Enhancing spatial memory and pattern separation: Long-term effects of stimulant treatment in individuals with ADHD

This study explores the under-researched domain of long-term stimulant treatment in children and adolescents diagnosed with attention deficit hyperactivity disorder (ADHD). The necessity for extended treatment duration, often accompanied by safety concerns and side effects leading to treatment disco...

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Detalhes bibliográficos
Autores: Lobato Camacho, Francisco José, López García, Juan Carlos, Vargas Romero, Juan Pedro
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/162230
Acesso em linha:https://hdl.handle.net/11441/162230
https://doi.org/10.1016/j.bbr.2024.115211
Access Level:acceso abierto
Palavra-chave:ADHD
cognition
memory
methylphenidate
visuo-spatial functioning
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spelling Enhancing spatial memory and pattern separation: Long-term effects of stimulant treatment in individuals with ADHDLobato Camacho, Francisco JoséLópez García, Juan CarlosVargas Romero, Juan PedroADHDcognitionmemorymethylphenidatevisuo-spatial functioningThis study explores the under-researched domain of long-term stimulant treatment in children and adolescents diagnosed with attention deficit hyperactivity disorder (ADHD). The necessity for extended treatment duration, often accompanied by safety concerns and side effects leading to treatment discontinuation, underscores the significance of this investigation. Concurrently, comparative studies have revealed adverse impacts on vulnerable regions within the hippocampal formation, accompanied by behavioral perturbations. We employed computerized tests and virtual reality to assess spatial memory, pattern separation, and object recognition memory in a cohort of children diagnosed with ADHD receiving stimulant treatment. We compared their performance to a group of neurotypical peers. Our findings indicate that the ADHD group exhibited a lower performance in spatial memory, pattern separation, and object recognition memory than ND group. Intriguingly, a positive relationship emerged between the duration of stimulant treatment and performance in these variables. Notably, this improvement was not immediate to MPH treatment but becomes significant after 24 months of treatment. In contrast to previous comparative investigations, our study did not reveal a detrimental impact on spatial navigation, object recognition memory, or pattern separation, despite the known interplay of these cognitive processes with the hippocampal formation. These results shed new light on the nuanced effects of stimulant treatment in ADHD, underscoring the need for a more comprehensive understanding of long-term treatment outcomes.Ministerio de Ciencia e Innovación PID2019-110739GB-I00/AEI/10.13039/501100011033ElsevierPsicología ExperimentalMinisterio de Ciencia e Innovación (MICIN). España2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11441/162230https://doi.org/10.1016/j.bbr.2024.115211reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésBehavioural Brain Research, 475, 115211.PID2019-110739GB-I00/AEI/10.13039/501100011033https://doi.org/10.1016/j.bbr.2024.115211info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1622302026-06-17T12:51:07Z
dc.title.none.fl_str_mv Enhancing spatial memory and pattern separation: Long-term effects of stimulant treatment in individuals with ADHD
title Enhancing spatial memory and pattern separation: Long-term effects of stimulant treatment in individuals with ADHD
spellingShingle Enhancing spatial memory and pattern separation: Long-term effects of stimulant treatment in individuals with ADHD
Lobato Camacho, Francisco José
ADHD
cognition
memory
methylphenidate
visuo-spatial functioning
title_short Enhancing spatial memory and pattern separation: Long-term effects of stimulant treatment in individuals with ADHD
title_full Enhancing spatial memory and pattern separation: Long-term effects of stimulant treatment in individuals with ADHD
title_fullStr Enhancing spatial memory and pattern separation: Long-term effects of stimulant treatment in individuals with ADHD
title_full_unstemmed Enhancing spatial memory and pattern separation: Long-term effects of stimulant treatment in individuals with ADHD
title_sort Enhancing spatial memory and pattern separation: Long-term effects of stimulant treatment in individuals with ADHD
dc.creator.none.fl_str_mv Lobato Camacho, Francisco José
López García, Juan Carlos
Vargas Romero, Juan Pedro
author Lobato Camacho, Francisco José
author_facet Lobato Camacho, Francisco José
López García, Juan Carlos
Vargas Romero, Juan Pedro
author_role author
author2 López García, Juan Carlos
Vargas Romero, Juan Pedro
author2_role author
author
dc.contributor.none.fl_str_mv Psicología Experimental
Ministerio de Ciencia e Innovación (MICIN). España
dc.subject.none.fl_str_mv ADHD
cognition
memory
methylphenidate
visuo-spatial functioning
topic ADHD
cognition
memory
methylphenidate
visuo-spatial functioning
description This study explores the under-researched domain of long-term stimulant treatment in children and adolescents diagnosed with attention deficit hyperactivity disorder (ADHD). The necessity for extended treatment duration, often accompanied by safety concerns and side effects leading to treatment discontinuation, underscores the significance of this investigation. Concurrently, comparative studies have revealed adverse impacts on vulnerable regions within the hippocampal formation, accompanied by behavioral perturbations. We employed computerized tests and virtual reality to assess spatial memory, pattern separation, and object recognition memory in a cohort of children diagnosed with ADHD receiving stimulant treatment. We compared their performance to a group of neurotypical peers. Our findings indicate that the ADHD group exhibited a lower performance in spatial memory, pattern separation, and object recognition memory than ND group. Intriguingly, a positive relationship emerged between the duration of stimulant treatment and performance in these variables. Notably, this improvement was not immediate to MPH treatment but becomes significant after 24 months of treatment. In contrast to previous comparative investigations, our study did not reveal a detrimental impact on spatial navigation, object recognition memory, or pattern separation, despite the known interplay of these cognitive processes with the hippocampal formation. These results shed new light on the nuanced effects of stimulant treatment in ADHD, underscoring the need for a more comprehensive understanding of long-term treatment outcomes.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/162230
https://doi.org/10.1016/j.bbr.2024.115211
url https://hdl.handle.net/11441/162230
https://doi.org/10.1016/j.bbr.2024.115211
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Behavioural Brain Research, 475, 115211.
PID2019-110739GB-I00/AEI/10.13039/501100011033
https://doi.org/10.1016/j.bbr.2024.115211
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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