NMR studies of the interactions of glycan antigens with monoclonal antibodies.

123 p. Los capítulos: 2.3.2, 2.3.3, 2.3.4, 2.3.5, 2.4, 3.3.3, 3.3.4, 3.3.5, y 3.4 están sujetos a confidencialidad por la autora

Detalles Bibliográficos
Autor: Calloni, Ilaria
Tipo de recurso: tesis doctoral
Fecha de publicación:2020
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/49808
Acceso en línea:http://hdl.handle.net/10810/49808
Access Level:acceso abierto
Palabra clave:magnetic resonance spectroscopy
glucides
stereochemistry and conformational analysis
espectroscopia de resonancia magnética
glúcidos
estereoquímica y análisis conformacional
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spelling NMR studies of the interactions of glycan antigens with monoclonal antibodies.Calloni, Ilariamagnetic resonance spectroscopyglucidesstereochemistry and conformational analysisespectroscopia de resonancia magnéticaglúcidosestereoquímica y análisis conformacional123 p. Los capítulos: 2.3.2, 2.3.3, 2.3.4, 2.3.5, 2.4, 3.3.3, 3.3.4, 3.3.5, y 3.4 están sujetos a confidencialidad por la autoraCarbohydrates are one of the most variable and complex molecules of biological systems. They are usually located at the cell membrane, mainly as glycoconjugates, glycoproteins or glycolipids and play an important role in the specific molecular recognitions. Within glycans, polysaccharide capsules (CPS) are universal structures found on the cell surface of a broad range of bacterial species and often constitute the outermost layer of the cell; as such, they mediate the direct interactions between the bacterium and its immediate environment. Since structure and function are intrinsically correlated, the three-dimensional shape, dynamics and presentation of these molecules play a role in the recognition processes.In this work, we have employed a variety of Nuclear Magnetic Resonance spectroscopy (NMR) techniques, assisted by different computational approaches, in particular Molecular Dynamics (MD) simulation and ab initio methods, for obtaining atomic-scale information on the conformation, dynamics and interactions, in solution, of different types of capsular polysaccharides present in Neisseria meningitis and Streptococcus B.CICbioGUNESotomayor Anduiza, María NuriaReichardt, Niels ChristianJiménez Barbero, Jesús2021202120202020info:eu-repo/semantics/doctoralThesisapplication/pdfapplication/pdfhttp://hdl.handle.net/10810/49808reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/semantics/openAccess(c)2020 ILARIA CALLONIoai:addi.ehu.eus:10810/498082026-06-18T09:23:17Z
dc.title.none.fl_str_mv NMR studies of the interactions of glycan antigens with monoclonal antibodies.
title NMR studies of the interactions of glycan antigens with monoclonal antibodies.
spellingShingle NMR studies of the interactions of glycan antigens with monoclonal antibodies.
Calloni, Ilaria
magnetic resonance spectroscopy
glucides
stereochemistry and conformational analysis
espectroscopia de resonancia magnética
glúcidos
estereoquímica y análisis conformacional
title_short NMR studies of the interactions of glycan antigens with monoclonal antibodies.
title_full NMR studies of the interactions of glycan antigens with monoclonal antibodies.
title_fullStr NMR studies of the interactions of glycan antigens with monoclonal antibodies.
title_full_unstemmed NMR studies of the interactions of glycan antigens with monoclonal antibodies.
title_sort NMR studies of the interactions of glycan antigens with monoclonal antibodies.
dc.creator.none.fl_str_mv Calloni, Ilaria
author Calloni, Ilaria
author_facet Calloni, Ilaria
author_role author
dc.contributor.none.fl_str_mv Sotomayor Anduiza, María Nuria
Reichardt, Niels Christian
Jiménez Barbero, Jesús
dc.subject.none.fl_str_mv magnetic resonance spectroscopy
glucides
stereochemistry and conformational analysis
espectroscopia de resonancia magnética
glúcidos
estereoquímica y análisis conformacional
topic magnetic resonance spectroscopy
glucides
stereochemistry and conformational analysis
espectroscopia de resonancia magnética
glúcidos
estereoquímica y análisis conformacional
description 123 p. Los capítulos: 2.3.2, 2.3.3, 2.3.4, 2.3.5, 2.4, 3.3.3, 3.3.4, 3.3.5, y 3.4 están sujetos a confidencialidad por la autora
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/49808
url http://hdl.handle.net/10810/49808
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
(c)2020 ILARIA CALLONI
eu_rights_str_mv openAccess
rights_invalid_str_mv (c)2020 ILARIA CALLONI
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404330060152832
score 15,300724

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