SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis

Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant players in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo cocu...

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Detalles Bibliográficos
Autores: Sans de San Nicolàs, Lídia, Figueras Nart, Ignasi, Bonfill-Ortí, Montserrat, De Jesús-Gil, Carmen, García-Jiménez, Irene, Guilabert, Antonio, Curto-Barredo, Laia, Bertolín-Colilla, Marta, Ferran, Marta, Serra-Baldrich, Esther, Zalewska-Janowska, Anna, Wang, Yui-Hsi, Howell, Michael D., Pujol Vallverdú, Ramón M., Santamaria Babí, Luis F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/216418
Acceso en línea:https://hdl.handle.net/2445/216418
Access Level:acceso abierto
Palabra clave:Staphylococcus aureus
Dermatitis atòpica
Atopic dermatitis
Descripción
Sumario:Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant players in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circulating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to-severe AD patients.

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