Use of muscle ultrasonography in morphofunctional assessment of amyotrophic lateral sclerosis (ALS)

Producción Científica

Bibliographic Details
Authors: López Gómez, Juan José, Izaola Jauregui, Olatz, Almansa Ruiz, Laura, Jiménez Sahagún, Rebeca, Primo Martín, David, Pedraza Hueso, María Isabel, Ramos Bachiller, Beatriz, González Gutiérrez, Jaime, Luis Román, Daniel Antonio de
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Universidad de Valladolid
Repository:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/68110
Online Access:https://doi.org/10.3390/nu16071021
https://uvadoc.uva.es/handle/10324/68110
Access Level:Open access
Keyword:Ultrasonography
Músculos
Ecografía
Amyotrophic lateral sclerosis
Esclerosis lateral amiotrófica
Malnutrition
Desnutrición
Neurology
Neuromuscular diseases
Enfermedades neuromusculares
Bioimpedanciometry
32 Ciencias Médicas
3206 Ciencias de la Nutrición
3205.07 Neurología
3207.11 Neuropatología
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oai_identifier_str oai:uvadoc.uva.es:10324/68110
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network_name_str España
repository_id_str
spelling Use of muscle ultrasonography in morphofunctional assessment of amyotrophic lateral sclerosis (ALS)López Gómez, Juan JoséIzaola Jauregui, OlatzAlmansa Ruiz, LauraJiménez Sahagún, RebecaPrimo Martín, DavidPedraza Hueso, María IsabelRamos Bachiller, BeatrizGonzález Gutiérrez, JaimeLuis Román, Daniel Antonio deUltrasonographyMúsculosEcografíaAmyotrophic lateral sclerosisEsclerosis lateral amiotróficaMalnutritionDesnutriciónNeurologyNeuromuscular diseasesEnfermedades neuromuscularesBioimpedanciometry32 Ciencias Médicas3206 Ciencias de la Nutrición3205.07 Neurología3207.11 NeuropatologíaProducción CientíficaAmyotrophic lateral sclerosis (ALS) is a progressive disease with a high prevalence of malnutrition that can influence prognosis. The main objective of this study is to compare the validity of muscle ultrasonography in the diagnosis of malnutrition and the prognosis of patients with ALS. Methods: This is a prospective observational study that analyzes the nutritional status of patients at the beginning of nutritional monitoring. The morphofunctional assessment included the examination of anthropometric variables such as weight, height, body mass index (BMI), arm circumference, and calf circumference. Additionally, electrical bioimpedanciometry (BIA) was used to measure electrical parameters and estimate other relevant metrics. Muscle ultrasonography® (quadriceps rectus femoris (QRF)) assessed muscle mass parameters, including muscle area index (MARAI), anteroposterior diameter of the QRF (Y-axis) (cm), transverse diameter of the QRF (X-axis) (cm), and the sum of the quadriceps thickness (RF+VI) (cm), as well as muscle quality parameters such as echogenicity and the Y–X index. Results: A total of 37 patients diagnosed with amyotrophic lateral sclerosis (ALS) were included in this study. Of these patients, 51.4% were men. The mean age was 64.27 (12.59) years. A total of 54.1% of the patients had a bulbar onset of amyotrophic lateral sclerosis, and 45.9% had spinal onset. The percentage of subjects with malnutrition diagnosed by the Global Leadership Initiative on Malnutrition (GLIM) criteria was 45.9% of patients. There was a direct correlation between muscle mass parameters assessed by muscle ultrasonography (RF+VI) and active mass markers measured by bioimpedanciometry (body cellular mass index (BCMI) (r = 0.62; p < 0.01), fat-free mass index (FFMI) (r = 0.75; p < 0.01), and appendicular skeletal mass index (ASMI) (r = 0.69; p < 0.01)). There was a direct correlation between echogenicity and resistance (r = 0.44; p = 0.02), as well as between the fat-free mass index and the Y–X index (r = 0.36; p = 0.14). Additionally, there was a negative correlation between echogenicity and BCMI (r = −0.46; p < 0.01) and ASMI (r = 0.34; p = 0.06). Patients with low quadriceps thickness (male < 2.49 cm; female < 1.84 cm) showed an increased risk of hospital admission adjusted by age, sex, and presence of dysphagia (OR: 7.84 (CI 95%: 1.09–56.07); p-value = 0.04), and patients with low-quality mass (Y–X index < 0.35) had a higher risk of hospital admission adjusted by age, sex, and presence of dysphagia (OR: 19.83 (CI 95%: 1.77–222.46); p-value = 0.02). Conclusions: In patients with ALS, ultrasonography echogenicity was inversely related to BCMI, FFMI, and ASMI, and the Y–X index was directly related to FFMI. The lowest quartiles of quadriceps thickness and Y–X index are risk factors for hospital admission.MDPI2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/nu16071021https://uvadoc.uva.es/handle/10324/68110reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/2072-6643/16/7/1021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/681102026-06-13T12:44:47Z
dc.title.none.fl_str_mv Use of muscle ultrasonography in morphofunctional assessment of amyotrophic lateral sclerosis (ALS)
title Use of muscle ultrasonography in morphofunctional assessment of amyotrophic lateral sclerosis (ALS)
spellingShingle Use of muscle ultrasonography in morphofunctional assessment of amyotrophic lateral sclerosis (ALS)
López Gómez, Juan José
Ultrasonography
Músculos
Ecografía
Amyotrophic lateral sclerosis
Esclerosis lateral amiotrófica
Malnutrition
Desnutrición
Neurology
Neuromuscular diseases
Enfermedades neuromusculares
Bioimpedanciometry
32 Ciencias Médicas
3206 Ciencias de la Nutrición
3205.07 Neurología
3207.11 Neuropatología
title_short Use of muscle ultrasonography in morphofunctional assessment of amyotrophic lateral sclerosis (ALS)
title_full Use of muscle ultrasonography in morphofunctional assessment of amyotrophic lateral sclerosis (ALS)
title_fullStr Use of muscle ultrasonography in morphofunctional assessment of amyotrophic lateral sclerosis (ALS)
title_full_unstemmed Use of muscle ultrasonography in morphofunctional assessment of amyotrophic lateral sclerosis (ALS)
title_sort Use of muscle ultrasonography in morphofunctional assessment of amyotrophic lateral sclerosis (ALS)
dc.creator.none.fl_str_mv López Gómez, Juan José
Izaola Jauregui, Olatz
Almansa Ruiz, Laura
Jiménez Sahagún, Rebeca
Primo Martín, David
Pedraza Hueso, María Isabel
Ramos Bachiller, Beatriz
González Gutiérrez, Jaime
Luis Román, Daniel Antonio de
author López Gómez, Juan José
author_facet López Gómez, Juan José
Izaola Jauregui, Olatz
Almansa Ruiz, Laura
Jiménez Sahagún, Rebeca
Primo Martín, David
Pedraza Hueso, María Isabel
Ramos Bachiller, Beatriz
González Gutiérrez, Jaime
Luis Román, Daniel Antonio de
author_role author
author2 Izaola Jauregui, Olatz
Almansa Ruiz, Laura
Jiménez Sahagún, Rebeca
Primo Martín, David
Pedraza Hueso, María Isabel
Ramos Bachiller, Beatriz
González Gutiérrez, Jaime
Luis Román, Daniel Antonio de
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ultrasonography
Músculos
Ecografía
Amyotrophic lateral sclerosis
Esclerosis lateral amiotrófica
Malnutrition
Desnutrición
Neurology
Neuromuscular diseases
Enfermedades neuromusculares
Bioimpedanciometry
32 Ciencias Médicas
3206 Ciencias de la Nutrición
3205.07 Neurología
3207.11 Neuropatología
topic Ultrasonography
Músculos
Ecografía
Amyotrophic lateral sclerosis
Esclerosis lateral amiotrófica
Malnutrition
Desnutrición
Neurology
Neuromuscular diseases
Enfermedades neuromusculares
Bioimpedanciometry
32 Ciencias Médicas
3206 Ciencias de la Nutrición
3205.07 Neurología
3207.11 Neuropatología
description Producción Científica
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/nu16071021
https://uvadoc.uva.es/handle/10324/68110
url https://doi.org/10.3390/nu16071021
https://uvadoc.uva.es/handle/10324/68110
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2072-6643/16/7/1021
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404333577076736
score 15,198674

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