Control of plastidial metabolism by the Clp protease complex

Plant metabolism is strongly dependent on plastids. Besides hosting the photosynthetic machinery, these endosymbiotic organelles synthesize starch, fatty acids, amino acids, nucleotides, tetrapyrroles, and isoprenoids. Virtually all enzymes involved in plastid-localized metabolic pathways are encode...

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Autores: Rodríguez Concepción, Manuel|||0000-0002-1280-2305, D'Andrea, Lucio, Pulido, Pablo|||0000-0001-9092-3674
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:205852
Acesso em linha:https://ddd.uab.cat/record/205852
https://dx.doi.org/urn:doi:10.1093/jxb/ery441
Access Level:acceso abierto
Palavra-chave:Carotenoid
Chaperone
Chlorophyll
Chloroplast
Clp protease
Chromoplasts
Isoprenoid
Proteostasis
Tetrapyrrole
Unfolded protein response
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spelling Control of plastidial metabolism by the Clp protease complexRodríguez Concepción, Manuel|||0000-0002-1280-2305D'Andrea, LucioPulido, Pablo|||0000-0001-9092-3674CarotenoidChaperoneChlorophyllChloroplastClp proteaseChromoplastsIsoprenoidProteostasisTetrapyrroleUnfolded protein responsePlant metabolism is strongly dependent on plastids. Besides hosting the photosynthetic machinery, these endosymbiotic organelles synthesize starch, fatty acids, amino acids, nucleotides, tetrapyrroles, and isoprenoids. Virtually all enzymes involved in plastid-localized metabolic pathways are encoded by the nuclear genome and imported into plastids. Once there, protein quality control systems ensure proper folding of the mature forms and remove irreversibly damaged proteins. The Clp protease is the main machinery for protein degradation in the plastid stroma. Recent work has unveiled an increasing number of client proteins of this proteolytic complex in plants. Notably, a substantial proportion of these substrates are required for normal chloroplast metabolism, including enzymes involved in the production of essential tetrapyrroles and isoprenoids such as chlorophylls and carotenoids. The Clp protease complex acts in coordination with nuclear-encoded plastidial chaperones for the control of both enzyme levels and proper folding (i.e. activity). This communication involves a retrograde signaling pathway, similarly to the unfolded protein response previously characterized in mitochondria and endoplasmic reticulum. Coordinated Clp protease and chaperone activities appear to further influence other plastid processes, such as the differentiation of chloroplasts into carotenoid-accumulating chromoplasts during fruit ripening. 22019-01-0120192019-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcAMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/205852https://dx.doi.org/urn:doi:10.1093/jxb/ery441reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 BIO2015-71703-REDTMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 BIO2017-90877-REDTAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 BIO2017-84041-PAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-710Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2015-0533open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2058522026-06-06T12:50:31Z
dc.title.none.fl_str_mv Control of plastidial metabolism by the Clp protease complex
title Control of plastidial metabolism by the Clp protease complex
spellingShingle Control of plastidial metabolism by the Clp protease complex
Rodríguez Concepción, Manuel|||0000-0002-1280-2305
Carotenoid
Chaperone
Chlorophyll
Chloroplast
Clp protease
Chromoplasts
Isoprenoid
Proteostasis
Tetrapyrrole
Unfolded protein response
title_short Control of plastidial metabolism by the Clp protease complex
title_full Control of plastidial metabolism by the Clp protease complex
title_fullStr Control of plastidial metabolism by the Clp protease complex
title_full_unstemmed Control of plastidial metabolism by the Clp protease complex
title_sort Control of plastidial metabolism by the Clp protease complex
dc.creator.none.fl_str_mv Rodríguez Concepción, Manuel|||0000-0002-1280-2305
D'Andrea, Lucio
Pulido, Pablo|||0000-0001-9092-3674
author Rodríguez Concepción, Manuel|||0000-0002-1280-2305
author_facet Rodríguez Concepción, Manuel|||0000-0002-1280-2305
D'Andrea, Lucio
Pulido, Pablo|||0000-0001-9092-3674
author_role author
author2 D'Andrea, Lucio
Pulido, Pablo|||0000-0001-9092-3674
author2_role author
author
dc.subject.none.fl_str_mv Carotenoid
Chaperone
Chlorophyll
Chloroplast
Clp protease
Chromoplasts
Isoprenoid
Proteostasis
Tetrapyrrole
Unfolded protein response
topic Carotenoid
Chaperone
Chlorophyll
Chloroplast
Clp protease
Chromoplasts
Isoprenoid
Proteostasis
Tetrapyrrole
Unfolded protein response
description Plant metabolism is strongly dependent on plastids. Besides hosting the photosynthetic machinery, these endosymbiotic organelles synthesize starch, fatty acids, amino acids, nucleotides, tetrapyrroles, and isoprenoids. Virtually all enzymes involved in plastid-localized metabolic pathways are encoded by the nuclear genome and imported into plastids. Once there, protein quality control systems ensure proper folding of the mature forms and remove irreversibly damaged proteins. The Clp protease is the main machinery for protein degradation in the plastid stroma. Recent work has unveiled an increasing number of client proteins of this proteolytic complex in plants. Notably, a substantial proportion of these substrates are required for normal chloroplast metabolism, including enzymes involved in the production of essential tetrapyrroles and isoprenoids such as chlorophylls and carotenoids. The Clp protease complex acts in coordination with nuclear-encoded plastidial chaperones for the control of both enzyme levels and proper folding (i.e. activity). This communication involves a retrograde signaling pathway, similarly to the unfolded protein response previously characterized in mitochondria and endoplasmic reticulum. Coordinated Clp protease and chaperone activities appear to further influence other plastid processes, such as the differentiation of chloroplasts into carotenoid-accumulating chromoplasts during fruit ripening.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/205852
https://dx.doi.org/urn:doi:10.1093/jxb/ery441
url https://ddd.uab.cat/record/205852
https://dx.doi.org/urn:doi:10.1093/jxb/ery441
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BIO2015-71703-REDT
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 BIO2017-90877-REDT
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 BIO2017-84041-P
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-710
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2015-0533
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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