Acute neuromuscular and perceptual responses to blood flow restriction exercise in adults with severe haemophilia: A pilot study

Introduction: No previous studies have implemented a standard blood flow restriction (BFR) training session in people with severe haemophilia (PwH), where this type of training has been contraindicated. Aims: The purpose of this study was to evaluate the tolerability, adverse events, and neuromuscul...

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Autores: Ogrezeanu, Daniel C., Calatayud, Joaquín, Rodríguez, Sergi, Carrasco, Juan J., Martinez-Valdes, Eduardo, Casaña, José, Cruz-Montecinos, Carlos, Andersen, Lars L., Aagaard, Per, López-Bueno, Rubén, Pérez-Alenda, Sofía
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Zaragoza
Repositorio:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:136401
Acceso en línea:http://zaguan.unizar.es/record/136401
Access Level:acceso abierto
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spelling Acute neuromuscular and perceptual responses to blood flow restriction exercise in adults with severe haemophilia: A pilot studyOgrezeanu, Daniel C.Calatayud, JoaquínRodríguez, SergiCarrasco, Juan J.Martinez-Valdes, EduardoCasaña, JoséCruz-Montecinos, CarlosAndersen, Lars L.Aagaard, PerLópez-Bueno, RubénPérez-Alenda, SofíaIntroduction: No previous studies have implemented a standard blood flow restriction (BFR) training session in people with severe haemophilia (PwH), where this type of training has been contraindicated. Aims: The purpose of this study was to evaluate the tolerability, adverse events, and neuromuscular and perceptual responses to an acute session of low load (LL) knee extensions with BFR in PwH under prophylaxis. Methods: Eight PwH performed one LL-BFR session with 40% arterial occlusion pressure (AOP). Perceptual responses and adverse effects were assessed, together with high-density surface electromyography of vastus medialis (VM) and lateralis (VL). Results: Significant normalized root mean square differences were found within each set, but not between sets. Spatial distribution (centroid displacement (p > .05), modified entropy (VM, set two, cycles three and five, p = .032) and coefficient of variation (VM, set two, cycles four and five lower than cycle three (p = .049; p = .036)) showed changes within each set. Median frequency showed a slight increase during cycle four of set four (p = .030). Rate of perceived exertion slightly increased with each set while tolerability slightly decreased in the last set and fear of training with BFR generally decreased after the session. Conclusions: In PwH, a LL-BFR session at 40% AOP is safe and feasible. Our results suggest that potential muscle impairments may blunt neuromuscular adaptations induced by BFR.2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://zaguan.unizar.es/record/136401reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1364012026-05-29T13:59:51Z
dc.title.none.fl_str_mv Acute neuromuscular and perceptual responses to blood flow restriction exercise in adults with severe haemophilia: A pilot study
title Acute neuromuscular and perceptual responses to blood flow restriction exercise in adults with severe haemophilia: A pilot study
spellingShingle Acute neuromuscular and perceptual responses to blood flow restriction exercise in adults with severe haemophilia: A pilot study
Ogrezeanu, Daniel C.
title_short Acute neuromuscular and perceptual responses to blood flow restriction exercise in adults with severe haemophilia: A pilot study
title_full Acute neuromuscular and perceptual responses to blood flow restriction exercise in adults with severe haemophilia: A pilot study
title_fullStr Acute neuromuscular and perceptual responses to blood flow restriction exercise in adults with severe haemophilia: A pilot study
title_full_unstemmed Acute neuromuscular and perceptual responses to blood flow restriction exercise in adults with severe haemophilia: A pilot study
title_sort Acute neuromuscular and perceptual responses to blood flow restriction exercise in adults with severe haemophilia: A pilot study
dc.creator.none.fl_str_mv Ogrezeanu, Daniel C.
Calatayud, Joaquín
Rodríguez, Sergi
Carrasco, Juan J.
Martinez-Valdes, Eduardo
Casaña, José
Cruz-Montecinos, Carlos
Andersen, Lars L.
Aagaard, Per
López-Bueno, Rubén
Pérez-Alenda, Sofía
author Ogrezeanu, Daniel C.
author_facet Ogrezeanu, Daniel C.
Calatayud, Joaquín
Rodríguez, Sergi
Carrasco, Juan J.
Martinez-Valdes, Eduardo
Casaña, José
Cruz-Montecinos, Carlos
Andersen, Lars L.
Aagaard, Per
López-Bueno, Rubén
Pérez-Alenda, Sofía
author_role author
author2 Calatayud, Joaquín
Rodríguez, Sergi
Carrasco, Juan J.
Martinez-Valdes, Eduardo
Casaña, José
Cruz-Montecinos, Carlos
Andersen, Lars L.
Aagaard, Per
López-Bueno, Rubén
Pérez-Alenda, Sofía
author2_role author
author
author
author
author
author
author
author
author
author
description Introduction: No previous studies have implemented a standard blood flow restriction (BFR) training session in people with severe haemophilia (PwH), where this type of training has been contraindicated. Aims: The purpose of this study was to evaluate the tolerability, adverse events, and neuromuscular and perceptual responses to an acute session of low load (LL) knee extensions with BFR in PwH under prophylaxis. Methods: Eight PwH performed one LL-BFR session with 40% arterial occlusion pressure (AOP). Perceptual responses and adverse effects were assessed, together with high-density surface electromyography of vastus medialis (VM) and lateralis (VL). Results: Significant normalized root mean square differences were found within each set, but not between sets. Spatial distribution (centroid displacement (p > .05), modified entropy (VM, set two, cycles three and five, p = .032) and coefficient of variation (VM, set two, cycles four and five lower than cycle three (p = .049; p = .036)) showed changes within each set. Median frequency showed a slight increase during cycle four of set four (p = .030). Rate of perceived exertion slightly increased with each set while tolerability slightly decreased in the last set and fear of training with BFR generally decreased after the session. Conclusions: In PwH, a LL-BFR session at 40% AOP is safe and feasible. Our results suggest that potential muscle impairments may blunt neuromuscular adaptations induced by BFR.
publishDate 2024
dc.date.none.fl_str_mv 2024
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dc.identifier.none.fl_str_mv http://zaguan.unizar.es/record/136401
url http://zaguan.unizar.es/record/136401
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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eu_rights_str_mv openAccess
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instname:Universidad de Zaragoza
instname_str Universidad de Zaragoza
reponame_str Zaguán. Repositorio Digital de la Universidad de Zaragoza
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