Role of group I metabotropic glutamate receptors in spike timing-dependent plasticity

Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, in...

ver descrição completa

Detalhes bibliográficos
Autores: Martínez Gallego, Irene, Rodríguez-Moreno, Antonio, Andrade Talavera, Yuniesky
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universidad Pablo de Olavide (UPO)
Repositorio:RIO. Repositorio Institucional Olavide
Idioma:inglés
OAI Identifier:oai:rio.upo.es:10433/23721
Acesso em linha:https://hdl.handle.net/10433/23721
Access Level:acceso abierto
Palavra-chave:STDP
Glutamate receptor
mGluR
Timing
Synaptic plasticity
id ES_1e6f7fce67dff96d35e5e1b7c5d4fe72
oai_identifier_str oai:rio.upo.es:10433/23721
network_acronym_str ES
network_name_str España
repository_id_str
spelling Role of group I metabotropic glutamate receptors in spike timing-dependent plasticityMartínez Gallego, IreneRodríguez-Moreno, AntonioAndrade Talavera, YunieskySTDPGlutamate receptormGluRTimingSynaptic plasticityMetabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, including excitability and plasticity processes. Particularly, group I mGluRs located at the pre- or postsynaptic compartments are involved in spike timing-dependent plasticity (STDP) at hippocampal and neocortical synapses. Their roles of participating in the underlying mechanisms for detection of activity coincidence in STDP induction are debated, and diverse findings support models involving mGluRs in STDP forms in which NMDARs do not operate as classical postsynaptic coincidence detectors. Here, we briefly review the involvement of group I mGluRs in STDP and their possible role as coincidence detectors.MDPI20252025-04-0320232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10433/23721reponame:RIO. Repositorio Institucional Olavideinstname:Universidad Pablo de Olavide (UPO)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:rio.upo.es:10433/237212026-06-13T12:46:27Z
dc.title.none.fl_str_mv Role of group I metabotropic glutamate receptors in spike timing-dependent plasticity
title Role of group I metabotropic glutamate receptors in spike timing-dependent plasticity
spellingShingle Role of group I metabotropic glutamate receptors in spike timing-dependent plasticity
Martínez Gallego, Irene
STDP
Glutamate receptor
mGluR
Timing
Synaptic plasticity
title_short Role of group I metabotropic glutamate receptors in spike timing-dependent plasticity
title_full Role of group I metabotropic glutamate receptors in spike timing-dependent plasticity
title_fullStr Role of group I metabotropic glutamate receptors in spike timing-dependent plasticity
title_full_unstemmed Role of group I metabotropic glutamate receptors in spike timing-dependent plasticity
title_sort Role of group I metabotropic glutamate receptors in spike timing-dependent plasticity
dc.creator.none.fl_str_mv Martínez Gallego, Irene
Rodríguez-Moreno, Antonio
Andrade Talavera, Yuniesky
author Martínez Gallego, Irene
author_facet Martínez Gallego, Irene
Rodríguez-Moreno, Antonio
Andrade Talavera, Yuniesky
author_role author
author2 Rodríguez-Moreno, Antonio
Andrade Talavera, Yuniesky
author2_role author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv STDP
Glutamate receptor
mGluR
Timing
Synaptic plasticity
topic STDP
Glutamate receptor
mGluR
Timing
Synaptic plasticity
description Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors that exhibit enormous diversity in their expression patterns, sequence homology, pharmacology, biophysical properties and signaling pathways in the brain. In general, mGluRs modulate different traits of neuronal physiology, including excitability and plasticity processes. Particularly, group I mGluRs located at the pre- or postsynaptic compartments are involved in spike timing-dependent plasticity (STDP) at hippocampal and neocortical synapses. Their roles of participating in the underlying mechanisms for detection of activity coincidence in STDP induction are debated, and diverse findings support models involving mGluRs in STDP forms in which NMDARs do not operate as classical postsynaptic coincidence detectors. Here, we briefly review the involvement of group I mGluRs in STDP and their possible role as coincidence detectors.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
2025
2025-04-03
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10433/23721
url https://hdl.handle.net/10433/23721
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:RIO. Repositorio Institucional Olavide
instname:Universidad Pablo de Olavide (UPO)
instname_str Universidad Pablo de Olavide (UPO)
reponame_str RIO. Repositorio Institucional Olavide
collection RIO. Repositorio Institucional Olavide
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404340739899392
score 15,811543

Registos relacionados