Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents

Magnetotactic bacteria are aquatic microorganisms that internally biomineralize chains of magnetic nanoparticles (called magnetosomes) and use them as a compass. Here it is shown that magnetotactic bacteria of the strain Magnetospirillum gryphiswaldense present high potential as magnetic hyperthermi...

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Autores: Gandia, David, Gandarias, Lucía, Rodrigo, Irati, Robles Garcia, Joshua, Das, Raja, Garaio, Eneko, García, José Ángel, Phan, Manh-Huong, Srikanth, Hariharan, Orue, Iñaki, Alonso Masa, Javier|||0000-0003-0045-5390, Muela, Alicia, Fernández Gubieda, María Luisa
Tipo de documento: artigo
Data de publicação:2019
País:España
Recursos:Universidad de Cantabria (UC)
Repositório:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglês
OAI Identifier:oai:repositorio.unican.es:10902/32825
Acesso em linha:https://hdl.handle.net/10902/32825
Access Level:Acceso aberto
Palavra-chave:Cancer therapy
Cytotoxicity
Internalization
Magnetic hyperthermia
Magnetotactic bacteria
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spelling Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agentsGandia, DavidGandarias, LucíaRodrigo, IratiRobles Garcia, JoshuaDas, RajaGaraio, EnekoGarcía, José ÁngelPhan, Manh-HuongSrikanth, HariharanOrue, IñakiAlonso Masa, Javier|||0000-0003-0045-5390Muela, AliciaFernández Gubieda, María LuisaCancer therapyCytotoxicityInternalizationMagnetic hyperthermiaMagnetotactic bacteriaMagnetotactic bacteria are aquatic microorganisms that internally biomineralize chains of magnetic nanoparticles (called magnetosomes) and use them as a compass. Here it is shown that magnetotactic bacteria of the strain Magnetospirillum gryphiswaldense present high potential as magnetic hyperthermia agents for cancer treatment. Their heating efficiency or specific absorption rate is determined using both calorimetric and AC magnetometry methods at different magnetic field amplitudes and frequencies. In addition, the effect of the alignment of the bacteria in the direction of the field during the hyperthermia experiments is also investigated. The experimental results demonstrate that the biological structure of the magnetosome chain of magnetotactic bacteria is perfect to enhance the hyperthermia efficiency. Furthermore, fluorescence and electron microscopy images show that these bacteria can be internalized by human lung carcinoma cells A549, and cytotoxicity studies reveal that they do not affect the viability or growth of the cancer cells. A preliminary in vitro hyperthermia study, working on clinical conditions, reveals that cancer cell proliferation is strongly affected by the hyperthermia treatment, making these bacteria promising candidates for biomedical applications.Spanish Government is acknowledged for funding under the project number MAT2017-83631-C3. USF coauthors acknowledge support from U.S. Department of Energy, Office of Basic Energy Sciences under Award No. DE-FG02- 07ER46438.Wiley-VCH VerlagUniversidad de Cantabria20192019-08-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/32825Small, 2019, 15, 1902626reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/328252026-06-02T12:39:31Z
dc.title.none.fl_str_mv Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents
title Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents
spellingShingle Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents
Gandia, David
Cancer therapy
Cytotoxicity
Internalization
Magnetic hyperthermia
Magnetotactic bacteria
title_short Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents
title_full Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents
title_fullStr Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents
title_full_unstemmed Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents
title_sort Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents
dc.creator.none.fl_str_mv Gandia, David
Gandarias, Lucía
Rodrigo, Irati
Robles Garcia, Joshua
Das, Raja
Garaio, Eneko
García, José Ángel
Phan, Manh-Huong
Srikanth, Hariharan
Orue, Iñaki
Alonso Masa, Javier|||0000-0003-0045-5390
Muela, Alicia
Fernández Gubieda, María Luisa
author Gandia, David
author_facet Gandia, David
Gandarias, Lucía
Rodrigo, Irati
Robles Garcia, Joshua
Das, Raja
Garaio, Eneko
García, José Ángel
Phan, Manh-Huong
Srikanth, Hariharan
Orue, Iñaki
Alonso Masa, Javier|||0000-0003-0045-5390
Muela, Alicia
Fernández Gubieda, María Luisa
author_role author
author2 Gandarias, Lucía
Rodrigo, Irati
Robles Garcia, Joshua
Das, Raja
Garaio, Eneko
García, José Ángel
Phan, Manh-Huong
Srikanth, Hariharan
Orue, Iñaki
Alonso Masa, Javier|||0000-0003-0045-5390
Muela, Alicia
Fernández Gubieda, María Luisa
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Cancer therapy
Cytotoxicity
Internalization
Magnetic hyperthermia
Magnetotactic bacteria
topic Cancer therapy
Cytotoxicity
Internalization
Magnetic hyperthermia
Magnetotactic bacteria
description Magnetotactic bacteria are aquatic microorganisms that internally biomineralize chains of magnetic nanoparticles (called magnetosomes) and use them as a compass. Here it is shown that magnetotactic bacteria of the strain Magnetospirillum gryphiswaldense present high potential as magnetic hyperthermia agents for cancer treatment. Their heating efficiency or specific absorption rate is determined using both calorimetric and AC magnetometry methods at different magnetic field amplitudes and frequencies. In addition, the effect of the alignment of the bacteria in the direction of the field during the hyperthermia experiments is also investigated. The experimental results demonstrate that the biological structure of the magnetosome chain of magnetotactic bacteria is perfect to enhance the hyperthermia efficiency. Furthermore, fluorescence and electron microscopy images show that these bacteria can be internalized by human lung carcinoma cells A549, and cytotoxicity studies reveal that they do not affect the viability or growth of the cancer cells. A preliminary in vitro hyperthermia study, working on clinical conditions, reveals that cancer cell proliferation is strongly affected by the hyperthermia treatment, making these bacteria promising candidates for biomedical applications.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-08-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/32825
url https://hdl.handle.net/10902/32825
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-VCH Verlag
publisher.none.fl_str_mv Wiley-VCH Verlag
dc.source.none.fl_str_mv Small, 2019, 15, 1902626
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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