High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residents

[EN]Angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) are two of the main components of the renin-angiotensin system (RAS). Imbalanced RAS showing lower ACE2 has been associated with increased cardiovascular risk, muscular pathologies, sarcopenia, frailty, other age-rela...

Descripción completa

Detalles Bibliográficos
Autores: Sanz Echevarría, María Begoña, Rezola Pardo, Chloe, Arrieta Etxeberria, Haritz, Fernández Atucha, Ainhoa, Lora Díaz, Inmaculada, Gil Goicouría, Francisco Javier, Rodríguez Larrad, Ana, Irazusta Astiazaran, Jon
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/54937
Acceso en línea:http://hdl.handle.net/10810/54937
Access Level:acceso abierto
Palabra clave:angiotensin-converting enzyme 2
biomarker
frailty
physical function
nursing home
id ES_1e55d867c2beaf8a2f01eba3d9405a14
oai_identifier_str oai:addi.ehu.eus:10810/54937
network_acronym_str ES
network_name_str España
repository_id_str
spelling High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residentsSanz Echevarría, María BegoñaRezola Pardo, ChloeArrieta Etxeberria, HaritzFernández Atucha, AinhoaLora Díaz, InmaculadaGil Goicouría, Francisco JavierRodríguez Larrad, AnaIrazusta Astiazaran, Jonangiotensin-converting enzyme 2biomarkerfrailtyphysical functionnursing home[EN]Angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) are two of the main components of the renin-angiotensin system (RAS). Imbalanced RAS showing lower ACE2 has been associated with increased cardiovascular risk, muscular pathologies, sarcopenia, frailty, other age-related pathologies and a poorer health status. However, its role in aging remains unclear. Thus, the aim of this work was to analyze the serum enzymatic activity of ACE and ACE2, the ACE/ACE2 ratio and its association with anthropometric parameters, blood pressure, physical function, dependence and frailty in older people living in nursing homes. This study is a secondary analysis of baseline data from two randomized clinical trials in a population of 228 older individuals living in nursing homes (Spain). Serum ACE and ACE2 enzymatic activities were measured by fluorimetry. Variables linked to cardiovascular risk, physical function, dependence and frailty were measured using validated tests, indexes and scales. Association between ACE, ACE2 serum activities, the ACE/ACE2 ratio and the rest of the quantitative variables were assessed by Pearson's correlations and by partial correlations controlled by age and sex. The association between serum ACE and ACE2 activities, the ACE/ACE2 ratio and frailty scores was analyzed by generalized linear models with and without controlling for sex and age. Differences in enzymatic activities between sexes and between frail and non-frail individuals were analyzed using Student's t-test and general linear models to control analysis by age and sex. We found that higher serum ACE2 activity was associated with a higher body mass index, worse physical function, greater dependence and increased frailty. This association is consistent with the elevation of circulating ACE2 in certain pathological conditions and in line with RAS deregulation in muscular dystrophies. Serum ACE2 activity, in combination with other molecules, could be proposed as a biomarker of poor physical function, higher dependence and frailty.This work was supported by grants from the Basque government (ELKARTEK19/78, SAN20/12) , and the University of the Basque Country (GIU17/19, GIU20/006) . Haritz Arrieta and Chloe Rezola were supported by two fellowships from the University of the Basque Country (UPV/EHU) . Open Access funding provided by University of Basque Country. The sponsors did not have a role in the design of the study, nor in the collection, analysis, and interpretation of data, nor in writing the manuscript.Elsevier202220222022info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/54937reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.sciencedirect.com/science/article/pii/S053155652100437X?via%3Dihubinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/3.0/es/© 2021 The Author(s). This is an open access article under the CC BY-NC-ND license.Atribución-NoComercial-SinDerivadas 3.0 Españaoai:addi.ehu.eus:10810/549372026-06-18T09:23:17Z
dc.title.none.fl_str_mv High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residents
title High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residents
spellingShingle High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residents
Sanz Echevarría, María Begoña
angiotensin-converting enzyme 2
biomarker
frailty
physical function
nursing home
title_short High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residents
title_full High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residents
title_fullStr High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residents
title_full_unstemmed High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residents
title_sort High serum angiotensin-converting enzyme 2 activity as a biomarker of frailty in nursing home residents
dc.creator.none.fl_str_mv Sanz Echevarría, María Begoña
Rezola Pardo, Chloe
Arrieta Etxeberria, Haritz
Fernández Atucha, Ainhoa
Lora Díaz, Inmaculada
Gil Goicouría, Francisco Javier
Rodríguez Larrad, Ana
Irazusta Astiazaran, Jon
author Sanz Echevarría, María Begoña
author_facet Sanz Echevarría, María Begoña
Rezola Pardo, Chloe
Arrieta Etxeberria, Haritz
Fernández Atucha, Ainhoa
Lora Díaz, Inmaculada
Gil Goicouría, Francisco Javier
Rodríguez Larrad, Ana
Irazusta Astiazaran, Jon
author_role author
author2 Rezola Pardo, Chloe
Arrieta Etxeberria, Haritz
Fernández Atucha, Ainhoa
Lora Díaz, Inmaculada
Gil Goicouría, Francisco Javier
Rodríguez Larrad, Ana
Irazusta Astiazaran, Jon
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv angiotensin-converting enzyme 2
biomarker
frailty
physical function
nursing home
topic angiotensin-converting enzyme 2
biomarker
frailty
physical function
nursing home
description [EN]Angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) are two of the main components of the renin-angiotensin system (RAS). Imbalanced RAS showing lower ACE2 has been associated with increased cardiovascular risk, muscular pathologies, sarcopenia, frailty, other age-related pathologies and a poorer health status. However, its role in aging remains unclear. Thus, the aim of this work was to analyze the serum enzymatic activity of ACE and ACE2, the ACE/ACE2 ratio and its association with anthropometric parameters, blood pressure, physical function, dependence and frailty in older people living in nursing homes. This study is a secondary analysis of baseline data from two randomized clinical trials in a population of 228 older individuals living in nursing homes (Spain). Serum ACE and ACE2 enzymatic activities were measured by fluorimetry. Variables linked to cardiovascular risk, physical function, dependence and frailty were measured using validated tests, indexes and scales. Association between ACE, ACE2 serum activities, the ACE/ACE2 ratio and the rest of the quantitative variables were assessed by Pearson's correlations and by partial correlations controlled by age and sex. The association between serum ACE and ACE2 activities, the ACE/ACE2 ratio and frailty scores was analyzed by generalized linear models with and without controlling for sex and age. Differences in enzymatic activities between sexes and between frail and non-frail individuals were analyzed using Student's t-test and general linear models to control analysis by age and sex. We found that higher serum ACE2 activity was associated with a higher body mass index, worse physical function, greater dependence and increased frailty. This association is consistent with the elevation of circulating ACE2 in certain pathological conditions and in line with RAS deregulation in muscular dystrophies. Serum ACE2 activity, in combination with other molecules, could be proposed as a biomarker of poor physical function, higher dependence and frailty.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/54937
url http://hdl.handle.net/10810/54937
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S053155652100437X?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
© 2021 The Author(s). This is an open access article under the CC BY-NC-ND license.
Atribución-NoComercial-SinDerivadas 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/3.0/es/
© 2021 The Author(s). This is an open access article under the CC BY-NC-ND license.
Atribución-NoComercial-SinDerivadas 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404330706075648
score 15,301629

Similares en LA Referencia