Optimization of second‐generation lactic acid from corn stover by alkaline catalysis in subcritical water reaction medium

The optimization of hydrothermal lactic acid (LA) production from corn stover using Ca(OH)2 as catalyst was investigated. Initial studies with a 9 g L−1 glucose solution, and different Ca(OH)2 concentrations, in the range of 0.025–0.1 M, identified 0.075 M as the optimal concentration. Ca(OH)2 acted...

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Autores: Candela Gil, Helena, Illera Gigante, Alba Ester, Barea Gómez, Pedro, Ruiz Pérez, María Olga, Beltrán Calvo, Sagrario, Sanz Díez, Mª Teresa
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2025
País:España
Institución:Universidad de Burgos (UBU)
Repositorio:Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:oai:riubu.ubu.es:10259/10446
Acceso en línea:http://hdl.handle.net/10259/10446
Access Level:acceso abierto
Palabra clave:Alkaline catalysis
Subcritical water
Lactic acid
Corn stover
Molar ratio OH-/sugar monomers
Ingeniería Química
Biotecnología alimentaria
Bioquímica
Chemical engineering
Food-Biotechnology
Biochemistry
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spelling Optimization of second‐generation lactic acid from corn stover by alkaline catalysis in subcritical water reaction mediumCandela Gil, HelenaIllera Gigante, Alba EsterBarea Gómez, PedroRuiz Pérez, María OlgaBeltrán Calvo, SagrarioSanz Díez, Mª TeresaAlkaline catalysisSubcritical waterLactic acidCorn stoverMolar ratio OH-/sugar monomersIngeniería QuímicaBiotecnología alimentariaBioquímicaChemical engineeringFood-BiotechnologyBiochemistryThe optimization of hydrothermal lactic acid (LA) production from corn stover using Ca(OH)2 as catalyst was investigated. Initial studies with a 9 g L−1 glucose solution, and different Ca(OH)2 concentrations, in the range of 0.025–0.1 M, identified 0.075 M as the optimal concentration. Ca(OH)2 acted both as catalyst and reactant, neutralizing LA, and other organic acids produced, primarily acetic and formic acids. Excess Ca(OH)2 was required to maintain the alkaline environment necessary for LA production, achieving 3.5 g LA L−1 with a 40% yield. Lactic acid production from corn stover was studied at temperatures ranging from 90 to 260 °C with 0.075 M Ca(OH)2 and a biomass loading of 5 wt%. Higher temperatures increased LA production reaching 5.9 g LA L−1 with 15.1% of yield at 260 °C. The lower value of the yield compared with that obtained from glucose was attributed to the lower OH−/sugar monomer molar ratio, which was 3 for glucose, but only 0.65 for corn stover. To counteract organic acid formation, Ca(OH)2 concentrations up to 1.5 M were tested. The OH−/sugar monomer molar ratio emerged as a key design parameter, with an optimum value of 2.61, resulting in 12.4 g LA L−1 and 32% yield. This ratio compensates Ca(OH)2 consumption in neutralization reactions and minimizes excess base, which primarily remained in the solid residue owing to the low solubility of Ca(OH)2 in water. This approach also achieves minimal mass intensity, with 5.8 kg of reactants kg−1 of LA, with unnecessary reactant consumption.This work was supported by the Agencia Estatal de Investigación (grant numbers PID2022-136385OB-I00, TED2021-129311B-I00), the Junta de Castilla y León and the European Regional Development Fund (grant number BU027P23). A.E. Illera's postdoctoral contract was funded by BU027P23. H. Candela's pre-doctoral contract was funded by the Junta de Castilla y León and the European Social Fund (ORDEN EDU/1009/2024). P. Barea's pre-doctoral contract is funded by JCyL and the European Social Fund (ORDEN EDU/1868/2022).Open access funding provided by FEDER European Funds and the Junta De Castilla y León under the Research and Innovation Strategy for Smart Specialization (RIS3) of Castilla y León 2021-2027Wiley202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://hdl.handle.net/10259/10446reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)instname:Universidad de Burgos (UBU)InglésBiofuels, Bioproducts and Biorefining. 2025https://doi.org/10.1002/bbb.2785info:eu-repo/semantics/openAccessoai:riubu.ubu.es:10259/104462026-05-28T07:56:11Z
dc.title.none.fl_str_mv Optimization of second‐generation lactic acid from corn stover by alkaline catalysis in subcritical water reaction medium
title Optimization of second‐generation lactic acid from corn stover by alkaline catalysis in subcritical water reaction medium
spellingShingle Optimization of second‐generation lactic acid from corn stover by alkaline catalysis in subcritical water reaction medium
Candela Gil, Helena
Alkaline catalysis
Subcritical water
Lactic acid
Corn stover
Molar ratio OH-/sugar monomers
Ingeniería Química
Biotecnología alimentaria
Bioquímica
Chemical engineering
Food-Biotechnology
Biochemistry
title_short Optimization of second‐generation lactic acid from corn stover by alkaline catalysis in subcritical water reaction medium
title_full Optimization of second‐generation lactic acid from corn stover by alkaline catalysis in subcritical water reaction medium
title_fullStr Optimization of second‐generation lactic acid from corn stover by alkaline catalysis in subcritical water reaction medium
title_full_unstemmed Optimization of second‐generation lactic acid from corn stover by alkaline catalysis in subcritical water reaction medium
title_sort Optimization of second‐generation lactic acid from corn stover by alkaline catalysis in subcritical water reaction medium
dc.creator.none.fl_str_mv Candela Gil, Helena
Illera Gigante, Alba Ester
Barea Gómez, Pedro
Ruiz Pérez, María Olga
Beltrán Calvo, Sagrario
Sanz Díez, Mª Teresa
author Candela Gil, Helena
author_facet Candela Gil, Helena
Illera Gigante, Alba Ester
Barea Gómez, Pedro
Ruiz Pérez, María Olga
Beltrán Calvo, Sagrario
Sanz Díez, Mª Teresa
author_role author
author2 Illera Gigante, Alba Ester
Barea Gómez, Pedro
Ruiz Pérez, María Olga
Beltrán Calvo, Sagrario
Sanz Díez, Mª Teresa
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Alkaline catalysis
Subcritical water
Lactic acid
Corn stover
Molar ratio OH-/sugar monomers
Ingeniería Química
Biotecnología alimentaria
Bioquímica
Chemical engineering
Food-Biotechnology
Biochemistry
topic Alkaline catalysis
Subcritical water
Lactic acid
Corn stover
Molar ratio OH-/sugar monomers
Ingeniería Química
Biotecnología alimentaria
Bioquímica
Chemical engineering
Food-Biotechnology
Biochemistry
description The optimization of hydrothermal lactic acid (LA) production from corn stover using Ca(OH)2 as catalyst was investigated. Initial studies with a 9 g L−1 glucose solution, and different Ca(OH)2 concentrations, in the range of 0.025–0.1 M, identified 0.075 M as the optimal concentration. Ca(OH)2 acted both as catalyst and reactant, neutralizing LA, and other organic acids produced, primarily acetic and formic acids. Excess Ca(OH)2 was required to maintain the alkaline environment necessary for LA production, achieving 3.5 g LA L−1 with a 40% yield. Lactic acid production from corn stover was studied at temperatures ranging from 90 to 260 °C with 0.075 M Ca(OH)2 and a biomass loading of 5 wt%. Higher temperatures increased LA production reaching 5.9 g LA L−1 with 15.1% of yield at 260 °C. The lower value of the yield compared with that obtained from glucose was attributed to the lower OH−/sugar monomer molar ratio, which was 3 for glucose, but only 0.65 for corn stover. To counteract organic acid formation, Ca(OH)2 concentrations up to 1.5 M were tested. The OH−/sugar monomer molar ratio emerged as a key design parameter, with an optimum value of 2.61, resulting in 12.4 g LA L−1 and 32% yield. This ratio compensates Ca(OH)2 consumption in neutralization reactions and minimizes excess base, which primarily remained in the solid residue owing to the low solubility of Ca(OH)2 in water. This approach also achieves minimal mass intensity, with 5.8 kg of reactants kg−1 of LA, with unnecessary reactant consumption.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10259/10446
url http://hdl.handle.net/10259/10446
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biofuels, Bioproducts and Biorefining. 2025
https://doi.org/10.1002/bbb.2785
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)
instname:Universidad de Burgos (UBU)
instname_str Universidad de Burgos (UBU)
reponame_str Repositorio Institucional de la Universidad de Burgos (RIUBU)
collection Repositorio Institucional de la Universidad de Burgos (RIUBU)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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