On the theory of cell migration: durotaxis and chemotaxis
This thesis presents a model of cell migration that integrates a description of force generation and cell deformation, adhesion site dynamics and RhoGTPases activation. The cell is modeled as a viscoelastic body capable of developing active traction and protrusion forces. The magnitude of stresses i...
| Autores: | , , |
|---|---|
| Tipo de recurso: | libro |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/26215 |
| Acceso en línea: | https://hdl.handle.net/2117/26215 |
| Access Level: | acceso abierto |
| Palabra clave: | Cell migration CIMNE Monograph Monografía CIMNE Cèl·lules -- Models matemàtics Àrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica Àrees temàtiques de la UPC::Ciències de la salut |
| Sumario: | This thesis presents a model of cell migration that integrates a description of force generation and cell deformation, adhesion site dynamics and RhoGTPases activation. The cell is modeled as a viscoelastic body capable of developing active traction and protrusion forces. The magnitude of stresses is determined by the activation level of the RhoGTPases, whose distribution in the cell body is described by a set of reaction-diffusion equations. Adhesion sites are modeled as punctual clusters of transmembrane receptors that dynamically bind and unbind the extracellular matrix depending on the force transmitted to them and the distance with ligands on the substrate. |
|---|