Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models

Candida auris is an emerging multidrug-resistant fungal pathogen responsible for nosocomial outbreaks of invasive candidiasis. Although several studies on the pathogenicity of this species have been reported, the knowledge on C. auris virulence is still limited. This study aims to analyze the pathog...

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Autores: Hernando Ortiz, Ainara, Mateo, Estibáliz, Pérez Rodríguez, Aitzol, de Groot, Petrus Wilhelmus Johannes, Quindós, Guillermo, Eraso, Elena
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/46920
Acceso en línea:https://www.tandfonline.com/doi/10.1080/21505594.2021.1908765
https://hdl.handle.net/10578/46920
Access Level:acceso abierto
Palabra clave:Candida auris
Candidiasis
Emerging pathogen
Invertebrate models
Virulence
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spelling Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host modelsHernando Ortiz, AinaraMateo, EstibálizPérez Rodríguez, Aitzolde Groot, Petrus Wilhelmus JohannesQuindós, GuillermoEraso, ElenaCandida aurisCandidiasisEmerging pathogenInvertebrate modelsVirulenceCandida auris is an emerging multidrug-resistant fungal pathogen responsible for nosocomial outbreaks of invasive candidiasis. Although several studies on the pathogenicity of this species have been reported, the knowledge on C. auris virulence is still limited. This study aims to analyze the pathogenicity of C. auris, using one aggregating isolate and eleven non-aggregating isolates from different clinical origins (blood, urine and oropharyngeal specimens) in two alternative host models of candidiasis: Caenorhabditis elegans and Galleria mellonella. Furthermore, possible associations between virulence, aggregation, biofilm-forming capacity, and clinical origin were assessed. The aggregating phenotype isolate was less virulent in both in vivo invertebrate infection models than non-aggregating isolates but showed higher capacity to form biofilms. Blood isolates were significantly more virulent than those isolated from urine and respiratory specimens in the G. mellonella model of candidiasis. We conclude that both models of candidiasis present pros and cons but prove useful to evaluate the virulence of C. auris in vivo. Both models also evidence the heterogeneity in virulence that this species can develop, which may be influenced by the aggregative phenotype and clinical originMDPI202620262021info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://www.tandfonline.com/doi/10.1080/21505594.2021.1908765https://hdl.handle.net/10578/46920reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésEuskal Herriko Unibertsitatea [PIF 16/39]Euskal Herriko Unibertsitatea [PIF17/167]Eusko Jaurlaritza [GIC15/78 IT-990-16]Ministerio de Economía y Competitividad [SAF2017-86188-P]info:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/469202026-05-27T07:36:41Z
dc.title.none.fl_str_mv Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models
title Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models
spellingShingle Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models
Hernando Ortiz, Ainara
Candida auris
Candidiasis
Emerging pathogen
Invertebrate models
Virulence
title_short Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models
title_full Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models
title_fullStr Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models
title_full_unstemmed Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models
title_sort Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models
dc.creator.none.fl_str_mv Hernando Ortiz, Ainara
Mateo, Estibáliz
Pérez Rodríguez, Aitzol
de Groot, Petrus Wilhelmus Johannes
Quindós, Guillermo
Eraso, Elena
author Hernando Ortiz, Ainara
author_facet Hernando Ortiz, Ainara
Mateo, Estibáliz
Pérez Rodríguez, Aitzol
de Groot, Petrus Wilhelmus Johannes
Quindós, Guillermo
Eraso, Elena
author_role author
author2 Mateo, Estibáliz
Pérez Rodríguez, Aitzol
de Groot, Petrus Wilhelmus Johannes
Quindós, Guillermo
Eraso, Elena
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Candida auris
Candidiasis
Emerging pathogen
Invertebrate models
Virulence
topic Candida auris
Candidiasis
Emerging pathogen
Invertebrate models
Virulence
description Candida auris is an emerging multidrug-resistant fungal pathogen responsible for nosocomial outbreaks of invasive candidiasis. Although several studies on the pathogenicity of this species have been reported, the knowledge on C. auris virulence is still limited. This study aims to analyze the pathogenicity of C. auris, using one aggregating isolate and eleven non-aggregating isolates from different clinical origins (blood, urine and oropharyngeal specimens) in two alternative host models of candidiasis: Caenorhabditis elegans and Galleria mellonella. Furthermore, possible associations between virulence, aggregation, biofilm-forming capacity, and clinical origin were assessed. The aggregating phenotype isolate was less virulent in both in vivo invertebrate infection models than non-aggregating isolates but showed higher capacity to form biofilms. Blood isolates were significantly more virulent than those isolated from urine and respiratory specimens in the G. mellonella model of candidiasis. We conclude that both models of candidiasis present pros and cons but prove useful to evaluate the virulence of C. auris in vivo. Both models also evidence the heterogeneity in virulence that this species can develop, which may be influenced by the aggregative phenotype and clinical origin
publishDate 2021
dc.date.none.fl_str_mv 2021
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://www.tandfonline.com/doi/10.1080/21505594.2021.1908765
https://hdl.handle.net/10578/46920
url https://www.tandfonline.com/doi/10.1080/21505594.2021.1908765
https://hdl.handle.net/10578/46920
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Euskal Herriko Unibertsitatea [PIF 16/39]
Euskal Herriko Unibertsitatea [PIF17/167]
Eusko Jaurlaritza [GIC15/78 IT-990-16]
Ministerio de Economía y Competitividad [SAF2017-86188-P]
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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