Circulating Metabolites Associated With Alcohol Intake In The European Prospective Investigation Into Cancer And Nutrition Cohort

Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the E...

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Detalles Bibliográficos
Autores: Van Roekel, Eline H., Trijsburg, Laura, Assi, Nada, Carayol, Marion, Achaintre, David, Murphy, Neil, Rinaldi, Sabina, Schmidt, Julie A., Stepien, Magdalena, Kaaks, Rudolf, Kuhn, Tilman, Boeing, Heiner, Iqbal, Khalid, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Peeters, Petra H. M., Bueno de Mesquita, H. Bas, Ardanaz, Eva, Luján Barroso, Leila, Quirós, José Ramón, Huerta Castaño, José María, Molina Portillo, Elena, Dorronsoro, Miren, Tsilidis, Konstantinos K., Riboli, Elio, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Overvad, Kim, Weiderpass, Elisabete, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Trichopoulou, Antonia, Karakatsani, Anna, Kotanidou, Anastasia, Hakänsson, Anders, Malm, Johan, Weijenberg, Matty P., Gunter, Marc J., Jenab, Mazda, Johansson, Mattias, Travis, Ruth C., Scalbert, Augustin, Ferrari, Pietro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/123930
Acceso en línea:https://hdl.handle.net/2445/123930
Access Level:acceso abierto
Palabra clave:Consum d'alcohol
Metabòlits
Càncer
Europa
Europe
Drinking of alcoholic beverages
Metabolites
Cancer
Descripción
Sumario:Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72 metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.

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