Oestrogenicity of paper and cardboard extracts used as food containers

Bisphenol-A (BPA), dibutyl phthalate (DBP), and di-2-ethylhexyl phthalate (DEHP), which are common chemical residues in food-packaging materials, were investigated in paper and cardboard containers used for take-away food. The oestrogenicity of aqueous extracts was tested in E-Screen bioassay and an...

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Authors: Lopez-Espinosa, MJ, Granada, A, Araque, P, Molina-Molina, JM, Puertollano, MC, Rivas, A, Fernández, M, Cerrillo, I, Olea-Serrano, MF, López, C, Olea, N
Format: article
Status:Published version
Publication Date:2007
Country:España
Institution:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repository:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p16500
Online Access:https://fisabio.portalinvestigacion.com/publicaciones/16500
Access Level:Open access
Keyword:paper and cardboard
phthalates
bisphenol-A
oestrogenicity
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spelling Oestrogenicity of paper and cardboard extracts used as food containersLopez-Espinosa, MJGranada, AAraque, PMolina-Molina, JMPuertollano, MCRivas, AFernández, MCerrillo, IOlea-Serrano, MFLópez, COlea, Npaper and cardboardphthalatesbisphenol-AoestrogenicityBisphenol-A (BPA), dibutyl phthalate (DBP), and di-2-ethylhexyl phthalate (DEHP), which are common chemical residues in food-packaging materials, were investigated in paper and cardboard containers used for take-away food. The oestrogenicity of aqueous extracts was tested in E-Screen bioassay and analysis carried out by high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC/ MS). Oestrogenicity was demonstrated in 90% of extracts (geometric mean [GM] = 11.97 pM oestradiol equivalents g(-1)). DEHP, DBP, and BPA (GM = 341.74, 37.59, and 2.38 ng g(-1) of material) were present in 77.50, 67.50, and 47.50% of samples, respectively. In bivariate analyses, no significant association was found between the levels of these chemicals and oestrogenicity in cardboard/paper extracts. A close-to-significant association was found between oestrogenicity and DBP (beta = 1.25; p = 0.06) in paper extracts, which reached statistical significance in multivariate analysis (beta = 1.61; p = 0.03). Paper and cardboard used in food packaging may contribute to the inadvertent exposure of consumers to endocrine-disrupting chemicals.TAYLOR & FRANCIS LTD2007info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/16500Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk AssessmentISSN: 19440049ISSNe: 19440057reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p165002026-06-11T12:45:17Z
dc.title.none.fl_str_mv Oestrogenicity of paper and cardboard extracts used as food containers
title Oestrogenicity of paper and cardboard extracts used as food containers
spellingShingle Oestrogenicity of paper and cardboard extracts used as food containers
Lopez-Espinosa, MJ
paper and cardboard
phthalates
bisphenol-A
oestrogenicity
title_short Oestrogenicity of paper and cardboard extracts used as food containers
title_full Oestrogenicity of paper and cardboard extracts used as food containers
title_fullStr Oestrogenicity of paper and cardboard extracts used as food containers
title_full_unstemmed Oestrogenicity of paper and cardboard extracts used as food containers
title_sort Oestrogenicity of paper and cardboard extracts used as food containers
dc.creator.none.fl_str_mv Lopez-Espinosa, MJ
Granada, A
Araque, P
Molina-Molina, JM
Puertollano, MC
Rivas, A
Fernández, M
Cerrillo, I
Olea-Serrano, MF
López, C
Olea, N
author Lopez-Espinosa, MJ
author_facet Lopez-Espinosa, MJ
Granada, A
Araque, P
Molina-Molina, JM
Puertollano, MC
Rivas, A
Fernández, M
Cerrillo, I
Olea-Serrano, MF
López, C
Olea, N
author_role author
author2 Granada, A
Araque, P
Molina-Molina, JM
Puertollano, MC
Rivas, A
Fernández, M
Cerrillo, I
Olea-Serrano, MF
López, C
Olea, N
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv paper and cardboard
phthalates
bisphenol-A
oestrogenicity
topic paper and cardboard
phthalates
bisphenol-A
oestrogenicity
description Bisphenol-A (BPA), dibutyl phthalate (DBP), and di-2-ethylhexyl phthalate (DEHP), which are common chemical residues in food-packaging materials, were investigated in paper and cardboard containers used for take-away food. The oestrogenicity of aqueous extracts was tested in E-Screen bioassay and analysis carried out by high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC/ MS). Oestrogenicity was demonstrated in 90% of extracts (geometric mean [GM] = 11.97 pM oestradiol equivalents g(-1)). DEHP, DBP, and BPA (GM = 341.74, 37.59, and 2.38 ng g(-1) of material) were present in 77.50, 67.50, and 47.50% of samples, respectively. In bivariate analyses, no significant association was found between the levels of these chemicals and oestrogenicity in cardboard/paper extracts. A close-to-significant association was found between oestrogenicity and DBP (beta = 1.25; p = 0.06) in paper extracts, which reached statistical significance in multivariate analysis (beta = 1.61; p = 0.03). Paper and cardboard used in food packaging may contribute to the inadvertent exposure of consumers to endocrine-disrupting chemicals.
publishDate 2007
dc.date.none.fl_str_mv 2007
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/16500
url https://fisabio.portalinvestigacion.com/publicaciones/16500
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv TAYLOR & FRANCIS LTD
publisher.none.fl_str_mv TAYLOR & FRANCIS LTD
dc.source.none.fl_str_mv Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
ISSN: 19440049
ISSNe: 19440057
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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