dorronsoro, Miren, Menéndez, Virginia, Luján Barroso, Leila, Liedberg, Fredrik, Freisling, Heinz, Gunter, Marc J., Aune, Dagfinn, Cross, Amanda J., Riboli, Elio, Key, Timothy J., Pérez Cornago, Aurora
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/141119
Acceso en línea:https://hdl.handle.net/2445/141119
Access Level:acceso abierto
Palabra clave:Càncer de bufeta
Tumors
Factors de risc en les malalties
Bladder cancer
Risk factors in diseases
Descripción
Sumario:Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66-1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65-1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk.

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